Flipping off the flipons (10)

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“New Archeomagnetic Directional Records From Iron Age Southern Africa (ca. 425–1550 CE) and Implications for the South Atlantic Anomaly” 1/22/18 was reported as The ‘Big Flip’ Is Upon Us: Earth’s Magnetic Field is Dramatically Shifting Over Africa

“A million years is a long period, but in the big scheme of the Earth’s billions of years of geological history, these magnetic field reversals are very common.”

No experimental evidence of Top-down causation and quantum physics is linked by intelligent serious scientists to billions of years of geological history on Earth.

That may be why the video feed for MicroRNAs and Long Non-coding RNAs in Genetic Diseases 6/29/23 was hacked. (The webinar is reportedly being rescheduled.) Meanwhile, two of the scheduled presenters published additional indexed articles on PubMed that mention miRNAs in the context of stem cell Creation and cell type differentiation.

George A. Calin is the co-author of The long non-coding RNA NEAT1 is a ΔNp63 target gene modulating epidermal differentiation 6/26/23

“…these data uncover the lncRNA NEAT1 as an additional player of the intricate network orchestrating epidermal morphogenesis.”

Epidermal morphogeneis links mitochondrial energy-dependent construction of microRNA mediated cell wall construction across kingdoms via the transgenerational epigenetic inheritance of all morphological and behavioral phenotypes.

See also: Carlo M. Croce co-authored MicroRNA: trends in clinical trials of cancer diagnosis and therapy strategies 7/10/23

“Taewan Kim…and Carlo Croce…summarize the various ongoing and completed trials… The researchers discuss the development of drug mimics or inhibitors of specific microRNAs that are now in or nearing human testing as potential anti-cancer therapeutics. Although the research is still in its early stages, the authors envision a future where microRNA-based medicines and diagnostics become routine in cancer patient care…”

Claims that “…the research is still in its early stages…” can be viewed in the context of everything known about stem cell Creation and cell type differentiation across kingdoms in the context of 160,204 results from other articles that mention miRNAs and or the fact that The Transsulfuration Pathway makes Sulfate.

See: mirnas “Transsulfuration Pathway” mirnas “Transsulfuration Pathway”

Uremic Toxin Lanthionine Interferes with the Transsulfuration Pathway, Angiogenetic Signaling and Increases Intracellular Calcium

Abstract

(1) The beneficial effects of hydrogen sulfide (H₂S) on the cardiovascular and nervous system have recently been re-evaluated. It has been shown that lanthionine, a side product of H₂S biosynthesis, previously used as a marker for H₂S production, is dramatically increased in circulation in uremia, while H₂S release is impaired. Thus, lanthionine could be classified as a novel uremic toxin. Our research was aimed at defining the mechanism(s) for lanthionine toxicity. (2) The effect of lanthionine on H₂S release was tested by a novel lead acetate strip test (LAST) in EA.hy926 cell cultures. Effects of glutathione, as a redox agent, were assayed. Levels of sulfane sulfur were evaluated using the SSP4 probe and flow cytometry. Protein content and glutathionylation were analyzed by Western Blotting and immunoprecipitation, respectively. Gene expression and miRNA levels were assessed by qPCR. (3) We demonstrated that, in endothelial cells, lanthionine hampers H₂S release; reduces protein content and glutathionylation of transsulfuration enzyme cystathionine-β-synthase; modifies the expression of miR-200c and miR-423; lowers expression of vascular endothelial growth factor VEGF; increases Ca²⁺ levels. (4) Lanthionine-induced alterations in cell cultures, which involve both sulfur amino acid metabolism and calcium homeostasis, are consistent with uremic dysfunctional characteristics and further support the uremic toxin role of this amino acid.

See also: New-onset and relapsed thrombotic microangiopathy post-COVID-19 vaccination 7/12/23 The fact that one amino acid has been linked to uremic dysfunctional characteristics post COVID-19 vaccination attests to the problem theorists have with linking energy-as-information to biophysically constrained viral latency and healthy longevity via miRNA-mediated RNA interference (RNAi).

For facts about how constraint-breaking mutations are linked to all pathology at the level of hydrogen-atom transfer in DNA base pairs in solution, see: MTHFR Gene Mutation 7/11/23

“It is very confusing when they call this CBS variant A13637G which describes the position of the genetic error for this variant rs2851391 in the enzyme itself and then report T/T which is in reference to the error in the DNA “gene”.

This CBS variant rs2851391 will slow down the conversion of Homocysteine into Cystathionine that initiates the “Transsulfuration Pathway”. Therefore, there is little likelihood of “trouble” with sulfur in a person with a “SLOW” CBS variant. As a matter of fact, I would guess that if this were the only CBS variant the person had they would likely need to supplement with N-AcetylCysteine [NAC] and or Glutathione since one of the most important products of the “Transsulfuration Pathway” is the making of Glutathione which is the body’s most important antioxidant. If too little Homocysteine gets shunted down the “Transsulfuration Pathway” then less Glutathione would likely be made.

Glutathione is the body’s most important antioxidant.”

Having linked miRNA-mediated fixation of one energy-dependent amino acid substitution from a change in CBS variant rs2851391 to healthy longevity or to pathology via changes in glutathione, a review of the extant literature will allow you to link Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants 11/28/12 to the claims of Eric Lander in The discovery and potential of RNA interference 11/15/12

See also: Glutathione and miRNAs 700 results. Revisit: Conserved microRNAs and Flipons Shape Gene Expression during Development by Altering Promoter Conformations 3/3/23. Abandon your moronic theories before the next ‘Big Flip’ Is Upon Us. You may have a million years until that happens, but just in case see: Bacteria evolve over a weekend 2/26/15. It suggests that all neo-Darwinian theories and theories of Big Bang cosmology are wrong, and so does the fact that the theories have no explanatory power whatsoever.

See for comparison: Promise and perils of microRNA discovery research: Working towards quality over quantity 7/15/23

“…the miRNA field has boomed, with more than 100,000 related patents filed” and forthcoming results from a PubMed search for miRNAs that link the ATP-dependent Creation of RNA in regulatory T cells to all biodiversity on Earth via the physiology of energy-dependent reproduction and transgenerational epigenetic inheritance of viral latency.

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