Is the nucleotide conserved? (2)

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On 10/8/24, a friend asked me to explain the difference between a nucleic acid and an amino acid.

Amino acids are molecules that combine to form proteins.

Nucleic acids are large biomolecules that play essential roles in all cells and viruses.

Amino acids and proteins are the building blocks of life.

However, no experimental evidence suggests that life builds itself from nothing (which this comedian claims doesn’t exist).

For comparison: Nucleotides are existing organic molecules composed of a nitrogenous base, a pentose sugar and a phosphate. They serve as monomeric units of the nucleic acid polymers – deoxyribonucleic acid and ribonucleic acid, both of which are essential biomolecules within all life-forms on Earth.

For a historical perspective on God’s Creation of deoxyribonucleic acid (DNA), ribonucleic acid (RNA) and microRNAs (miRNA), see:

1. The Nobel Prize in Chemistry 2024 “for computational protein design” links the conservation of nucleotides to biophysically constrained viral latency via miRNA abundance in proteins.
2. MicroRNA-Triggered Programmable DNA-Encoded Pre-PROTACs for Cell-Selective and Controlled Protein Degradation 10/9/24, and 176,665 other results from today’s search for “miRNAs.”

1) “Proteins generally consist of 20 different amino acids, which can be described as life’s building blocks. In 2003, David Baker succeeded in using these blocks to design a new protein…”

2) “The integration of near-infrared light-mediated photodynamic therapy through an upconversion nanosystem further enhanced the efficacy of the platform with potent in vivo anticancer activity.”

1a) In 2020, Demis Hassabis and John Jumper presented an AI model called AlphaFold2. With its help, they have been able to predict the structure of virtually all the 200 million proteins that researchers have identified.

2a) I have elaborated on the model that links God’s ATP-dependent Creation of RNA at the origin of life from His Creation of regulatory T cells to every aspect of predictable biophysically constrained disease via protein folding chemistry and 20 copies of p53 in cancer-free African elephants. I typically advise others who do not understand protein folding chemistry to play Cellulose: A Plant Cell Biology Game for ages 14+.

If you can’t link the facts from microtubule inhibition and effective therapy for cancer, you are probably too far behind the experimental evidence published and/or presented during the past few decades and centuries. If you do not know how the energy-dependent conservation of nucleotides is linked to prevention of virus-driven pathology via fixation of amino acid substitutions in microtubules, you are probably a stupid theorist, or less than 14 years old.

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