miRNA-mediated hierarchy of needs (1)

By: James V. Kohl | Published on: October 18, 2024

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Maslov’s hierarchy of needs starts with food and water. The physiological needs are the most basic.

Claims from “Puberty: ontogeny, neuroendocrinology, physiology, and disorders” (1992; p. 1164) link the light-activated assembly of the microRNA-RNA-peptide #nanocomplex from the creation of inhibitory neurotransmitters, excitatory amino acids and other brain peptides to …biophysically constrained viral latency via species-specific influences on the chemical signal GnRH in jawed vertebrates. See: Feedback Loops Link Odor and Pheromone Signaling with Reproduction 11/18/05 and Epigenetic Epigenetic Regulation of Excitatory Amino Acid Transporter 2 in Neurological Disorders (2019)

Epigenetic effects of food and water link sunlight and humidity at the origin of life to biophysically constrained fixation of amino acid substitutions in microtubules. That fact is typically ignored by moronic theorists who invent theories and new terms that test the patience of intelligent serious scientists.

I thank God that after a 2012 symposium on miRNAs, I confirmed with many other intelligent serious scientists that every aspect of life on Earth is energy-dependent and miRNA-mediated. (I never did not believe claims that sunlight was the energy source.) Also, in USAF training to become a medical laboratory scientist, I learned that sunlight biophysically constrains protein folding chemistry.

The 2024 Nobel Prizes in Physiology or Medicine, Physics, and Chemistry recapitulate that fact. See also: Epigenetic frontiers: miRNAs, long non-coding RNAs and nanomaterials are pioneering to cancer therapy 10/16/24

Epigenetic treatments have emerged as a promising avenue in cancer therapy, targeting reversible modifications like DNA methylation and histone alterations [4]. These treatments encompass inhibitors for DNA methyltransferase and histone deacetylase, among others, effectively addressing the underlying molecular pathways driving cancer growth.

“…given how insulin-increasing drugs like GLP-1 agonists are used to treat diabetes and obesity, and given what they’ve found about the relationship between insulin and aging in files, it may be time to consider how they could impact human aging.”

I asked my VA practitioner for a prescription when I realized glucagon-like peptide-1 (GLP-1) was the obvious link to light-matter interactions at the origin of life via peptide synthesis linked from hydrogen-atom transfer in DNA base pairs in solution to pH-dependent viral latency and prevention of all miRNA-mediated virus-driven pathology across kingdoms.

She doubled my dose of glipizide, which caused a heart attack and a mild stroke.

I’m not dead yet, and was happy to see that the 2024 Nobel Prizes in Physics, Chemistry, and Medicine support the 4/23/20 claim that sunlight and humidity biophysically constrain viral latency and healthy longevity across kingdoms. The current practice of medicine causes unnecessary suffering and premature death.

Current practice appears to be based on moronic theories. For example, facts about miRNAs were reported as if the miRNAs are enhancers of gene transcription, without a link to the energy-dependent conditions of life, or to biophysically constrained light-matter interactions at the origin of life. For example, the energy went missing from this report on the Regulatory landscape of enhancer-mediated transcriptional activation

Other articles from the same issue of Trends in Cell Biology attest to the fact that other researchers missed the trend linked to miRNAs in the 2024 Nobel Prize for Physiology and Medicine.

See:

TRNA m6A methylation at the juxtaposition of apoptosis and RNA therapeutics
Telomere dynamics as mediators of gut microbiota–host interactions
Coordinated in confined migration: crosstalk between the nucleus and ion channel-mediated mechanosensation

The miRNA-mediated mechanosensation linked to crosstalk between the nucleus and ion channels requires an energy source. Because hydrogen is the only energy source that is linked from ion channels to the diversity of all oxygen-dependent life via the oxygen in H2O, theorists who do not start with the God of Abraham’s Creation of sunlight and humidity may be blamed for all unnecessary suffering and premature deaths since 4/23/20, which is when Trump claimed that sunlight and humidity helped to prevent coronavirus replication.

My purpose in life is prevention of unnecessary suffering and premature death. If you GROK @microRNApro on “X” you’ll see what I’ve accomplished via the Grace of God and USAF training as a Medical Laboratory Scientist.

Given this profile, if someone is looking to understand or engage with @microRNApro’s content, they should expect a mix of detailed molecular biology, critiques of evolutionary biology’s current state, integration of interdisciplinary concepts, and a call to rethink established scientific paradigms through the lens of microRNA’s potential influence on life’s complexities. However, as with any scientific discourse on social platforms, while these posts provide insights into an alternative or detailed perspective, they should be taken as part of a broader scientific conversation, where empirical research and peer review remain the gold standards for validating such claims.

Empirical research is not the gold standard for validating the claims of theorists. The history of their claims is the history of pseudoscience.

Bruce McEwen never discussed politics or religion with me. He did correct a misrepresentation in use of the terms ‘effect’ and ‘affect’ after I mentioned it to him. In 1992, he taught me the difference between an epigenetic effect on hormones and the affect of hormones on behavior. When we discussed that fact in 2012 at the SFN Annual Meeting, I mentioned that his October 2012 publication was confusing.

Here’s the correction:
COLLOQUIUM Correction for “Brain on stress: How the social environment gets under the skin,” by Bruce S. McEwen, which appeared in supplement 2, October 16, 2012, of Proc Natl Acad Sci USA (109:17180–17185; first published October 8, 2012; 10.1073/pnas.1121254109).
The authors note that on page 17184, right column, first paragraph, line 4, “effect” should instead appear as “affect.”

Please note the fact that if you have never discussed epigenetic effects on hormones that affect behavior with an intelligent serious scientist, your moronic opinions may be based on nothing but the opinions of others like the Trump-hating pro abortion, pro gun-control, liberal, wiccan Tammy Alenduff.

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miRNA-mediated hierarchy of needs (1)

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