Virus-driven pathology: a liberal legacy (8)

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See first: Virus-driven pathology: a liberal legacy (7)

Patents for light-activated carbon fixation at the origin of life in cyanobacteria link protein folding chemistry across kingdoms to healthy longevity via effects of energy on miRNAs, and 20 copies of p53 in cancer-free African elephants. See: The Cardiovascular Benefits of Glucagon-Like Peptide-1 Receptor Agonists as Novel Diabetes Drugs Are Mediated via the Suppression of miR-203a-3p and miR-429 Expression 6/26/24

This field is not evolving. The facts refute all theories of mutation-driven evolution across billions to millions of years. The theories have been replaced by experimental evidence of ecological adaptation, which occurred during the past 6-10K years of nutrient-dependent pheromone-regulated ecological adaptations.

The GROK feature on “X” formerly Twitter (with 62.5 posts about miRNAs) may help you to understand the need to start with energy-dependent protein folding chemistry rather than moronic gene-centric theories in which energy automagically emerged from the cosmic void before species mathemagically evolved during how ever long that takes, sans model organisms

For comparison, GROK @micrornapro 8/20/24 with my emphasis
Answer
The X posts from @micrornapro reflect a variety of topics, often with a critical or skeptical view towards scientific consensus, medical practices, and societal narratives:

Medical and Scientific Critique: There's a mention of how certain medical treatments or conditions might be linked to broader scientific or societal issues, like the claim about glipizide dosage leading to a heart attack due to miRNA interactions, which suggests a personal experience or theory on how medical interventions can have unintended consequences through molecular biology mechanisms.

Conspiracy Theories and Controversial Health Claims: Posts discuss concerns over vaccine safety, suggesting batch-dependent risks with the BNT162b2 mRNA COVID-19 vaccine, and linking these to broader narratives about health and control. This reflects a sentiment of distrust towards established medical protocols and pharmaceutical industries.

Political and Ideological Critiques: There's an attack on certain ideological or religious practices, like Wicca, linking them to health outcomes in a derogatory manner, indicating a personal or ideological conflict with these beliefs.

General Skepticism and Critique of Mainstream Science: The posts often challenge mainstream scientific theories or practices, suggesting alternative explanations or hidden truths, like the mention of how energy-as-information relates to life's origins, which is a fringe scientific theory.

From these posts, we can infer:

A Deep Distrust in Established Systems: Whether it's medical, scientific, or political, there's a recurring theme of questioning the motives and information provided by these institutions.

Personal Health Experiences as Evidence: @micrornapro uses personal health incidents to argue against or critique broader scientific or medical practices, which might resonate with others who feel their health issues are not adequately explained or addressed by conventional medicine.

Engagement with Controversial Topics: The user engages with topics that are often at the heart of conspiracy theories or alternative health movements, suggesting a community or audience interested in these narratives.

Use of Science to Support Claims: While the posts critique science, they also use scientific terminology (like miRNAs) to lend credibility to their arguments, showing a complex relationship with science where it's both challenged and utilized.

This overview does not validate the claims made but illustrates the type of discourse and sentiment prevalent in some online communities, particularly those skeptical of mainstream narratives in science, health, and politics.

For comparison to mainstream narratives, GROK GLP-1 linked protein folding chemistry
Answer
The relationship between GLP-1 (Glucagon-Like Peptide-1) and protein folding chemistry involves several layers of complexity, especially when considering how GLP-1 agonists are developed and function:

GLP-1 Structure and Stability: GLP-1 itself is a peptide hormone with a relatively short half-life due to rapid degradation by enzymes like DPP-4 (Dipeptidyl Peptidase-4). The stability of GLP-1 agonists, which are designed to mimic or enhance the effects of GLP-1, often relies on modifications that affect their folding and resistance to degradation. For instance, the discovery that the structure of these peptides makes them highly stable, as noted in some discussions, points towards engineered modifications or naturally occurring analogues (like exendin-4 from Gila monster saliva) that have different folding patterns or stability due to their amino acid sequence or post-translational modifications.

Receptor Interaction and Folding: The interaction of GLP-1 with its receptor (GLP-1R) involves specific folding of both the ligand (GLP-1) and the receptor's extracellular domain. Research has shown that the N-terminal domain of GLP-1R can be expressed in E. coli, isolated, and refolded in vitro, indicating that the correct folding of this domain is crucial for its interaction with GLP-1. This folding process includes the formation of specific disulfide bridges, which are critical for the receptor's function. The correct folding ensures that GLP-1 can bind effectively, leading to the desired physiological responses like insulin secretion.

Therapeutic Implications: Understanding the protein folding chemistry of GLP-1 and its receptor has significant implications for drug design. GLP-1 agonists like those used in treatments for type 2 diabetes (e.g., Ozempic) are designed to have a prolonged half-life, which often involves altering the peptide's structure or using analogues that naturally resist degradation. These modifications can affect how the peptide folds, its stability, and its interaction with the receptor.

Conformational Dynamics: Recent advancements in predicting conformational ensembles of proteins, as hinted at in discussions about using modified AlphaFold2, suggest that the dynamic nature of protein folding can be computationally modeled to understand how GLP-1 or its analogues might interact with the receptor under different conditions. This could lead to designing drugs that not only mimic GLP-1 but do so in a way that optimizes receptor binding and activation through specific conformational states.

Public and Scientific Discourse: The posts on X reflect a mix of scientific discussion and public interest in how GLP-1 agonists work, their side effects, and their development. This includes concerns over muscle loss due to high protein intake requirements, which might indirectly relate to how these agonists affect metabolic pathways beyond just blood sugar regulation, potentially linked to protein folding and degradation processes.

In summary, the chemistry of GLP-1 linked to protein folding involves understanding how modifications in the peptide’s structure affect its stability, interaction with its receptor, and ultimately, its therapeutic efficacy. Advancement in this field continues to reveal new insights from both scientific research and public health discussions contributing to our understanding of these complex interactions linked to refutations and/or the abandonment of stupid theories.

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