miRNA-mediated predictions (4)

By: James V. Kohl | Published on: December 27, 2023

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LncRNA-mir3471-limd1 regulatory network plays critical roles in HIBD 12/26/23

“…a protective role of miR-3471 during low oxygen stroke in HIBD [suggested]… involvement in the occurrence and development of HIBD, providing new insights for investigating the underlying mechanisms and exploring targeted therapeutic approaches for [oxygen-dependent prevention of hypoxic-ischemic brain damage] HIBD.

Historical perspective on brain-damaged children and adults:

Impact of MICA 3′UTR allelic variability on miRNA binding prediction, a bioinformatic approach 12/7/23

“MiRNAs can interfere with cellular processes by interacting with a broad spectrum of target genes under physiological and pathological states, including cancer development and progression. Major histocompatibility complex major histocompatibility complex class I-related chain A (MICA) belongs to a family of proteins that bind the natural-killer group 2, member D (NKG2D) receptor on Natural Killer cells and other cytotoxic lymphocytes.”

Food odors and pheromones regulate biophysically constrained MHC diversity in species from mice to humans, but the MHC changes to the human leukocyte antigens (HLA). The change confuses people who do not know that a single nucleotide polymorphism (SNP) in mice, EDAR 370A was linked to the biodiversity of morphology and behavior in Nutrient-dependent/pheromone-controlled adaptive evolution: a model 6/14/13 via citations to (Grossman et al., 2013; and to Kamberov et al., 2013).

“In the final degradation stage, acidic proteases acidify the lumen of the lysosomes and subsequently hydrolyze the autophagic lysosomes and their contents to remove out or reuse their hydrolyzed products such as amino acids, lipids, and nucleotides from the cells (Ravikumar et al., 2010) (Figure 1).”

This article is part of the Research Topic Cell fate and disease: The role of autophagy, apoptosis, ferroptosis, and necroptosis in human health and treatment

Like everything I have ever published, it is a neo-Darwinian theory killer and a Big Bang Cosmology theory killer.

“Mendelian genetics, classical genetics, Boveri–Sutton chromosome theory – first genetic theories…subsumed into molecular genetics.”

For comparison see Systems Biology 12/8/23, which includes the chapters System Biology Approach in Investigating Epithelial-Mesenchymal Transition (EMT) and Systems Biology Approaches to Understanding COVID-19 Spread in the Population 12/8/23

The superseded theories may also be viewed by ages 14+ in the context of Cellulose: A Plant Cell Biology Game “…a worker placement game that puts 1-5 players inside a plant cell, where they will compete over limited resources in order to undergo photosynthesis, produce carbohydrates, and build the cell wall to score points.”

Clearly, if you have not learned how energy-dependent cell wall construction is linked to all biodiversity on Earth via the physiology of reproduction at the origin of life, you are a loser. For instance, miRNA-mediated predictions predict that all theorists are losers. See our section on molecular epigenetics in From Fertilization to Adult Sexual Behavior (1996). The term pre-mRNA was subsequently changed to microRNA, miRNA, mir, and “…light-activated carbon fixation in cyanobacteria (pond scum) links fixation of amino acid substitutions in microtubules to pH-dependent healthy longevity across kingdoms via the physiology of reproduction, Biblical Genesis, and MAP proteins.