AI forgets what is known (1)

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In my model of “Energy as information and constrained endogenous RNA interference“, “Genes We Share With Yeast, Flies, Worms and Mice: New Clues to Human Health and Disease” 1/1/03 and “The Catalyst: RNA and the Quest to Unlock Life’s Deepest Secrets” 6/4/24 link the ATP-dependent Creation of RNA at the origin of life to all biodiversity on Earth via the physiology of reproduction, fixation of amino acid substitutions in microtubules, my group’s claims in our section on molecular epigenetics in From Fertilization to Adult Sexual Behavior (1996), and Vibrations in Microtubules (1997).

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AI Overview

“Energy as information and RNA interference” in the context of James Kohl’s work refers to the concept that energy can be interpreted as information within a biological system, specifically through the mechanism of RNA interference (RNAi), where changes in energy levels can influence gene expression by altering the activity of small RNA molecules within the cell. 

Key points about this concept:

• RNAi as a regulatory mechanism: RNAi is a natural process where cells use small RNA molecules to silence specific genes by preventing their mRNA from being translated into proteins. 

Energy impacting RNAi:

Kohl proposes that fluctuations in energy levels within a cell can affect the production, stability, or activity of these small RNA molecules, thereby influencing gene expression. 

Implications for cellular function:

This idea suggests that energy dynamics could play a significant role in regulating various cellular processes by controlling which genes are expressed and at what levels. 

See for comparison the nonsense touted by James Tour in his claims about what scientists don’t know.

Moving forward, see more about what is known to all intelligent serious scientists: Control of poly(A)-tail length and translation in vertebrate oocytes and early embryos 4/22/24

All four steps, which are linked to RNA interference (RNAi) and viral latency across kingdoms, are energy-dependent and miRNA-mediated. See the 2024 Nobel Prize in Physiology or Medicine “for the discovery of microRNA and its role in post-transcriptional gene regulation.” Stop the nonsense touted by James Tour and his idiot minions.

Tom Cech is equally offensive in: RNA Takes Center Stage 6/5/24

See for comparison: The guide-RNA sequence dictates the slicing kinetics and conformational dynamics of the Argonaute silencing complex 7/17/24

Exploring the dynamics of messenger ribonucleoprotein-mediated translation repression 11/27/24

Enzyme-Assisted Electrochemical Point-of-Care Test for miRNA Detection in Liquid Biopsy 11/27/24

Dual RNA-seq study of the dynamics of coding and non-coding RNA expression during Clostridioides difficile infection in a mouse model 11/27/24

For a historical perspective on microRNAs, hormones and behavior, see: Intertwined regulators: hypoxia pathway proteins, microRNAs, and phosphodiesterases in the control of steroidogenesis 2/15/24

and Blood-based microRNAs as the potential biomarkers for Alzheimer’s disease: evidence from a systematic review 11/28/24

People, like James Tour, who focus on what we don’t know seem to have forgotten what we do know. Alternatively, they may not want you to know what they failed to learn from model organisms about energy-dependent miRNA-mediated biophysically constrained viral latency.

See: Biochemical principles of miRNA targeting in flies 11/16/24

Automated services summary:

Research on microRNAs, crucial for gene regulation, has progressed significantly in mammals but remains less understood in fruit flies. This paper investigates how certain microRNAs in Drosophila target messenger RNAs, employing a method called RNA Bind-n-Seq to identify binding sites for four fly microRNAs. Results indicate that fruit fly microRNAs exhibit a narrower binding site diversity than their mammalian counterparts, primarily favoring canonical seed-matched sites with minimal tolerance for mismatches. Additionally, non-canonical binding sites were found to have comparable affinities to canonical ones. These insights enhance our understanding of microRNA-mediated regulation in fruit flies and lay groundwork for future predictive models in this area.

My summary: “Biochemical principles of miRNA targeting in flies” 11/16/24 links the 1910 claims of TH Morgan from “Insect pheromone in elephants” 2/22/96 to all biodiversity on Earth via the 2024 Nobel Prize in Medicine “for the discovery of microRNA and its role in post-transcriptional gene regulation.”

