Biorealism (5)

By: James V. Kohl | Published on: November 23, 2023

5-Part Differential Cell Counter

“This type of hematology analyzer utilizes both Coulter’s Principle and flow cytometry to determine the granularity, diameter, and inner complexity of the cells. Using hydrodynamic focusing, the cells are sent through an aperture one cell at a time. During this, a laser is directed at them, and the scattered light is measured at multiple angles. The absorbance is also recorded. The cell can be identified based on the intensity of the scattered light and the level of absorbance.[8] A 5-part cell counter can differentiate all WBC types (neutrophils, lymphocytes, basophils, eosinophils, and monocytes)…”

While serving in the USAF from 1970 to 1977, I went for extra training to learn from the manufacturer how to operate and maintain a 5-part cell counter with a built in laser. Maintenance required the basic understanding of quantum coherence and coherently organized biology combined with occasional disassembly and reassembly of the the laser-based aperture, which was the central feature of a $250,000 instrument.

Measurements of blood gasses taught me how to link sunlight and humidity to all pH-dependent life on Earth via the differentiation of cell types across kingdoms, which were exemplified by the measurements from the laser hematology analyzer.

In the early 1980’s, I began to develop a model that detailed every aspect of Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18. George FR Ellis recapitulated my claims and added more facts in Top-down causation and quantum physics 10/22/18.

Next Generation Sequencing panels now provide examples of how energy-dependent changes in miRNAs are linked from stem cell Creation at the origin of life to all biodiversity via RNA-peptide interactions and measurements linked to hematopoietic stem cell Creation via the nutrient-dependent pheromone-regulated genetic processes of reproduction in species from microbes to humans.

See: Introduction to NGS

“Next-generation sequencing (NGS) is a massively parallel sequencing technology that offers ultra-high throughput, scalability, and speed. The technology is used to determine the order of nucleotides in entire genomes or targeted regions of DNA or RNA. NGS has revolutionized the biological sciences…”

See also: Detection of in vivo mutagenicity in rat liver samples using error-corrected sequencing techniques 11/22/23

It is no surprise that the C. elegans model organism exemplifies my claims in Nutrient-dependent/pheromone-controlled adaptive evolution: a model 6/14/13, which was a refutation of neo-Darwinian pseudoscientific nonsense about mutation-driven evolved biodiversity.

See: The neurobiological consequence of predating or grazing 1/17/13

“The patterns of synaptic connections perfectly mirror the fundamental differences in the feeding behaviours of P. pacificus and C. elegans”, Ralf Sommer concludes. A clear-cut result like that was not what he had necessarily expected. Previous studies in much simpler neural circuits – as in the marine snail Aplysia – had indicated that changes in behaviour do not have to coincide with changes in number and location of synapses. Differences in physiological properties of neurons or in their modulation by neurotransmitters can be sufficient to effect behavioural changes.”

The modulation of neurotransmitters has been linked to The neuropeptidergic connectome of C. elegans 11/15/23, which requires a link to the energy-dependent Creation of peptides at the origin of life.

Stress linked differentiation of blood cells carrying hemoglobin was linked to the ATP-dependent Creation of RNA in regulatory T cells and prevention of virus-driven pathology via fixation of amino acid substitutions that differentiate primate cell types in 1964.

See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

“The synthesis of RNA in isolated thymus nuclei is ATP dependent.”

See also: Biology, molecular and organismic

“Ingram and others found that hemoglobin S differs from A in the substitution of just a single amino acid, valine in place of glutamic acid in the beta chain of the hemoglobin molecule.”

Updated facts are included in:

The miR-221/222 cluster regulates hematopoietic stem cell quiescence and multipotency by suppressing both Fos/AP-1/IEG pathway activation and stress-like differentiation to granulocytes 11/20/23

For a historical perspective see: Regulation of genes in the arachidonic acid metabolic pathway by RNA processing and RNA-mediated mechanisms 8/16/13 Thank God if you lived long enough to link what was known in 2013 to the updated facts in Long noncoding RNAs and their complex role in shaping and regulating arachidonic acid metabolism: Learning to love the (not-really) junk 11/23/23

Ask yourself: “What kind of ignorant theorists link the claims in my life’s work From Fertilization to Adult Sexual Behavior (1996) to the pseudoscientific nonsense touted in Organizational Effects of Gonadal Hormones on Human Sexual Orientation 11/17/23 with no mention of my model or The structural and functional complexity of the integrative hypothalamus 10/26/23.”

David Puts is only one of them. Despite everything known to all intelligent serious scientists about RNA, the Epicenter of Genetic Information 9/22/23, Puts, and others like him, got trapped in a failed paradigm that has never been supported by experimental evidence from model organisms.

See Arousing Imaginations (2007)

“Isn’t there likely to be useful information about mates that is better obtained through vision and touch than through smell? If so, selection would probably favor more reliable developmental patterns for visual and tactile preferences than classical conditioning to olfactory ones.”

There is no experimental evidence to suggest that anything except classically conditioned responses to olfactory input is responsible for any aspect of RNA-mediated behavior in any species. Summary: Puts is a “putz” (a stupid or worthless person who engages in inconsequential or unproductive activity.)

See for comparison: Pheromone effects on the human hypothalamus in relation to sexual orientation and gender 7/17/21, Pheromonal Regulation of Genetic Processes: Research on the House Mouse (Mus musculus L.) (1994), and the patent for biophysically constrained stem cell Creation, viral latency, and healthy longevity acquired by Pfizer on 11/17/21: Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis

Notify of
Inline Feedbacks
View all comments

Want more on the same topic?

Swipe/Drag Left and Right To Browse Related Posts: