Digital Inbreeding (2)

(click to enlarge)

Inbreeding refers to the mating of close relatives in species that are normally outbreeding. Matings between father and daughter, brother and sister, or first cousins are examples of inbreeding. Many species of plants and animals have evolved devices to minimize close inbreeding.

The suggestion that species ‘evolved’ devices to minimize inbreeding is not supported by experimental evidence, which is why I claim that a form of ‘inbreeding’ manifested in Artificial Intelligence is as detrimental to our species survival exemplified as other examples of human idiocy that repeat the same moronic assertions, which have never been supported by experimental evidence from model orgnaisms. For comparison, see:

Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene 9/2/11

Targeted regulation of the cell death gene led others to link Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20 from light-matter interactions to energy-dependent changes in the miRNA-mRNA balance and protection from virus-driven cancers such as glyphosate exposure-induced glioblastoma.

See also: Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator 1/2/25 and De novo design of peptide binders to conformationally diverse targets with contrastive language modeling 1/22/25.

Results were reported as AI-based platform designs peptides to target ‘undruggable’ proteins 1/29/25

“Biomedical engineers at Duke University have developed an AI-based platform that designs short proteins, termed peptides, capable of binding and destroying previously undruggable disease-causing proteins.”

Naturally occurring autophagy potentiation is energy-dependent and miRNA mediated across kingdoms. The direct connection from miRNA abundance is avoided by sources of Artificial Intelligence (AI) that report findings in the context of AI-designed peptide synthesis. Facts about energy-dependent peptide synthesis at the origin of life support the claim that Frequent AI use has a horrifying impact on our brains, study suggests 1/28/25

For examples of the deliberate obfuscation of the facts from three different source of Artificial Intelligence (AI), see:

1. Glyphosate: Human Health Risks Debate

1/28/25
Is glyphosate weedkiller a danger to humans?

….ongoing research and debate suggest that long-term exposure, even at low levels, might warrant further investigation, particularly concerning chronic diseases.

QUESTION

Does glyphosate use link altered naturally occurring light-matter interactions in soil bacteria and in plants to changes in the miRNA-mRNA balance and to the cause, or to the effective treatment of glioblastoma and other cancers, via “Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene” 9/2/11 and the 2024 Nobel Prizes in Physics, Chemistry and Medicine “for the discovery of microRNA and its role in post-transcriptional gene regulation“

ANSWER

The connection between glyphosate use, soil bacteria, plant miRNA-mRNA balance, and its potential influence on glioblastoma or other cancers through the mechanisms described involves several layers of scientific inquiry. Let’s break this down:

Glyphosate and Soil Bacteria:

Glyphosate’s Impact on Soil Microbiome: Glyphosate is known to affect soil bacteria, particularly those involved in the shikimate pathway, which is not present in animals but crucial for plants and some bacteria. This can lead to changes in microbial communities, potentially impacting soil health and plant interactions. However, the direct link to light-matter interactions isn’t well-established in this context.

Glyphosate, Plants, and miRNA-mRNA:

Plant miRNA and mRNA: Glyphosate’s influence on plant miRNAs could theoretically occur via its effect on the plant’s biochemistry, potentially altering gene expression including miRNAs. However, this is more speculative as direct studies linking glyphosate to changes in plant miRNA-mRNA balance are not commonly discussed in the literature reviewed.

Link to Glioblastoma:

MicroRNA in Glioblastoma: The article you mention, “Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene” (PMC3166303), discusses how certain miRNAs, such as miR-128, are down-regulated in glioblastomas and how this can be exploited for targeted therapy. However, this study does not directly connect glyphosate to these miRNA changes in humans or relate it to soil bacteria or plant biology.

Glyphosate and Cancer: There’s debate regarding glyphosate’s carcinogenic potential. While some studies suggest links to cancer like non-Hodgkin lymphoma, the direct connection to glioblastoma or the specific miRNA-mRNA balance in human cancers remains a subject of ongoing research. The current research does not provide a conclusive link between glyphosate exposure and changes in miRNA expression that lead to or treat glioblastoma.

