miRNA-mediated preditions (7)

By: James V. Kohl | Published on: January 1, 2024

Welcome to 2024, the year that all moronic theories will be eliminated by facts about God’s Creation of sunlight, humidity and oxygen-dependent life via the ATP-dependent miRNA-mediated differentiation of cell types across kingdoms. The facts are considered by intelligent serious scientists only in the context of the energy-dependent Creation of nucleic acids and miRNA-mediated ribonucleic acid (RNA) interference (RNAi).

Watch as moronic theorists are dragged kicking and screaming into the future of healthy longevity. See reports on next generation sequencing (NGS) and Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review 12/29/23

“Pertaining to the differential expression of miRNA attributed in target tissues and cellular bodies of innate and adaptive immunity, a paradigm of scientific expeditions suggests an optimistic correlation between immunogenic dysfunction and miRNA alterations.”

The paradigm shift links facts about next generation sequencing to virus-driven alterations in the degradation of mRNA to all pathology since the origin of life, which can be compared to biophysically constrained peptide synthesis and fixation of amino acid substitutions in the microtubules of all stem cells and all differentiated cell types in species from yeasts to humans via the ATP-dependent fine-tuning of protein folding chemistry.

For example: “Ingram and others found that hemoglobin S differs from A in the substitution of just a single amino acid, valine in place of glutamic acid in the beta chain of the hemoglobin molecule.” (Dobzhansky, 1964)

See also: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

“The synthesis of RNA in isolated thymus nuclei is ATP dependent.”

For an example that links the sexual differentiation of cell types in yeasts to humans, see: miRNA profiling of granulosa cell-derived exosomes reveals their role in promoting follicle development 12/27/23 with my emphasis.

MicroRNA (miRNA) profiles of exosomes from human GCs and follicular fluid were analyzed in depth. The signature was associated with folliculogenesis, such as phosphatidylinositol 3 kinases-protein kinase B signal pathway, mammalian target of rapamycin signal pathway, mitogen-activated protein kinase signal pathway, Wnt signal pathway, and cyclic adenosine monophosphate signal pathway. A total of five prominent miRNAs were found to regulate the above five signaling pathways. These miRNAs include miRNA-486-5p, miRNA-10b-5p, miRNA-100-5p, miRNA-99a-5p, and miRNA-21-5p. The exosomes from GCs and follicular fluid were investigated to explore the effect on folliculogenesis by injecting exosomes into older mice. The proportion of follicles at each stage is counted to help us understand folliculogenesis. Exosomes derived from GCs were isolated successfully. miRNA profiles demonstrated a remarkable overlap between the miRNA profiles of FF-Exos and GC-Exos. The shared miRNA signature exhibited a positive influence on follicle development and activation. Furthermore, exosomes derived from GCs and follicular fluid promoted folliculogenesis in older female mice. Exosomes derived from GCs had similar miRNA profiles and follicle-promoting functions as follicular fluid exosomes.

Patents for naturally occurring food energy-dependent pheromone-regulated genetic processes of luteinizing hormone (LH)-dependent reproduction are held by Harvard and by Pfizer, where gene-centric theorists may continue to promote their nonsense despite reports on

  1. Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20, and the link from
  2. Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections 4/23/20 to
  3. Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20, and
  4. The importance of naturally attenuated SARS-CoV-2 in the fight against COVID-19 4/28/20

For a historical perspective on naturally attenuated LH-dependent viral latency, see The Scent of Eros: Mysteries of Odor in Human Sexuality (1995/2002) and compare it to the pseudoscientific nonsense of neo-Darwinian theories in The Book of Animal Secrets 12/5/23.


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