Whistleblowers found: dead or alive (10)

By: James V. Kohl | Published on: March 21, 2024

microRNAs, oxidative stress, and genotoxicity as the main inducers in the pathobiology of cancer development” 3/21/24 (from researchers in Iran). It exemplifies 60 years of delayed scientific progress, unnecessary suffering, and premature deaths caused by moronic theorists with mathematical models that do not start with energy-dependent RNA synthesis in regulatory T cells.

For a historical perspective, see: “The synthesis of RNA in isolated thymus nuclei is ATP dependent [and miRNA-mediated]” (1964) Bruce McEwen was one of my mentors.

Moving forward, see: From molecular pathogenesis to therapy: Unraveling non-coding RNAs/DNMT3A axis in human cancers 3/2/24

I repeat: The authors from Iran and China link Next Generation Sequencing (NGS) panels to all energy-dependent biodiversity with details about the differences between mutations and fixation of amino acid substitutions in microtubules.

The differences are linked to effective therapies with Paxlovid and Paclitaxel via 20 copies of p53 and protein folding chemistry in African elephants via Insect Pheromones in Elephants Insect pheromone in elephants 2/22/96 and Vibrations in Microtubules (1997).

The almost immediate response to the most recent facts by moronic evolutionary theorists was: RNA-catalyzed evolution of catalytic RNA 3/4/24.

“Attempts to recreate RNA-based life in the laboratory must achieve further improvements in replication fidelity to enable the fully autonomous Darwinian evolution of RNA enzymes as complex as the polymerase itself.”

Translation: Theorists must start with energy-dependent creation of proteins called enzymes.

There was also a plea from Pfizer to strengthen the patents that stopped people from learning more about energy-dependent biophysically constrained viral latency.

See Harvard’s: RNA-Guided Human Genome Engineering and Pfizer’s Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis

See also: Utilizing non-coding RNA-mediated regulation of ATP binding cassette (ABC) transporters to overcome multidrug resistance to cancer chemotherapy 1/20/24

“Alternative mRNA polyadenylation intersects with microRNA-mediated transporter regulation.”

Translation: Alternative spilicings of pre-mRNA, now referred to as miRNAs in more that 169,536 indexed publications, links the ATP-/energy-dependent Creation of RNA in regulatory T cells to all biodiversity on Earth via RNA interference (RNAi), the 2002 Science Breakthrough of the Year.

For more details, see: Hong Kong takes lead in life sciences research

“Hong Kong has built a dynamic life sciences ecosystem, thanks to private sector innovation and government encouragement, and underpinned by a robust financial system. The city is also one of the world’s leading fundraising centres for biotech.”

Given all the facts known to intelligent serious scientists and detailed in my 2013 model, Michael A. Markosian, M.D @mikeama stated: Free will is not biophysically constrained. You need a new model.

His subsequent diatribes failed to link the energy-dependent creation of nucleic acids to our claims in From Fertilization to Adult Sexual Behavior (1996), and our claims in Human pheromones: integrating neuroendocrinology and ethology (2001) to my claims in Nutrient–dependent / pheromone–controlled adaptive evolution: a model (2013) and Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (2018) via everything known about energy-dependent microtubule inhibition and 20 copies of p53 in cancer-free African elephants.

Thus, the focus of intelligent serious scientists changed to the focus of a fool as he attempted to recover from his claim that I “need a new model.”

Theorists have no model, and their claims are not supported with examples from model organisms. See: How purposeless physics underlies purposeful life 10/4/23 “Perhaps the roundworm (Caenorhabditis elegans) could be used to explore this more…”


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