miRNA-mediated transdifferentiation (4)

By: James V. Kohl | Published on: December 10, 2024

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Exosomal MiRNA Therapy for Central Nervous System Injury Diseases 12/9/24

“…covers the pathophysiology, animal models, miRNA transfection, administration methods, behavioral tests for evaluating treatment efficacy, and the mechanisms of action of miRNA-based therapies.”

For comparison to miRNA therapy in the context of chromosomal inheritance and the 2024 Nobel Prize in Physiology or Medicine “for the discovery of microRNA and its role in post-transcriptional gene regulation,” (10/7/24) see these three attempts to obfuscate what is known about effective treatment of cancers with microtubule inhibitors:

Coordinated inheritance of extrachromosomal DNAs in cancer cells 11/6/24

The chromosomal theory of inheritance dictates that genes on the same chromosome segregate together while genes on different chromosomes assort independently.

Origins and impact of extrachromosomal DNA 11/6/24

Extrachromosomal DNA (ecDNA) is a major contributor to treatment resistance and poor outcome for patients with cancer.

Enhancing transcription–replication conflict targets ecDNA-positive cancers 11/6/24

Transcription–replication conflict emerges as a target for ecDNA-directed therapy, exploiting a synthetic lethality of excess to treat cancer.

Attempts to obfuscate links from top-down quantum causation to coherently organized biology via fixation of amino acid substitutions in microtubules can be viewed in the context of:

Evolutionary GEM: Coevolution of Yuccas and Yucca Moths 1/7/18

“Yucca moths may have acquired adaptations as selection drove the populations to complement the unique template already established by yucca plants.”

and Causing a stink: reflections on my viral PhD 12/10/24

“…we are not used to thinking about smell critically, and the role of the thesis is to provide evidence that this is necessary.”

PZ Myers refused to examine the evidence when he attacked my scientific credibility in One crank dies, another rises to take his place 1/1/14

And he just keeps hammering away with his pseudo-scientific pronouncements.

Nutrient stress and social stress force organisms to adapt via seemingly futile cycles of protein biosynthesis and degradation that either result in amino acid substitutions that stabilize organism-level thermoregulation or the organism dies. It does not mutate into another species, which is why that cannot be explained to a high school freshman.

The point of this article was to show people that high school freshman have already been taught to believe in a ridiculous theory of mutation-initiated natural selection. Thus, they think everything that happens to DNA must be a mutation and there is plenty of extant literature that supports that idea. All of it is wrong in the context of ecological adaptations.

Based on Darwin’s ‘conditions of life’ ecological adaptations are nutrient-dependent and pheromone-controlled. The adaptations can be viewed as amino acid substitutions.

96 of them differentiate our cell types from those of most recent extinct ancestor.

Nutrient-dependent pheromone regulated ecological adaptations link constraints on viral replication to all biodiversity on Earth via light-matter interactions, miRNA-mRNA interactions, protein-protein interactions and miRNA-transcription interactions in species from cyanobacteria (pond scum), nematodes, and insects via 20 copies of p53 in cancer-free African elephants.

For a historical perspective, see: Human pheromones: integrating neuroendocrinology and ethology (2001) cited by ~169. For example: Analytical methods for the analysis of volatile natural products 4/17/23

“These compounds will vary at different healthy conditions, thus can potentially indicate occurrences of some diseases.35–37 One of the most promising and challenging applications in analysis of VOCs is the discovery of possible biomarkers for diseases, such as cancer.”

#35 is Human pheromones: integrating neuroendocrinology and ethology (2001)