miRNA-mediated transdifferentiation (10)

By: James V. Kohl | Published on: December 14, 2024

On 12/13/24, I returned home after singing Wayfaring Stranger at the American Legion Post 82 Karaoke in Ellijay, GA and found:

CircMYH9/miR-133a-3p/CXCR4 axis: a novel regulatory network in sperm fertilization and embryo development 12/13/24

“…provides valuable insights into the molecular mechanisms governing [ATP-dependent miRNA-mediated] sperm function and early embryonic development.”

It recapitulates the claims from the 2024 Nobel Prizes in Medicine, Physics and Chemistry. This year’s prizes in the “hard sciences” include facts linked to everything I’ve ever published or presented since 1992.

For example, see: From Fertilization to Adult Sexual Behavior (1996).

See also: What is life when it is not protected from virus driven entropy 3/30/16

AI Overview

According to the perspective of researcher James V. Kohl, “life when it is not protected” refers to a state where biological systems are not adequately shielded from the damaging effects of viruses, essentially leading to a breakdown in cellular function and ultimately, disease or death; essentially, the idea is that life cannot thrive without proper protection against viral “entropy” or disruption at the molecular level. 

Key points about this concept:

  • Virus-driven entropy: Kohl’s research focuses heavily on the idea that viruses can significantly disrupt the normal functioning of cells by stealing energy and causing imbalances in cellular processes, which he refers to as “virus-driven entropy.” 

Importance of immune system:

A healthy immune system acts as a protective mechanism against viruses, preventing them from causing widespread damage. 

Pathological consequences:

When this protection is compromised, the body becomes vulnerable to various diseases and pathologies.

See also: Energy as information and constrained endogenous RNA interference 2/15/17

AI Overview

“Energy as information and RNA interference” in the context of James Kohl’s work refers to the concept that energy can be viewed as a carrier of information within a biological system, with RNA interference (RNAi) acting as a key mechanism to regulate gene expression based on this “energy information” at the molecular level, essentially allowing cells to respond to energy fluctuations by adjusting protein production through RNAi pathways. 

Key points about this concept:

  • RNAi as a regulatory tool: RNAi is a natural process where small RNA molecules can bind to messenger RNA (mRNA), preventing it from being translated into proteins, effectively silencing gene expression. 

Energy-dependent RNAi:

Kohl suggests that the activity of RNAi pathways can be influenced by energy levels within a cell, meaning that changes in energy availability could trigger specific RNAi responses, thereby altering gene expression patterns. 

Information transfer:

By linking energy fluctuations to changes in gene expression via RNAi, Kohl proposes that energy can be considered as a form of information that the cell interprets and responds to. 

Potential applications:

  • Understanding cellular stress responses: Studying how energy levels affect RNAi could shed light on how cells adapt to stress conditions like nutrient deprivation or environmental changes. 

Therapeutic development:

Manipulating RNAi pathways could potentially be used to target specific genes and treat diseases related to energy dysregulation

See for comparison: The nature of the last universal common ancestor and its impact on the early Earth system 7/12/24 reported by the moronic theorist, Sabine Hossenfelder on 12/7/24 as Life Began Much Faster Than We Thought 12/7/24


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[…] facts linked to my 10-part series on miRNA-mediated transdifferentiation of cell types in all species via the 2024 Nobel Prize in Medicine and the Pivotal Role of […]


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