Panic-stricken theorists (5)

By: James V. Kohl | Published on: January 3, 2025

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SARCASM ALERT: “What could go wrong if the naturally occurring miRNA-mRNA balance was altered by theorists or drug-developers who never learned how mammalian cerebral cortex development was biophysically constrained by miRNA abundance?”

Because injections with modified mRNA alter the miRNA-mRNA balance, I asked GROK AI Is the mirna-mrna balance ATP-dependent

The answer: “…interaction between miRNA and mRNA isn’t primarily ATP-dependent.” 1/2/25

I added: Why are you lying about that? McEwen et al., (1964) reported that the Creation of RNA in regulatory T cells is ATP-dependent.

See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” 9/11/64

“The synthesis of RNA in isolated thymus nuclei is ATP dependent.“

In 2012, I learned that every aspect of biophysically constrained cell type differentiation in all tissues of all individuals of all species occurs downstream from miRNAs. The SFN New Orleans symposium speaker claimed that fact was discovered during the past 10 years. I was dumbfounded. Why hadn’t I learned that?

Another person attending the symposium candidly replied: “It’s a specialty field.” Since then, I confirmed that fact with others, including Bruce McEwen, my mentor, and followed the publication that mention miRNAs on PubMed. See: 179,504 results

For example: miR-1224 Controls Mammal Cerebral Cortex Development by Targeting the 3’-UTR of the Dlx1 mRNA 1/2/25

miRNA-mediated control of mammalian cell type differentiation links fixation of achiral glycine in position 6 of the gonadotropin releasing hormone (GnRH) decapeptide to the nutrient-dependent pheromone-regulated stability of organized genomes in all jawed vertebrates via the yeast model organism.

Jacques Monod extended that fact across kingdoms from E. coli to elephants. He said: “What is true for E. coli is true for the elephant.”

Theodosious Dobzhansky (1964) wrote: “Ingram and others found that hemoglobin S differs from A in the substitution of just a single amino acid, valine in place of glutamic acid in the beta chain of the hemoglobin molecule.”

For comparison, never forget: Generative AI is experimental.

College students returning after their Christmas Break will be faced with this fact: Naturally occurring energy-dependent fixation of amino acid substitutions in microtubules protects supercoiled DNA from the virus-driven degradation of messenger RNA (mRNA) in all organized genomes.

The focus on moronic theories can be viewed in the context of: Functionalized amino acids 52 results.

What are they? What do they do? Who thought they would be better than naturally occurring miRNA-mediated energy-dependent RNA interference?

A functionalized amino acid is an amino acid that has been modified with a biocompatible molecule. Functionalized amino acids have many applications, including:

Bioactive molecules N-functionalized amino acids are used to make peptides and other bioactive molecules.

Anticonvulsants

Functionalized amino acids (FAAs) are a class of anticonvulsant agents.

Polymers

Amino acids are used to make polymers with tailored properties, such as absorbable polymers with controlled release of molecules.

Carbon dioxide capture

Amino acids can be used to functionalize metal–organic frameworks (MOFs) to capture carbon dioxide.

Ion-selective switches

Amino acids can be used to make artificial membranes that can switch between selective transport of sodium and potassium ions.

Amino acids are the building blocks of proteins, and the body needs 20 different types to function properly. The body can make hundreds of amino acids, but it can’t make nine of them, which are called essential amino acids.

Functionalized amino acid anticonvulsants: synthesis and …We have described a new class of anticonvulsant agents, termed functionalized amino acids (FAAs, 1). 1. N-Benzyl-2-acetamidopropio…ScienceDirect.com