miRNA-mediated prevention (3)

By: James V. Kohl | Published on: January 13, 2025

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LIN-67 functionally interacts with heterochronic miRNAs and regulates developmental timing in Caenorhabditis elegans 1/2/25

AI-generated summary from ScienceCast

The study presents a significant advancement in understanding the molecular frameworks governing developmental timing in C. elegans. It identifies LIN-67 as a pivotal heterochronic gene that exerts negative regulation on miRNAs lin-4 and let-7. Loss-of-function analyses, including RNAi and mutant phenotyping, reveal that depletion of LIN-67 restores developmental timing and stage-specific gene expression in lin-4 and let-7 mutants while impacting seam cell proliferation and differentiation. The RNA-binding KH domain of LIN-67 was determined to be crucial for its nuclear localization and function, indicating RNA-dependent mechanisms in miRNA-mediated regulation. Notably, LIN-67’s interaction with ALG-1, a miRNA-specific Argonaute, suggests that it may serve as a balancing regulator of the miRNA landscape during developmental transitions, thus enriching the understanding of the molecular interactions influencing developmental timing.

For comparison to the balancing regulator of the miRNA landscape during developmental transitions, I asked Grok AI:

Do changes in the miRNA-mRNA balance link quantum coherence to coherently organized biology via the physiology of reproduction & the 2024 Nobel Prize “for the discovery of microRNA and its role in post-transcriptional gene regulation” + fixation of amino acids in microtubules?

This answer is like no answer at all.

“…the direct linkage to quantum coherence and microtubule amino acid fixation is speculative and not yet supported by a broad scientific consensus.”

See our section on molecular epigenetics in From Fertilization to Adult Sexual Behavior (1996) and the claims of other intelligent serious scientists about Vibrations in Microtubules (1997).

Remember, Grok AI’s foolish idea that there is a broad scientific consensus may be based on moronic theories that link the automagical emergence of energy from the cosmic void to the mathemagical evolution of people from pond scum via the limited amount of facts it can consider, compared in the contexts that have been linked to all animal models across kingdoms.

Thank God, the AI-generated summary from ScienceCast attests to the foolishness of those who believe that ‘science’ is done by consensus.

Watch these proponents of Intelligent Design and/or billions to millions of years of evolution who got caught with their moronic theories.

Stephen C Meyer

James Tour

See for comparison: What is life when it is not protected from virus driven entropy 3/30/16 and Energy as information and constrained endogenous RNA interference 2/15/17

Link Selective utilization of glucose metabolism guides mammalian gastrulation 7/18/23 from Richard E. Lenski’s foolish claims in his long-term evolution experiments to Jacques Monod’s claim that “What is true for E. coli is true for the elephant.” Help to stop racism in medical practice by linking Genetic Ancestry–Based Differences in Biomarker-Based Eligibility for Precision Oncology Therapies 1/9/25 to the Apology to People of Color for APA’s Role in Promoting, Perpetuating, and Failing to Challenge Racism, Racial Discrimination, and Human Hierarchy in U.S. 10/29/21

If you are not ready to apologize for the role you played by supporting moronic theories, just wait. Your career in academia ended when President-elect Trump linked sunlight and humidity to protection from coronavirus replication via

Intelligent serious scientists will not let you off the hook for causing the unnecessary suffering and premature deaths of their loved ones during the past few centuries since Merian linked the diet of caterpillars from their morphogenesis into moths to the nutrient-dependent pheromone regulated ecological adaptations in human populations from East Asia to North America during the past 6000 years.

See the video representation of Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant 2/14/13

Cry yourself to sleep if you chose the Democratic party to promote your views on anything.