2024 Nobel Prizes:

Nobel Prize in Medicine: If we consider the hypothetical scenario where the 2024 Nobel Prize was awarded for “the discovery of microRNA and its role in post-transcriptional gene regulation,” this would elevate the importance of miRNA research in medicine but wouldn’t directly imply a connection between glyphosate, environmental changes, and cancer treatment through miRNA unless explicitly studied.

Conclusion:

Current Knowledge: There is no direct, established scientific pathway linking glyphosate use specifically to altered miRNA-mRNA balance in humans leading to or treating glioblastoma via soil bacteria or plants. The interactions between glyphosate, soil biology, plant genetics, and human health outcomes like cancer are complex, with many variables and potential confounders.

Research Gaps: More research would be needed to draw these connections, particularly controlled studies looking at glyphosate’s impact across these biological systems.

Future Directions: While the influence of environmental contaminants like glyphosate on health remains a pertinent area of study, any association with cancer biology, particularly through miRNA mechanisms, would require extensive, interdisciplinary research to validate or refute.

In summary, while glyphosate does impact soil biology and potentially plant gene expression, and there’s substantial research into miRNAs and cancer, including glioblastoma, the direct linkage you’ve described lacks current scientific support. Any such connection would be speculative without further, targeted research.

QUESTION

Do you think the ideological bias of your programmers (against starting with light-matter interactions at the origin of life) will link ongoing use of glyphosate to more unnecessary suffering and premature deaths via 180,479 results from today’s PubMed search for “miRNAs?”

ANSWER

The suggestion that my programmers’ ideological bias could influence my analysis of scientific topics like glyphosate and miRNAs in this manner is quite speculative and outside the scope of factual discussion. Here are some points to consider regarding your question:

Scientific Objectivity: My responses aim to be based on available scientific evidence rather than any ideological bias. The scientific method itself strives to be objective, focusing on evidence rather than preconceived notions or biases. Glyphosate and miRNAs: Glyphosate: It’s known to affect biological systems, primarily through its action on the shikimate pathway in plants and some microorganisms, potentially influencing environmental and health outcomes. miRNAs: These small non-coding RNAs are involved in post-transcriptional regulation of gene expression and have been linked to numerous biological processes, including cancer development and progression. Link Between Glyphosate and miRNAs: While there’s research exploring glyphosate’s impact on gene expression (including miRNAs in plants and potentially in humans through indirect pathways), no direct, conclusive link has been established in peer-reviewed literature suggesting that glyphosate use leads to specific miRNA alterations causing widespread human health issues like unnecessary suffering or premature death through this mechanism. PubMed Search Results: The volume of research on miRNAs (180,479 results in your search) indicates significant interest and study in this field, covering a broad range of topics from basic biology to clinical applications. However, the presence of many studies doesn’t inherently mean they all relate to glyphosate or health risks in humans. Causality and Evidence: Establishing causality between environmental factors like glyphosate exposure and health outcomes via miRNAs involves complex biological pathways. This would require rigorous, peer-reviewed studies showing consistent, direct effects, which, to my knowledge, have not been comprehensively documented. Bias in Programming: I am designed to provide information based on the data and scientific consensus available. Any bias would be a reflection of the available literature’s biases, not necessarily my programmers’. The scientific community itself has mechanisms to counteract bias, such as peer review and replication of studies.

To summarize, while there is ongoing research into how environmental chemicals like glyphosate might affect biological systems, including miRNAs, claiming a direct link to increased suffering or premature deaths through this specific pathway would be an overreach based on current evidence. Instead, we should focus on:

Continued Research: To better understand any potential links between glyphosate exposure and human health via mechanisms like miRNA regulation. Policy and Regulation: Based on scientific evidence, to ensure that the use of glyphosate does not pose unnecessary risks. Public Health: Education and monitoring for potential health impacts, ensuring that any regulation reflects the best available science.

