Holding AI accountable (6)

By: James V. Kohl | Published on: March 10, 2025

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Excerpt from today’s Grok (built by xAI) profile of me @microRNApro:

James V. Kohl…ties subatomic particles to healthy ecosystems…MicroRNApro’s…linking elephant p53 to cancer-free vibes and light-powered life from plants to people

Grok and X are currently having technical difficulties. See: Elon Musk’s X Crashes Globally. Is this because Grok lied about facts known to all intelligent serious scientists about nutrient-dependent pheromone regulated cancer prevention? See for instance: “How p53 modulates the tumor immune microenvironment” 3/4/25

Twenty copies of p53 in cancer-free African elephants link food energy-dependent pheromone controlled feed back loops to their physiology of reproduction across kingdoms via these four indexed published works and the 2024 Nobel Prizes in Physics, Chemistry, and Medicine for the discovery of microRNA and its role in post-transcriptional gene regulation

See:

Insect pheromone in elephants (1996)

From Fertilization to Adult Sexual Behavior (1996)

Vibrations in Microtubules (1997)

Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013)

… and ~181,940 indexed publications that mention miRNAs, in the context of Google AI’s review of “Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems” (2018)

Abstract: “Energy dependent angstroms to ecosystems” refers to a concept that explores how the smallest unit of measurement, an angstrom (a unit of length used in atomic and molecular scales), can be influenced by energy levels, ultimately impacting the dynamics and interactions within an entire ecosystem, highlighting the interconnectedness of life from the microscopic to the macroscopic level.

Key points to understand this concept:

Angstrom scale: At the angstrom level, we are looking at the structure of molecules, including the arrangement of atoms within them.

Energy dependence:

The behavior of molecules and their interactions are highly dependent on the energy they possess, which can be affected by factors like temperature, light, and chemical reactions.

Biological implications:

Changes in molecular structure at the angstrom level can directly impact biological processes like protein folding, enzyme activity, and cell signaling, which are crucial for organismal function.

Example applications:
Photosynthesis: The absorption of light by chlorophyll molecules within plant chloroplasts, which occurs at the angstrom scale, is the initial step in photosynthesis, a key process for the entire ecosystem.

Climate change:

The structure of greenhouse gases, like carbon dioxide, at the molecular level (angstroms) influences their ability to trap heat, impacting global climate patterns.

Evolutionary adaptation:

Slight changes in protein structure due to genetic mutations (occurring at the angstrom level) can lead to different functional adaptations within an organism, impacting its ecological niche.

How it connects to ecosystems:

Biogeochemical cycles: The movement of elements through an ecosystem, like carbon or nitrogen, is driven by chemical reactions occurring at the molecular level, which are ultimately affected by energy levels.
Species interactions: The ability of an organism to interact with another, whether through predation, competition, or symbiosis, can be influenced by the molecular interactions between their cells at the angstrom scale.
Environmental stress: Changes in environmental conditions (temperature, pH) can alter molecular interactions at the angstrom level, impacting organismal physiology and ecosystem stability.

If not for the anti-Christian ideological bias of Grok, built by xAI, you might already know that biophysically constrained energy-dependent biogeochemical cycles of protein folding chemistry link species interactions across kingdoms from microbes to mammals, and to ecosystem stability via prevention of stress-linked virus-driven degradation of mRNA.

Updates: See: “Interleukin-34-orchestrated tumor-associated macrophage reprogramming…driven by p53 inactivation” 10/8/24 It links light-activated miRNA abundance at the origin of life to “The role of miR-16 and miR-34a family in the regulation of cancers” 2/28/25 indexed 3/10/25

For DeepSeek AI’s confirmation of that fact, see:

Does light-regulated humidity and pH-dependent microRNA biogenesis significantly influence gene expression and development across various organisms, including microbes, plants, and animals via miRNA abundance?

Yes, light-regulated humidity and pH-dependent microRNA (miRNA) biogenesis can significantly influence gene expression and development across various organisms, including microbes, plants, and animals, by modulating miRNA abundance. Here’s how these factors play a role:

Light-Regulated Humidity and miRNA Biogenesis Plants: Light and humidity are critical environmental factors that influence plant growth and development. Light regulates the expression of genes involved in miRNA biogenesis, and humidity affects stomatal closure and transpiration, which can indirectly influence cellular conditions like pH and redox state. These changes can alter the processing and stability of miRNAs, which in turn regulate genes involved in stress responses, development, and metabolism. Animals: While animals are less directly influenced by environmental humidity, light (e.g., circadian rhythms) can regulate miRNA expression in tissues like the retina or brain. miRNAs influenced by light can modulate genes involved in circadian clock regulation, metabolism, and behavior. Microbes: In microbes, light and humidity can affect miRNA-like small RNAs (sRNAs) that regulate gene expression in response to environmental changes. For example, in photosynthetic bacteria, light-dependent sRNAs can influence metabolic pathways and stress responses.
pH-Dependent miRNA Biogenesis Plants: Cellular pH can fluctuate due to environmental stressors like drought, salinity, or light intensity. These pH changes can affect the activity of enzymes involved in miRNA processing, such as Dicer-like proteins, leading to changes in miRNA abundance. This, in turn, influences the expression of target genes involved in stress adaptation and development. Animals: In animals, pH changes in cellular compartments (e.g., endosomes or lysosomes) can influence miRNA maturation and stability. For example, acidic conditions in tumor microenvironments can alter miRNA profiles, affecting cancer-related gene expression. Microbes: pH-dependent regulation of sRNAs in microbes can influence gene expression in response to environmental pH changes, such as those encountered in host-pathogen interactions or during fermentation processes.
Impact on Gene Expression and Development miRNA Abundance: Changes in miRNA abundance due to light, humidity, or pH can have cascading effects on gene expression. miRNAs typically bind to complementary mRNA sequences, leading to mRNA degradation or translational repression. This post-transcriptional regulation fine-tunes gene expression and is crucial for development, stress responses, and homeostasis. Cross-Organism Effects: The conservation of miRNA pathways across eukaryotes means that similar mechanisms can influence development and gene expression in microbes, plants, and animals. For example, miRNAs involved in stress responses or developmental timing often have conserved roles across species.
Examples Plants: miR398 is regulated by light and oxidative stress, targeting genes involved in copper homeostasis and stress responses. Animals: miR-132 is light-regulated and plays a role in neuronal plasticity and circadian rhythms. Microbes: sRNAs in bacteria like E. coli are regulated by environmental pH and influence stress response genes.

In summary, light-regulated humidity and pH-dependent miRNA biogenesis are important mechanisms that influence gene expression and development across diverse organisms by modulating miRNA abundance. These regulatory pathways help organisms adapt to environmental changes and maintain developmental precision.