Patenting the sun (6)

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Nova: RNAi 6/27/13

“Through a process known as RNAi (the “i” is for interference), researchers have a new way to shut off specific genes, yielding insights into the human genome as well as providing potential treatments for a wide range of diseases.”

That fact was patented as

1. RNA-Guided Human Genome Engineering
2. Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis
3. Methods for treating heartburn and/or preventing gastric bleeding or hemorrhage in patients receiving clopidogrel therapy

Taken together, the patents exemplify facts detailed in the context of MicroRNAs organize intrinsic variation into stem cell states 3/5/20 and in Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20

See also mirnas 158,942 results

If you are still alive on the morning of 6/13/23, see: Cancer Chemoresistance; Recent Challenges and Future Considerations 6/13/23

“….epigenetics, cell signaling, tumor heterogeneity, stem cells, microRNAs, endoplasmic reticulum, tumor microenvironment and exosomes have also been implicated in the multifaceted phenomenon of anticancer drug resistance.”

Given that fact, link Nutrient-dependent/pheromone-controlled adaptive evolution: a model 6/14/13 and Combating Evolution to fight disease 3/7/14 from the history of American Citizenship and Its Decline to the end of moronic theories.

For comparison: Molecular mechanisms that generate biological diversity are rewriting ideas about how evolution proceeds, with implications for treating disease.

For facts about light-activated miRNA-mediated molecular mechanisms linked to prevention or effective treatment of virus-driven diseases, see:

Dynamic growth QTL action in diverse light environments – characterization of light regime-specific and stable QTL in Arabidopsis 6/12/23

“…adjacent to the QTL interval, encodes a protein of unknown function that contains a putative RNA binding motif, is expressed in many plant tissues, and is putatively involved in many aspects of plant growth and development…”

“We concluded that this QTL is more likely to be underpinned by variation of gene expression levels, and not functional differences due to non-silent variation in the sequences of the two protein-encoding candidate genes.”

My summary: They use the ill-defined term “QTL” and facts about the yin yang symbol of energy balance to obfuscate facts that link light-activated changes in base pairs from SNPs to viral latency and healthy longevity via stem cell Creation and cell type differentiation. The facts are included in patents for naturally occurring RNA interference (#RNAi). The links from RNAi to supercoiled DNA were established by all intelligent serious scientists. But this group claims:

Their example of moronic gene-centric theories builds on misrepresentations of facts from:

MiR-107 Activates NF- κ B versus A β Analysis of the regulatory effect of 1-42 induced apoptosis in Alzheimer’s disease cells 3/31/23

“…miR-107 in primary neurons affects neurotransmitter factors in Alzheimer’s disease through the regulation of the NF-κB signaling pathway.”

Design of crRNA to Regulate MicroRNAs Related to Metastasis in Colorectal Cancer Using CRISPR-C2c2 (Cas13a) Technique 5/28/23

“The predicted interactions between crRNAs and Cas13a enzyme showed that crRNAs have a strong potential to inhibit metastasis. Therefore, crRNAs may be considered as an effective anticancer agent…”

Large Artificial microRNA Cluster Genes Confer Effective Resistance against Multiple Tomato Yellow Leaf Curl Viruses in Transgenic Tomato 5/31/23

(This article belongs to the Special Issue Effects of Small RNA on Plant-Pathogen Interactions)

The interactions are miRNA-mediated via RNA interference (RNAi) across kingdoms.

MicroRNA Regulation in Infectious Diseases and Its Potential as a Biosensor in Future Aquaculture Industry: A Review 5/26/23

(This article belongs to the Section Food Chemistry)

Influence of Estrus on Dairy Cow Milk Exosomal miRNAs and Their Role in Hormone Secretion by Granulosa Cells 6/1/23

(This article belongs to the Special Issue Characterization and Biological Function of Milk-Derived miRNAs)

Roles of Noncoding RNAs in Regulation of Mitochondrial Electron Transport Chain and Oxidative Phosphorylation

(This article belongs to the Special Issue Transport Mechanisms of Mitochondrial Membrane Proteins)

A toolbox for systematic discovery of stable and transient protein interactors in baker’s yeast 1/18/23

This article links the sexual differentiation of yeast cells to their pheromone-controlled physiology of reproduction without claims that cyanobacteria, also known as pond scum evolved into humans during billions to millions of years via natural selection for mutations.

For comparison see: Pervasive incomplete lineage sorting illuminates speciation and selection in primates 6/2/23

This comes from a Special Section in Science Magazine 6/2/23 that attests to the amount of human idiocy displayed by gene-centric theorists who seem to know nothing about RNA interference (RNAi), which was the 2002 Science Breakthrough of the year.

See: Breakthrough of the Year: Small RNAs

“…a string of recent discoveries indicates that a class of RNA molecules called small RNAs are actually in charge of many cellular functions. Science hails these discoveries, which are prompting biologists to overhaul their vision of the cell and its evolution, as 2002’s Breakthrough of the Year.”

Only by ignoring everything known to intelligent serious scientists about energy-dependent RNA interference can pseudoscientists continue to tout their moronic gene-centric theories.

Compare the facts about hydrogen bonding in From strong van der Waals complexes to hydrogen bonding: From CO⋯H2O to CS⋯H2O and SiO⋯H2O complexes 6/26/12 to the nonsense about The ancient history of kissing 5/18/23 and the history of claims made by Simon LeVay in Attraction, Love, Sex: The Inside Story 5/16/23

It is no wonder that this member of the John Birch society is fed up with the nonsense. See: The Origins & Evolution of LGBTQ Tyranny in America

“In this episode, Mr. Jasper joins TNA TV host Paul Dragu and TNA executive senior editor Steve Bonta to discuss the top-down forces that set in motion the depraved and tyrannical LGBTQ machine 100 years ago, the truth about the destructiveness of non-heterosexual lifestyles, and whether Western civilization can beat back this destructive force and reclaim its virtuous values.”  

Before you attack members of the John Birch for their history of hatred, see: Apology to People of Color for APA’s Role in Promoting, Perpetuating, and Failing to Challenge Racism, Racial Discrimination, and Human Hierarchy in U.S. 10/29/21; Is Homosexuality a Paraphilia? The Evidence For and Against 1/27/12 and Is pedophilia a sexual orientation? 12/22/13

Look at the history of pseudoscientific nonsense touted by social scientists and you will see that intelligent serious scientists have tried to prevent all virus-driven pathology.

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