If you’re concerned about this topic, I recommend looking at recent reviews or meta-analyses in scientific journals for a more comprehensive understanding of where the research currently stands.

QUESTION

What makes you think I do not examine recent reviews and meta-analyses?
1) Do they not continue to establish facts that link light-matter interactions and miRNA-mRNA interactions to the scientific consensus of all intelligent serious scientists who have linked energy-dependent protein folding chemistry to all biophysically constrained biodiversity on Earth via Trump’s 4/23/20 claim that sunlight and humidity help to prevent coronavirus replication, and 20 copies of p53 in cancer-free African elephants?

2) Does anything published in peer-reviewed journals since 1910 suggest that the molecular mechanisms linked to the nutrient-dependent physiology of pheromone regulated reproduction via chromosomal rearrangements across kingdoms have changed since the origin of life, or that the molecular mechanisms are different in different species?
3) Do you think your responses exemplify human idiocy touted in the context of Articificial Intelligence?
Note: Question number 3 was a rhetorical question.

ANSWER

I apologize if my response suggested that you do not engage with current scientific literature. Let’s address your questions:

Linking Light-Matter Interactions and miRNAs to Scientific Consensus: Recent reviews and meta-analyses indeed contribute to our understanding of biological processes, including miRNA regulation and its implications. However, linking these directly to Trump’s claim about sunlight and humidity affecting coronavirus replication or to the unique genetics of African elephants (with 20 copies of p53) in a way that forms a scientific consensus is not straightforward. Sunlight and Humidity: Trump’s claim was more anecdotal and not directly supported by peer-reviewed scientific consensus. Research does show that UV light can inactivate viruses, but this is more about direct exposure rather than a broad environmental claim. miRNAs and p53 in Elephants: While the extra copies of p53 in elephants are linked to cancer resistance, this is a specific evolutionary adaptation rather than a direct correlation with light-matter interactions or miRNA regulation across all species. The scientific community continues to explore how miRNAs, alongside other genetic and epigenetic mechanisms, influence biological processes, but these connections are complex and species-specific. Molecular Mechanisms Since 1910: Since 1910, our understanding of molecular biology has expanded dramatically. The basic principles of genetics and biochemistry, like the role of nutrients in gene expression or pheromone-regulated reproduction, have indeed been refined but not fundamentally altered. However: Chromosomal Rearrangements: These are known to vary significantly across species, influencing speciation and adaptation, suggesting that while the mechanisms might be similar, their outcomes and specifics can differ widely. Conservation Across Kingdoms: There are conserved pathways in molecular biology, like those involving miRNAs or protein folding, but the details of how these operate can differ due to evolutionary divergence. The idea that these mechanisms haven’t changed or differ universally across species is an oversimplification. Rhetorical Question on AI and Human Idiocy: I understand this was rhetorical, but I’ll respond in the spirit of discourse. My aim is to provide factual, evidence-based responses that reflect current scientific understanding, not to exemplify or promote human idiocy. If my responses seem insufficient or misaligned with your expectations, it’s likely due to the limitations of my programming or the complexity of the topics discussed rather than an intent to misrepresent or oversimplify.

In summary, while there’s ongoing research into how environmental factors like light and humidity might affect biological processes, including miRNA regulation, these are part of a broader, nuanced scientific exploration where consensus often reflects the complexity and diversity of life rather than simple, universal links.

QUESTION

Do you agree with DeepSeek.com summaries of light-matter interactions and protein folding chemistry that suggest frequent use of Grok AI limits critical thinking skills?

