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Aquaporins in sepsis- an update 10/31/24

This is one of the articles included in Molecular Mechanisms and Therapeutic Strategies in Inflammation 10/30/24

Re: “…increased glycolysis and changes in fatty acid and amino acid utilization, which occur during the proinflammatory phase of sepsis (104). Similar to tubular epithelial cells (TECs), immune cells in sepsis may undergo a profound metabolic transformation, transitioning from oxidative phosphorylation (OXPHOS) to a predominance of aerobic glycolysis. Within this metabolic realignment, the majority of pyruvate generated through glycolysis avoids mitochondrial entry and is instead converted into lactate—a process catalyzed by lactate dehydrogenase (LDH).

This strategic metabolic adaptation is crucial, as it supports increased ATP production through glycolysis to meet the elevated energy demands imposed by the septic challenge (105)…

Claims that link strategic metabolic adaptations to light-matter interactions and miRNA-mRNA interactions from protein-protein interactions to pH-dependent protection from the virus-driven degradation of mRNA and all pathology across kingdoms were placed into the context of the 2024 Nobel Prize in Physiology or Medicine for the discovery of microRNA and its role in post-transcriptional gene regulation. For instance, H2O links oxidative phosphorylation from aquaporins to cell wall construction, which protects cell types from the entry of viruses that links viral replication to all pathology across kingdoms.

Evolutionary theorists and Big Bang cosmologists were devastated to learn that energy did not automagically emerge from the cosmic void and mathemagically link the evolution of pond scum to people during billions to millions of years. When Ontangelo Grasso was faced with the facts about ecological adaptations, he published this undated treatise: “Why Genomes Alone Can’t Decode Cell Types: An
Integrated Systems Perspective” (link opens pdf)

Clearly he knows that no experimental evidence suggests the ecological adaptations occurred during more than 6-10,000 years since the origin of life. Only gene-centric theorists attest to the nonsense of Intelligent Design.

In the early 1990’s, Bruce S. McEwen presciently taught me to not start with gene-centric theories. His advice led me to detail how epigenetic effects link energy-dependent gene activation in achiral glycine in position 6 of the GnRH decapeptide to protection from nutrient-stress and social-stress.

Energy-dependent gene activation was subsequently linked to all biodiversity via biophysically constrained miRNA-mediated viral latency in the context of differences in effects on hormones linked to differences in the affects of hormones on behavior.

See: “Brain on stress: How the social environment gets under the skin” (2012). After we spoke about this during SFN (2012), he published a correction on differences between effect and affect. See: Correction for McEwen, Brain on stress: How the social environment gets under the skin (2013).

The authors note that on page 17184, right column, first paragraph, line 4, “effect” should instead appear as “affect.”

Moronic theorists still have not corrected any aspect of the nonsense they link from angstroms to ecosystems across kingdoms without starting with the metabolism of food energy to pheromones in reports like this one: Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations 11/14/24 and/or reports of the ATP-dependent Creation of RNA and Role of circular RNAs in DNA repair 11/17/24

“…circRNAs were found to play a crucial role in DNA repair processes by regulating the expression and activity of proteins involved in various DNA repair pathways. They influence the expression of DNA repair proteins by interacting with their mRNAs, sponging miRNAs that target these mRNAs, regulating transcription factors that bind to their promoters, modulating upstream signalling pathways, and affecting mRNA translation.”

See for comparison: Algorithmic Focus:

• Google AI: Might focus on retrieving and summarizing information from authoritative sources, aiming for accuracy and relevance in scientific inquiries.
• Grok AI: Could be designed to provide conversational, sometimes humorous or opinionated responses, which might not prioritize scientific accuracy over entertainment or engagement. Its approach might be more about generating plausible answers based on patterns in its training data rather than strictly adhering to factual scientific literature.

Most of the intelligent people I know arrived the conclusion that Elon Musk is a player in the game of controversial claims, and that Grok AI is not a source for opinionated humor.

It is a source for obfuscation of the fact that sunlight, humidity and miRNA abundance at the origin of life were linked to constraints on all virus-driven pathology and healthy longevity across kingdoms when Trump claimed that sunlight and humidity prevented coronavirus replication on 4/23/20.

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