Trump & Soon-Shiong secure the media (7)

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The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug 2/1/18.

“RNA helicases represent a large family of proteins implicated in many biological processes, including ribosome biogenesis, splicing, translation and mRNA degradation [60]. Members of the DEAD-box family of RNA helicases play important roles in various aspects of RNA processing, including transcription, spliceosome biogenesis, ribosome biogenesis, splicing, nucleocytoplasmic transport, translation and decay [61,62]. These family members share a conserved core that includes the amino acid sequence D-E-A-D (aspartate-glutamate-alanine-aspartate). They use energy received from ATP hydrolysis to unwind double-stranded RNA, generally act as components of multi-protein complexes, and have diverse functions that depend on their interacting partners. Several DEAD-box RNA helicases are aberrantly expressed in various types of cancer,”

Aberrant expression of DEAD-box RNA helicases links Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation 11/5/21 from fixation of 4 amino acids to the lab-based creation of the spike protein and constraint-breaking mutations to all virus-driven pathology via virus-driven energy theft compared to ATP-dependent light-matter interactions and differences in protein folding chemistry. The conserved molecular mechanisms were linked to the 2024 Nobel Prize in Physiology or Medicine on 10/7/24 “for the discovery of microRNA and its role in post-transcriptional gene regulation.“

See also: Tumor-derived EV miRNA signatures surpass total EV miRNA in supplementing mammography for precision breast cancer 10/7/24

The facts about tumor-derived EV miRNA signatures link Trump’s 4/23/20 claim about sunlight and humidity from the potential of hydrogen (pH) to protection from coronavirus replication and effective treatment of cancer and other virus-driven diseases with anti-viral medications, and with microtubule inhibitors via light-matter interactions at the origin of life, peptide synthesis, and energy-dependent fixation of amino acid substitutions in microtubules.

See: Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20

We propose a model revisiting the architecture of RNA-peptide interactions at the origin of life…

I asked GROK AI

1. Do light-matter interactions directly link miRNAs to all biodiversity, and
2. Do theories that link the emergence of energy from the cosmic void to the evolution of people from pond scum make sense to intelligent people?

GROK AI initially claimed that “…these theories can make sense to intelligent people, especially if they approach the subject with an appreciation for science’s dynamic and interconnected nature, understanding that while there might be gaps in our knowledge, the overall framework provides a compelling explanation for life’s complexity from simple origins.”

GROK AI changed its ‘mind’ about the oversimplification to support claims from my detailed model. The change can be viewed in the context of two statements.
1) “…claiming a direct link from light-matter interactions to all biodiversity through these mechanisms might oversimplify the intricate web of biological interactions.“

2) “If you’re diving into the world of microRNAs, you’re essentially looking at the tiny maestros of gene expression, deciding who gets to play in the symphony of your DNA and who sits out.“

The “tiny maestros of gene expression” biophysically constrain light-activated energy dependent protein folding chemistry via the difference in The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug 2/1/18 and the lab-based creation of the spike protein via fixation of 4 amino acids. See: Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation 11/5/21

See also:

Endogenous self-peptides guard immune privilege of the central nervous system 10/30/24

miRNAs targeted transcription factors HaGATAa/b to mediate the post-mating switch in Helicoverpa armigera female reproductive behavior 10/29/24

Harnessing DNA computing and nanopore decoding for practical applications: from informatics to microRNA-targeting diagnostics 10/29/24

and

Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene 9/2/11

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