See also: Unveiling epigenetic regulatory elements associated with breast cancer development 11/15/24

Automated services summary
Breast cancer remains the most prevalent cancer among women, with new research shedding light on its complex genetic mechanisms. This study aimed to identify epigenetic changes linked to breast cancer progression by analyzing data from over 800 tumor samples. Using advanced computational techniques, the researchers pinpointed 2,701 significant features including mRNA levels and DNA methylation patterns that can distinguish cancerous from normal tissues. Their findings indicated that cancer cells often exhibit reduced gene expression, alongside increased DNA methylation at critical sites, which deregulated gene activity. This research underlines the importance of epigenetic factors in breast cancer development and may pave the way for new biomarkers and therapeutic targets.

My summary: The virus-driven degradation of mRNA links loosely packed chromatin in cancer to its prevention via 20 copies of p53 in cancer-free African elephants via the 2024 Nobel Prize in Medicine, and everything I learned about “…the discovery of microRNA and its role in post-transcriptional gene regulation.”

Prosecution of Trump-hating liberals, atheists, censors, and moronic theorists will begin soon after his inauguration. Meta’s Mark Zuckerberg already met with Trump in this regard. Patrick Soon-Shiong, who patented the effective treatment for cancer, is becoming more annoyed by the ignorance of senior media reporters, like Oliver Darcy.

For an exercise in the futility of attempts to link facts to the elimination of pseudoscientific nonsense, see Why is no Nobel Prize awarded for works linked to theories used to support the claims of psychologists? and 178,387 results from today’s PubMed search for “miRNAs.”

Never forget, the most recent addition is Blood-based microRNAs as the potential biomarkers for Alzheimer’s disease: evidence from a systematic review 11/28/24

“Our results demonstrated that specific circulating miRNAs are consistently dysregulated in AD and could serve as non-intrusive biomarkers for the identification, prognosis, and prediction of cognitive decline.”

See for comparison: What is life when it is not protected from virus driven entropy 3/30/16

AI Overview:

When life is not protected from virus-driven entropy, it essentially means a state of rapid decay and eventual breakdown, where viruses actively disrupt the organized structures within living organisms, leading to a loss of function and ultimately death, as the natural tendency towards disorder (entropy) is significantly accelerated by viral infection. 

Key points to consider:

• Entropy and Life: Life inherently fights against entropy, maintaining organized structures through complex biological processes. 

Viruses as Entropy Accelerators:

Viruses, by replicating within cells and disrupting cellular functions, can rapidly increase the rate of entropy within an organism, leading to cellular damage and malfunction. 

Without Protection:

In the absence of immune responses or protective mechanisms against viruses, the body becomes vulnerable to widespread viral infection, leading to uncontrolled entropy and ultimately death. 

Examples:

• Untreated Viral Infections: A severe viral infection in an immunocompromised individual can quickly overwhelm the body’s defenses, causing rapid deterioration and death due to uncontrolled viral replication and cellular damage.
• Evolutionary Pressure: The constant threat of viruses has driven the evolution of immune systems in living organisms, which act as a defense against virus-driven entropy.

Claims that the immune system ‘evolved’ to protect organisms from viruses have not been supported by experimental evidence. See for comparison the claims linked from physics and chemistry to energy-dependent miRNA-mediated ecological adaptations across kingdoms:

Bacterial self-organization: co-enhancement of complexification and adaptability in a dynamic environment 5/7/03

Seeking the foundations of cognition in bacteria: From Schrödinger’s negative entropy to latent information 1/1/06

Learning from Bacteria about Natural Information Processing 10/15/09

Towards elucidating the connection between epithelial–mesenchymal transitions and stemness 12/6/14

Stability of the hybrid epithelial/mesenchymal phenotype 3/17/16

Toward understanding cancer stem cell heterogeneity in the tumor microenvironment 12/26/18

Don’t forget to choose facts instead of theories, or you may suffer unnecessarily and die prematurely from preventable or effectively treatable virus-driven diseases, such as Alzheimer’s.

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