Biogeochemical is geopolitical (2)

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next generation sequencing links differences in fixation of amino acid substitutions to healthy longevity. It also links mutations to all virus-driven diseases across kingdoms from microbes to humans. 7/29/23

The fixation of amino acid substitutions is energy-dependent. For comparison, see: Giant ‘bubbletrons’ shaped the forces of the universe moments after the Big Bang, new study suggests 7/30/23

“…massive bubbles may have emerged and collided with each other, powering up energies that would put to shame even our most advanced human-made particle accelerators, new research published June 27 on the preprint database arXiv suggests.”

Every attempt I’ve made to discuss the facts about energy-dependent miRNA-mediated fixation of amino acid substitutions and healthy longevity via RNA interference (RNAi) with pseudoscientists has been followed with one or more reports from bubble-brained theorists. Their moronic theories are not linked to any experimental evidence of top-down quantum causation and coherently organized biology across kingdoms. Attempts to discuss the facts fail when people who have no understanding of any aspect of experimentally-based cause and effect pretend to know something they don’t, or when they challenge the factual representations of intelligent serious scientists.

See for review: Richard Dawkins and long-time rival Denis Noble go head to head on the selfish gene | Who is right? 1/21/23 and Why biological sex matters 7/26/23

“Sex is a true binary. It all started with the evolution of anisogamy – sexual reproduction where the gametes are of two discontinuous sizes: macrogametes or eggs, and microgametes or sperm.”

No experimental evidence of top-down causation suggests that anisogamy “evolved or that transsexuals are anything more than confused.” See: Sex-specific assumptions and their importance in models of sexual selection 5/26/23

Experimental evidence of top-down causation links energy-as-information to sex differences in the cell types of yeasts to humans and to ethnic differences.

See for another bubble-brained theory: Large-Scale Explosions and Superbubbles in the Galactic Disk and Halo. I. Magnetohydrodynamic Simulations (1993)

For the five most recent additions to facts from 160,844 results on miRNA-mediated top-down causation, see:

MicroRNA Expression Levels in Peripheral Blood Mononuclear Cells from Human Immunodeficiency Virus Type 1 Positive Individuals and Relationship with Different Levels of Viral Suppression 7/31/23

“…uncontrolled viral replication leads to profound miRNA deregulation while treated individuals, irrespective of the degree of viral suppression, and even the types of antiviral drugs seem to be specifically associated with miRNA expression profiles. These evidences suggest that virological suppression could be favored by miRNA modulation.

Garlic-derived exosome-like nanovesicles alleviate dextran sulphate sodium-induced mouse colitis via the TLR4/MyD88/NF-κB pathway and gut microbiota modulation 7/31/23

“This study clarified the role of miRNAs of GENs in anti-colitis and proved that GENs had a potential application for IBD prevention.”

MicroRNA Cargo in Wharton’s Jelly MSC Small Extracellular Vesicles: Key Functionality to In Vitro Prevention and Treatment of Premature White Matter Injury 7/31/23

“Our in vitro study strongly indicates the key function of miRNAs in the therapeutic potential of WJ-MSC-sEV in premature WMI.”

Host-Delivered RNA Interference for Durable Pest Resistance in Plants: Advanced Methods, Challenges, and Applications 7/31/23

“Using artificial miRNA designs, the host-delivered RNAi + Bt combinatorial approach and chloroplast transformation can overcome limitations of RNAi.”

On the rules of engagement for microRNAs targeting protein coding regions 7/31/23

“…the consequences of CDS interactions may have been underestimated, with the reporting of a novel mode of miRNA-CDS interaction requiring base pairing of the miRNA 3′ end, but not the canonical seed site, leading to repression of translation with little effect on mRNA turnover.”

Energy-dependent changes in the miRNA-mRNA balance link illegal patents to claims by profiteers that were reported in Owning the Sun. The patents are based on gene-centric theories or other bubble-brained theories.

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