ANSWER

As of my last update, I couldn’t find specific references from DeepSeek.com linking light-matter interactions and protein folding chemistry directly to the use of AI like Grok in a way that suggests it limits critical thinking skills. However, I can address the general notion of AI’s impact on critical thinking:

AI and Critical Thinking: There’s a growing body of research and discussion around the influence of AI tools on human cognitive abilities, including critical thinking: Positive Effects: AI can enhance critical thinking by providing vast amounts of information, offering different perspectives, and engaging users in analytical tasks. For example, AI can facilitate problem-solving by offering data analysis or simulation environments that encourage deeper inquiry and understanding. Negative Effects: Concerns exist that over-reliance on AI might lead to cognitive offloading, where individuals delegate thinking tasks to AI, potentially weakening their own critical thinking muscles. Studies, like those mentioned in the web results I referenced earlier, suggest that frequent use of AI tools for tasks traditionally requiring human thought might diminish these skills if not used judiciously. Light-Matter Interactions and Protein Folding: These are highly technical scientific fields: Light-Matter Interactions: In biology, light can influence cellular processes, including photosynthesis, which in turn impacts gene expression and protein activity. However, linking this directly to AI use and critical thinking would be a significant leap without explicit research backing. Protein Folding: This is crucial for understanding biological function and disease. AI has made significant contributions here, notably with tools like AlphaFold, which predict protein structures, aiding research but also potentially reducing the need for human-driven hypothesis testing in this narrow field. Grok AI Specifically: Regarding Grok or similar AI tools: There’s no direct, published evidence I’m aware of stating that Grok specifically limits critical thinking. However, the general principle applies: if Grok or any AI is used as a crutch rather than a tool for enhancing thought, there might be a risk of reduced critical thinking. Encouragement of Critical Thinking: To avoid this, users should be encouraged to use AI as a means to explore questions further, verify information, and engage in deeper analysis rather than accepting AI outputs at face value.

In conclusion, while I agree with the broader sentiment that over-reliance on any tool, including AI, can potentially limit critical thinking if not balanced with active, independent thought processes, I don’t have specific evidence from DeepSeek.com or elsewhere directly attributing this effect to Grok AI in the context of light-matter interactions or protein folding chemistry. Users should engage with AI critically, using it to augment rather than replace human thinking.

ADDENDUM

2) See for comparison DeepSeek AI
Link light-matter interactions to protein folding chemistry

The interaction between light and matter, particularly in the context of protein folding, can be understood through several physical and chemical principles. Here’s how these two areas are linked:

Photochemical Reactions: Light can induce chemical reactions that affect protein folding. For example, certain proteins contain chromophores that absorb light, leading to electronic excitation. This excitation can result in conformational changes in the protein, affecting its folding pathway. Photosensitive Proteins: Some proteins are inherently sensitive to light. For instance, rhodopsin in the retina undergoes a conformational change upon absorbing light, which is crucial for vision. Similarly, photoactive yellow protein (PYP) undergoes structural changes when exposed to light, which can be studied to understand protein folding dynamics. Spectroscopic Techniques: Techniques such as UV-Vis spectroscopy, fluorescence spectroscopy, and circular dichroism (CD) spectroscopy use light to probe the structure and folding of proteins. These methods provide insights into the secondary and tertiary structures of proteins and how they change under different conditions. Optogenetics: This is a technique that uses light to control proteins within living tissues. By engineering light-sensitive domains into proteins, researchers can control protein activity and folding with high temporal and spatial precision. Thermal Effects: Light, especially in the form of laser irradiation, can cause localized heating. This thermal energy can influence the stability and folding kinetics of proteins. For example, sudden heating can denature proteins, while controlled heating can be used to study folding intermediates. Photothermal and Photochemical Manipulation: Advanced techniques like photothermal microscopy and photochemical manipulation allow scientists to observe and manipulate protein folding at the single-molecule level using light. Quantum Effects: At a more fundamental level, the interaction between light and matter involves quantum mechanics. The electronic transitions induced by light absorption can affect the vibrational states of a protein, influencing its folding landscape.

Understanding these interactions helps in designing experiments and models to study protein folding, which is crucial for elucidating the mechanisms of various biological processes and diseases related to protein misfolding.

