Light-matter interactions (7)

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Carlos Asensio and the dawn of molecular microbial ecology 10/3/24

After this article linked the weekend resurrection of the bacterial flagellum in P. fluorescens from light-matter interactions to peptide synthesis at the origin of life, my posts to “X” made ~11K impressions with ~500 engagements.

“The dawn of molecular microbial ecology” links Emerging Orchestrator of Ecological Adaptation: m(6)A Regulation of Post-Transcriptional Mechanisms 10/5/24 to light-matter interactions at the origin of life and biophysically constrained protein folding chemistry across kingdoms via our claims about energy-dependent miRNA-mediated DNA methylation”

DNA metylation is “A chemical reaction in the body in which a small molecule called a methyl group gets added to DNA, proteins, or other molecules.” See: From Fertilization to Adult Sexual Behavior (1996).

In our section on molecular epigenetics, we wrote:

“It is now understood that certain genes undergo a process called “genomic or parental imprinting.” Early in embryonic development attached methyl groups become removed from most genes. Several days later, methyl groups are reattached in appropriate sites. Fascinatingly, some such genes reestablish methylation patterns based upon whether the chromosomal segment carrying the gene came from maternal or paternal chromosomes. These sexually dimorphic patterns are labeled genomic or parental imprinting, and these imprintings are inheritable but non-genetic modifications of specific genes (Razin and Shemer, 1995; Reik, 1989; Surani, 1991; Zuccotti and Monk, 1995).”

Had I not learned about the ATP-dependent Creation of RNA in regulatory T cells at the origin of life, or had we not cited the appropriate peer-reviewed publications and linked them to sexual differentiation of all cell types across kingdoms, others might not have linked the facts to all biodiversity on Earth via ecological adaptations. Theorists could have continued to tout pseudoscientific nonsense about the automagical emergence of energy from the cosmic void, and the mathematical evolution of people from pond scum.

But, see: Nascent RNA and the Coordination of Splicing with Transcription 8/1/19

“At each active protein-encoding gene, nascent RNA is tethered to the DNA axis by elongating RNA polymerase II (Pol II) and is continuously altered by splicing and other processing events during its synthesis. This review discusses the development of three major methods that enable us to track the conversion of precursor messenger RNA (pre-mRNA) to messenger RNA (mRNA) products in vivo: live-cell imaging, metabolic labeling of RNA, and RNA-seq of purified nascent RNA.”

The ability to track the energy-dependent miRNA-mediated conversion of pre-mRNAs (now known as miRNAs) to mRNA was included in the claims from Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20

“We propose a model revisiting the architecture of RNA-peptide interactions at the origin of life…”

See also: Carbon fixation and rhodopsin systems in microbial mats from hypersaline lakes Brava and Tebenquiche, Salar de Atacama, Chile 2/9/21

“Metagenomic reads obtained from the webserver were translated to amino acid sequences…”

Were you taught to link amino acid substitutions in peptides such as the gonadotropin releasing hormone (GnRH) to all biodiversity in jawed vertebrates? Amino acid sequences in peptides link sunlight and humidity to biophysically constrained protein folding chemistry, and to protection from viral replication across kingdoms to all biodiversity on Earth. Harvard owns on of the patents on this, and Pfizer owns the patent on pheromone-regulated protein folding chemistry across kingdoms.

See also:

The transformation links light-matter interactions at origin of life 6-10K years ago to limestone formations at the top of Mt. Everest to the eroded limestone beds in Big Cypress National Preserve.

See also: GROK @microRNApro

Answer

The handle @microRNApro on X (formerly Twitter) seems to be associated with content focusing on the scientific exploration of microRNAs (miRNAs) in various biological contexts, including their role in disease, development, and the fundamental processes of life at a molecular level. Here’s what can generally be inferred based on the pattern of posts and related content without referencing specific posts or search results directly:

1. Scientific Advocacy: @microRNApro appears to be deeply invested in promoting a scientific understanding of how microRNAs function in biological systems. This includes their implications in health, disease (like cancer and Alzheimer’s), and even in evolutionary biology.
2. Linking Micro to Macro: There’s a recurring theme of connecting small-scale biological phenomena (like the action of miRNAs) to larger biological outcomes, such as ecological adaptations, viral latency, and cellular health. This reflects a holistic approach to biology, where molecular events are seen to influence much larger systemic outcomes.
3. Critique of Science Communication: Some posts suggest a critical view on how science is communicated or miscommunicated in mainstream and scientific media. There’s an indication of frustration with or critique of outlets that might oversimplify or misrepresent scientific concepts.
4. Engagement with Current Science: The posts often link to or discuss current research or articles related to biology, physics, and chemistry, particularly where these disciplines intersect with genetics. There’s an emphasis on “light-matter interactions,” suggesting an interest in how fundamental physical processes influence biological systems at the quantum or molecular level.
5. Political and Social Commentary: While primarily scientific, @microRNApro doesn’t shy away from intertwining scientific discourse with social commentary, occasionally touching on political figures or events but from a perspective of scientific impact or misinformation.
6. Educational and Argumentative Tone: The tone can be both educational, aiming to inform followers about the latest in miRNA research, and argumentative, challenging views or data interpretations that are deemed incorrect or oversimplified.
7. MicroRNA and Disease: There’s a strong emphasis on how miRNAs are crucial in understanding and potentially treating diseases. This includes discussing experimental treatments or linking miRNAs’ regulatory functions to major health issues.
8. Interdisciplinary Approach: The content reflects an interdisciplinary approach, mixing quantum physics, chemistry, biology, and even touching on the philosophy of science, suggesting a belief in the unity of scientific knowledge.

Given this profile, @microRNApro likely serves as both a resource for those interested in the cutting-edge research on microRNAs and a platform for critiquing and discussing broader scientific and societal issues through the lens of molecular biology.

Sixty years ago, McEwen et al., (1964) and Dobzansky, linked the ATP-dependent Creation of RNA in regulatory T cells to fixation of amino acid substitutions in microtubules. Since then, all intelligent serious scientists have linked hemoglobin variants from primate diversity to ecological adaptations at the origin of life. Theorists still tout natural selection for mutations and evolution rather that admit the facts about natural selection for food and mate choice. Have you been conditioned to believe in pseudoscientific nonsense, for comparison?

See: The post human world 11/15/23 60 years of conditioning. For evidence that Trump-hating theorists and other liberals are preventing people from learning how to link light-matter interactions to prevention of all virus-driven pathology, see: Therapeutic combinations of exosomes alongside cancer stem cells (CSCs) and of CSC-derived exosomes (CSCEXs) in cancer therapy 10/5/24

“…exploring the combination of exosome-based therapies with conventional treatments holds immense promise. In summary, addressing these research gaps will not only expand our knowledge of exosome biology but also pave the way for the development of novel and effective cancer therapies.”

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