Holding AI accountable (3)

By: James V. Kohl | Published on: March 6, 2025

A double-agent microRNA regulates viral cross-kingdom infection in animals and plants 3/5/25

miRNA abundance protects all organized genomes from the virus-driven degradation of mRNA and all pathology.

See also: Elevated levels of intracellular RNA lariats suppress the antiviral response 12/8/24 Reported as Intron-Derived Lariat RNAs Go Stable 3/4/25

“During pre-mRNA splicing, introns are removed by the spliceosome, and the flanking exons are ligated to form mature mRNA, which is subsequently translated into protein…. we provide an overview of the life cycle of intron-derived lariat RNAs, focusing on their biogenesis, degradation, and retention. We also discuss the mechanisms that enable their resistance to degradation and the biological functions of stable lariat RNAs, shedding light on these seemingly “nonsense” yet inevitably produced non-coding intronic RNAs.”

The term pre-mRNAs changed to miRNAs in the late 1990s. See how the change in terms led to the claims from the 2024 Nobel Prizes in Physics, Chemistry, and Medicine for the discovery of microRNA and its role in post-transcriptional gene regulation to all biodiversity on Earth via light-activated carbon fixation in cyanobacteria and the physiology of pheromone-regulated reproduction across kingdoms and effective treatment of all virus-driven pathology.

These facts about biophysically constrained viral latency are not new. See:

Modeling with uncertainty quantification reveals the essentials of a non-canonical algal carbon-concentrating mechanism 2/7/25

Spatial Regulation of Rice Leaf Morphology by miRNA-Target Complexes During Viral Infection 3/5/25

Preclinical Alzheimer’s disease shows alterations in circulating neuronal-derived extracellular vesicle microRNAs in a multiethnic cohort 3/5/25

My 3/6/25 search of PubMed for articles that mention miRNAs returns 181,834 results that link light-activated miRNA abundance at the origin of life to all biodiversity via Natural compounds as regulators of miRNAs: exploring a new avenue for treating brain cancer 3/6/25, claims from Clinical Applications of Oligonucleotides for Cancer Therapy 3/5/25, and protection from the virus-driven degradation of mRNA in organized genomes via 20 copies of p53 in cancer-free African elephants and the nutrient-dependent pheromone regulated physiology of reproduction in insects via Insect pheromone in elephants 2/22/96.


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