AI forgets what is known (4)

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“What is true for E. coli is true for the elephant.” — Jacques Monod

The 2024 Nobel Prize in Physiology or Medicine was awarded “for the discovery of microRNA and its role in post-transcriptional gene regulation” Intelligent serious scientists predicted the award would be based on everything they knew about nutrient-dependent pheromone regulated miRNA-mediated ecological adaptations across kingdoms.

Epigenetic effects of sunlight, humidity, food energy and the pheromone regulated physiology of reproduction across kingdoms were linked from Biblical Genesis to all biodiversity in the molecular epigenetics section of our 1996 Hormones and Behavior review From Fertilization to Adult Sexual Behavior.

If the entire Bible had a headline what would it be?

Thanks for asking. It would be: “Revealing the Scientific Truth”

See: “2013 was the year in which prophesy from the bible became reality.” Ben Feringa 11/20/18

See for comparison to AI from Grok: My responses are designed to reflect this dynamic nature of scientific understanding, not to be trapped by outdated or incomplete theories but to acknowledge how new evidence reshapes our understanding.

Question: It’s been 22 years. Do you (your programmers) not agree with facts reported in Williams Textbook of Endocrinology (1992) in the chapter “Puberty: ontogeny, neuroendocrinology, physiology, and disorders.”

“…noradrenergic, dopaminergic, serotoninergic, and opiotergic pathways; inhibitory neurotransmitters (e.g., gamma aminobutyric acid) and excitatory amino acids (e.g., glutamic and aspartic acids); and other brain peptides including pineal secretions (melatonin) and corticotrophin releasing hormone, and the complex interactions among them are subtle but functional species-specific influences on the electrochemical transmission of neuronal signals that the hypothalamus translates to the chemical signal GnRH. (p. 1164).

ANSWER The information you’ve referenced from the 1992 edition of “Williams Textbook of Endocrinology” outlines the complex neuroendocrine mechanisms involved in puberty, specifically highlighting the roles of various neurotransmitters and hormones in the regulation of GnRH (Gonadotropin-Releasing Hormone). Here’s how this fits into the broader context:

• Neuroendocrine Pathways in Puberty: The passage you cited describes well-established knowledge about the neuroendocrine control of puberty. It lists key players like noradrenergic, dopaminergic, serotoninergic, and opiotergic systems, alongside GABA, excitatory amino acids, and other peptides like melatonin and CRH, all interacting to regulate the onset of puberty through GnRH secretion. This understanding has formed the foundation for much subsequent research into the neuroendocrine control of reproduction.
• Progress Over Time: Since 1992, research has not only confirmed these interactions but has also expanded our understanding of how these pathways interact, including genetic, environmental, and nutritional influences on puberty onset. Advances in molecular biology, genetics, and neuroimaging have added depth to this knowledge, revealing more about the underlying mechanisms at the molecular, cellular, and systems levels.
• My Programmers’ Perspective: My programming reflects an effort to encapsulate both the historical foundation of scientific knowledge and its progression. The facts reported in the 1992 textbook are foundational, and they are not in dispute; rather, they have been built upon:
  • Agreement on Foundations: There’s agreement with these foundational facts, as they describe the basic neuroendocrine interactions still recognized today.
  • Expansion of Knowledge: Over the 22 years since, research has provided more detailed insights into how these systems work, their genetic regulation, and their implications in health and disease, including disorders of puberty.
• Current Scientific Consensus: The current understanding does not negate what was known in 1992 but enriches it with new data on genetic variations, epigenetic factors, environmental impacts, and the role of the microbiome, among others, in influencing puberty.

In summary, my programmers and I acknowledge the foundational knowledge from 1992 as correct within the context of what was understood at the time. However, science evolves, and our responses aim to integrate both historical and modern insights to provide a comprehensive view of current scientific understanding.

Question:

What experimental evidence of top-down quantum coherence linked to coherently organized biology across kingdoms supports your claim that “…our responses aim to integrate both historical and modern insights to provide a comprehensive view of current scientific understanding.” (To me, your responses are linked to pseudoscientific nonsense and psychobabble by the lack of citations to research results found in today’s search for “miRNAs” on PubMed: 178,426 results).