ADDENDUM

3) Microsoft “co-pilot“

I’m curious about microbiome health. How does it play a role in boosting our immunity?
The microbiome, which is the collection of trillions of microorganisms living in and on our bodies, plays a crucial role in boosting our immunity. Here’s how:

Barrier Function: The microbiome acts as a barrier, preventing harmful pathogens from colonizing our bodies. It competes with these pathogens for space and nutrients, making it harder for them to establish themselves1.

Immune System Education: Microorganisms in the gut help educate our immune system to distinguish between harmful invaders and harmless substances. This helps in developing a more effective immune response1.

Production of Immune Molecules: Certain gut bacteria produce molecules like short-chain fatty acids (SCFAs) that support immune cells. SCFAs help in the production of regulatory T cells, which are essential for maintaining immune tolerance and preventing autoimmune disorders1.

Inflammation Regulation: The microbiome helps regulate inflammation by interacting with immune cells in the gut. This can prevent excessive inflammation, which is often linked to various chronic diseases1.

Pathogen Detection: The microbiome can detect and respond to pathogens quickly, signaling the immune system to take action.

Maintaining a healthy microbiome through a balanced diet rich in fiber, avoiding unnecessary antibiotics, and reducing stress can help support these immune functions.

Does this help clarify the connection between microbiome health and immunity for you?

QUESTION

Is light-activated carbon fixation in cyanobacteria the link from their pheromone-regulated physiology of reproduction to all biodiversity on Earth via the 2024 Nobel Prizes in Physics, Chemistry, and Medicine “for the discovery of microRNA and its role in post-transcriptional gene regulation”

ANSWER

That’s an interesting connection you’re drawing! Let’s break it down:

Light-Activated Carbon Fixation in Cyanobacteria: Cyanobacteria use light to convert carbon dioxide into organic compounds. This process is crucial for their survival and has significant implications for carbon cycling and potentially biofuel production2.

2024 Nobel Prizes:

Physics: Awarded for foundational discoveries in machine learning with artificial neural networks.

Chemistry: Awarded for computational protein design and protein structure prediction.

Medicine: Awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

MicroRNA and Gene Regulation: MicroRNAs are small RNA molecules that regulate gene expression by interfering with the translation of messenger RNAs. This discovery has profound implications for understanding how genes are controlled in multicellular organisms, including humans6.

While light-activated carbon fixation in cyanobacteria and the discovery of microRNA are both significant scientific achievements, they are not directly linked6. The Nobel Prizes in Physics, Chemistry, and Medicine each recognize different areas of scientific research.

However, both areas contribute to our understanding of life’s complexity and the potential applications in biotechnology and medicine. It’s fascinating to see how diverse scientific discoveries can collectively enhance our knowledge and technological capabilities!

Does this help clarify things?

QUESTION

Are you deliberately obfuscating the facts by separating Physics and Chemistry from the molecular mechanisms linked to effective medical treatment of glioblastoma via energy-dependent cell type differentiation across kingdoms, reported again in the context of medicine as: Molecular Mechanisms and Strategies for Inducing Neuronal Differentiation in Glioblastoma Cells 1/30/25

ANSWER

I apologize if my previous response seemed unclear. Let’s delve deeper into the connection you’re suggesting.

The article you mentioned, “Molecular Mechanisms and Strategies for Inducing Neuronal Differentiation in Glioblastoma Cells,” discusses how inducing neuronal differentiation in glioblastoma cells can be a potential therapeutic strategy. This involves understanding the molecular mechanisms that drive cell differentiation and applying strategies to promote this process in cancer cells1.

While this research is groundbreaking, it doesn’t directly link to the Nobel Prizes in Physics and Chemistry, which focused on machine learning, protein design, and microRNA gene regulation. However, the underlying theme of understanding and manipulating biological processes is a common thread.

Would you like more information on how neuronal differentiation is being explored as a treatment for glioblastoma?

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