Digital Inbreeding (7)

By: James V. Kohl | Published on: February 4, 2025

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Antagonistic AI 2/12/24 presciently summarized the problem with responses from X’s Grok AI. The responses consistently fail to link energy-dependent changes in miRNAs to biophysically constrained protein folding chemistry via the 2024 Nobel Prizes in Physics, Chemistry and Medicine for the discovery of microRNA and its role in post-transcriptional gene regulation.

Instead, Grok AI starts with the claim that the energy was always there; it did not automagically emerge from the cosmic void. The intent of that moronic form of antagonism can be viewed in the context of many more facts about how the miRNA-mRNA balance is linked to energy-dependent protein folding chemistry.

For instance, a carbon-12 atom has 6 protons, 6 neutrons, and 6 electrons. Light-activated fixation of carbon-12 in cyanobacteria links the ATP-dependent Creation of RNA in regulatory T-cells to biophysically constrained protein folding chemistry and protection from viruses across kingdoms via the physiology of reproduction. See: Nutrient-dependent/pheromone-controlled adaptive evolution: a model 6/14/13.

Grok AI pitted the criticisms of an undergraduate nursing student against the facts I detailed in a peer-reviewed publication by citing Criticisms of the nutrient-dependent pheromone-controlled evolutionary model 6/4/14

The journal editor’s response clarified the facts in the context of peer-review:

Editor’s note

“The 2013 review article by James Vaughn Kohl published in Socioaffective Neuroscience & Psychology and criticized in the above Letter to the Editor was subjected to standard peer review and the revised version was accepted by me after it had been accepted by both reviewers.”

Read more in the conclusion from this Grok Conversation

Conclusion: Yes, linking comments from relatively uneducated college students to peer-reviewed models of complex scientific concepts like energy-dependent miRNA-mediated pathology could exemplify both the antagonism and obfuscation of AI. It challenges the established scientific discourse (antagonism) and potentially clouds the clarity of scientific information (obfuscation). However, the effectiveness and appropriateness of such a strategy would depend on the intent behind it—whether it’s to educate, provoke thought, or simply to stir controversy.

Pretending to use a strategy without naming it, or placing it into the context of questions and answers serves no purpose except to antagonize intelligent serious scientists.

For example, biologically uninformed theorists may argue against the facts linked to God’s Creation at the origin of life, but they cannot explain either the origin of energy, or the origin of the sense of smell, which links food odors and pheromones to the physiology of reproduction in all extant species via what is known about protection from the virus-driven degradation of mRNA at every level of examination.

See: Regulating Nrf2 activity: ubiquitin ligases and signaling molecules in redox homeostasis 1/27/25

“The proximity of cysteines in proteins to basic amino acids such as arginine, the presence of hydrogen bond donors, and location at the N-terminal end of an α-helix are likely to favor ionization of the thiol group, and thus their reactivity, whereas proximity to aspartic acid or glutamic acid favors protonation of the thiol group [180].”

The facts are not linked to theories about mutation-driven evolution. Instead, they are linked to the extant literature, such as Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20, which was linked to the potential of effective treatment of glioblastoma in Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene 9/2/11

See also: Extracellular viral microRNAs as biomarkers of virus infection in human cells 12/31/24
Detection of extracellular viral miRNAs links cell-free candidate biomarkers of live, latent & reactivated virus infections from the 2024 Nobel Prizes in Physics, Chemistry & Medicine to effective treatment of all virus-driven pathology.

and, Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites 2/3/25

“…ginger-derived exosome-like nanoparticle (GELN) preferentially taken up by Lachnospiraceae and Lactobacillaceae mediated by digalactosyldiacylglycerol (DGDG) and glycine, respectively. We further demonstrate that GELN aly-miR159a-3p enhances anti-PD-L1 therapy in melanoma by inhibiting the expression of recipient bacterial phospholipase C (PLC) and increases the accumulation of docosahexaenoic acid (DHA). An increased level of circulating DHA inhibits PD-L1 expression in tumor cells by binding the PD-L1 promoter and subsequently prevents c-myc-initiated transcription of PD-L1.”

Further attempts to obfuscate the facts or antagonize scientists who have published 180,733 results in indexed journal articles that mention the role that miRNAs play in linking what organisms eat to the metabolism of food to pheromones that link reproduction to all energy-dependent differences in every species on Earth may involve criminal charges against the promoters of nonsense presented in the context of AI.

The promoters of nonsense have been placed on notice of likely charges after publication of MicroRNAs affect GPCR and Ion channel genes needed for influenza replication 11/17/21 and Antiviral agents and therapeutics against respiratory viruses 9/8/24