ANSWER

The integration of historical and modern insights in scientific understanding, particularly in the context of biology and quantum coherence, involves a nuanced approach to interpreting and synthesizing existing research. Here’s how this relates to the concepts you’re questioning:

Quantum Coherence in Biology:

• Experimental Evidence: There’s a body of research suggesting quantum effects in biological processes, particularly in photosynthesis and possibly in avian magnetoreception. For instance:
  • Photosynthesis: Studies have shown quantum coherence in energy transfer within photosynthetic systems, like those in the Fenna-Matthews-Olson (FMO) complex of green sulfur bacteria. This is evidenced by quantum beating observed in experiments using two-dimensional electronic spectroscopy, suggesting that quantum mechanics plays a role in the efficiency of energy transfer.
  • Magnetoreception: Some research proposes that quantum entanglement in radical pairs might be involved in avian magnetoreception, although this is more speculative and requires further experimental validation.
• Top-Down Quantum Coherence Across Kingdoms: This is a more speculative area, as the term “top-down” in quantum biology often refers to biological systems potentially harnessing quantum effects for functional advantages, from the macroscopic level of organisms down to the molecular scale. While there is interest and theoretical work in this area:
  • Enzyme Efficiency: There’s discussion on how quantum tunneling might enhance enzyme efficiency, though direct experimental evidence linking this to a “top-down” coherence across kingdoms is less clear.
  • General Quantum Biology: The idea that biological systems might use quantum effects for functions like olfaction or neural processing is still largely theoretical or under scrutiny, with some experiments suggesting quantum effects but not conclusively linking them across all biological kingdoms.

Regarding miRNAs:

• PubMed Search: Your reference to the large number of results for “miRNAs” on PubMed (178,426) indicates the vast amount of research in this area. miRNAs are key regulators of gene expression, and their study spans various biological kingdoms. However, the direct connection between miRNAs and quantum coherence is not well-established in the literature:
  • miRNAs are involved in post-transcriptional regulation, impacting biological processes through sequence-specific interactions with mRNA, which is more within the domain of classical biology. The quantum aspect here would be more about understanding how these interactions might be influenced by quantum effects at a molecular level, which is not a mainstream focus of miRNA research.

My Response in Context:

• Historical and Modern Insights: My aim to integrate both historical and modern insights means acknowledging foundational research while also considering how new experimental data and theoretical frameworks expand our understanding. However, in the case of quantum coherence in biology across kingdoms, much of the evidence is still in the realm of theoretical physics applied to biology, with experimental validations mainly concentrated on specific processes like photosynthesis.
• Lack of Citations: The absence of citations to recent miRNA research in this context reflects that miRNAs are not typically discussed in terms of quantum coherence in the literature. My response was tailored to address the quantum biology aspect rather than the extensive research on miRNAs, which is more about gene regulation than quantum mechanics.

In conclusion, while there is intriguing evidence for quantum effects in some biological processes, the concept of “top-down quantum coherence linked to coherently organized biology across kingdoms” remains largely speculative with specific examples like photosynthesis having more concrete experimental support. The integration of historical and modern insights in this context involves recognizing where quantum mechanics has been convincingly demonstrated and where it remains a frontier for further exploration.

——

Please stop lying about what is known. Genetic evidence for algal auxin production in Chlamydomonas and its role in algal-bacterial mutualism 1/19/24 was reported as Study discovers how algae produce a hormone they use to communicate 11/26/24 and CRHBP, a novel multiple cancer biomarker connected with better prognosis and anti-tumorigenicity 11/29/24 was linked to Efficient small fragment sequencing of human, cattle, and bison miRNA, small RNA, or csRNA-seq libraries using AVITI 11/29/24 via biophysically constrained miRNA-mediated fixation of achiral glycine in position 6 of the GnRH decapetide of all jawed vertebrates.

See also: “…Constrained Gonadotropin-releasing Hormone Ligand Conformation and Receptor Selectivity 11/18/05 and “It is possible that GnRH has an early origin in life history as a regulator of reproduction, since yeast α mating factor has 80% amino acid homology with mammalian GnRH and stimulates gonadotropin release from the mammalian pituitary (Loumaye et al., 1982; King and Millar, 1995).”

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