Virus-driven pathology: a liberal legacy (10)

By: James V. Kohl | Published on: August 27, 2024

A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection 8/26/24 (Iran)

Benchmarking the negatives: Effect of negative data generation on the classification of miRNA-mRNA interactions 8/26/24 (Israel)

Ginkgetin induces cell death in breast cancer cells via downregulation of the estrogen receptor. 8/10/17 (Korea)

Ginkgo biloba derivative ginkgetin inhibits breast cancer growth by regulating the miRNA-122-5p/GALNT10 axis 8/26/24 (China)

Those who ridiculed Trump for his 4/23/20 claim that sunlight and humidity weaken coronaviruses can be blamed for the failure of intelligent serious scientists to convince people who will suffer unnecessarily and die prematurely from virus-driven diseases that they chose their outcome in the context of their overwhelming ignorance of cell biology. Researchers from Iran, Israel, and Korea represent the contingency of young earth Creationists with model organisms that attest to the claims of all intelligent physicists chemists and molecular biologists.

Elon Musk and Robert F. Kennedy Jr., have since joined forces with the former President of the USA in an attempt to bring Darwin’s (1859) claims about natural selection for “conditions of life” and healthy longevity back from children to adults via Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections 4/23/20; Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20; and The importance of naturally attenuated SARS-CoV-2in the fight against COVID-19 4/28/20

Many people are calling for the synthetic mRNA vaccine scam to end. See for example: Academic Corruption of Science. Until the corruption ends, see: Virus-driven pathology: a liberal legacy (9)

GROK @micrornapro 8/21/24

“General Skepticism and Critique of Mainstream Science: The posts often challenge mainstream scientific theories or practices, suggesting alternative explanations or hidden truths, like the mention of how energy-as-information relates to life’s origins, which is a fringe scientific theory.

Who benefits from maintaining nonsense about energy-as-information as if it were a fringe scientific theory linked to the origin of life?

See for comparison : GROK energy-as-information 8/22/24
Philosophical and Theoretical Insights: Some discussions, like those found on platforms like X, suggest that energy and information might be two sides of the same coin:

Energy as Information Regimes: Some theoretical discussions propose that energy might be understood through the lens of information regimes, where energy transformations are about changing states of information within systems.

In summary, while energy and information are distinct concepts, they’re deeply interconnected in both theoretical physics and practical applications. Energy can be viewed as a carrier or transformer of information, where processes involving energy often have implications for information, and vice versa, with energy being required to process, store, or erase information. This relationship is not just theoretical but has practical implications in fields like computing, thermodynamics, and even biological systems.

Practical implications can be viewed in the context of indexed publications that mention miRNAs: 175,116 results are linked to energy-dependent biological systems.

For instance: miRVim: Three-dimensional miRNA Structure Database 8/20/24

miRVim contains 13,971 predicted secondary structures and 17,045 predicted three-dimensional structures, filling the gap of unavailability of miRNA structure data bank. This database aims to facilitate computational data analysis for drug discovery, opening new avenues for advancing technologies, such as machine learning-based predictions in the field of RNA biology.

For facts about RNA biology compared to moronic DNA/gene-centric theories, see NOVA scienceNOW : 8 – RNAi YouTube·araniel·Jul 23, 2012

Stop letting theorists cause unnecessary suffering and/or kill the people you love. Learn about light-activated pH-dependent fixation of amino acid substitutions in microtubules via game play of Cellulose: A Plant Cell Biology Game for ages 14+ and more than 11K indexed publications that mention glp-1 receptor agonists.

For example: Long-term safety and efficacy of glucagon-like peptide-1 receptor agonists in individuals with obesity and without type 2 diabetes: A global retrospective cohort study 8/22/24

Our findings suggest that GLP-1 RAs may offer a comprehensive approach to managing obesity and its related comorbidities, potentially improving overall health and survival in this population.

Now that wealthy people can purchase GLP-1 RAs, it is likely that only the poor will be treated ineffectively. For example, on 9/24/24, I asked my primary care provider for a prescription of a GLP-1 RA and a consult to see a cardiologist. My dose of glipizide was doubled.

The consult was approved on 8/9/24, on 8/11/24, while still waiting to learn more about the consult, I had a glipizide-induced heart attack. I now have a stent. Thank God I was seen in a cardiologist’s office on on 8/23/24. However, I still have no hope of getting a prescription for a GLP-1 agonist. Neither do most of those with genetic variants linked to race. But I’m going to try to make that more fair.

Today, I submitted a complaint about this ‘medication issue’ to the Veterans Administration hotline. See also: Fair Allocation of GLP-1 and Dual GLP-1-GIP Receptor Agonists 8/22/24

The distribution framework for glucagon-like peptide-1 (GLP-1) receptor agonists proposed by Emanuel et al. in their Perspective article (May 30 issue)1 considers potential years of life lost (PYLL) from obesity-related disease, but not race. How can clinicians and policymakers implement this framework “irrespective of factors such as race” (Table 1 in the article) when race and ethnic group are strongly associated with both PYLL and the risk of obesity-related disease?




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