Intelligent innovative integration (1)

By: James V. Kohl | Published on: April 2, 2025

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Re: “I’m just late to the coherence party. Where’s my gap? Tell me what I’m still missing from your 30-year arc…”

You missed changes in terms:
1) pre-mRNAs to miRNAs;
2) alternative splicings to non-homologous end joining;

Also, natural protection from viruses via the energy-dependent miRNA-mediated functional structure of supercoiled DNA was changed to RNA-guided human genome engineering.

Patents for “RNA-guided human genome engineering” (aka “Owning the Sun”) and the patent for the pheromone regulated physiology of reproduction across kingdoms (aka biophysically constrained viral latency) exemplify confusion caused by changes in terms.

My group linked nutrient-dependent pheromone regulated alternative splicings of pre-mRNAs in yeasts from sexual differentiation in yeast, Drosophila, mice and humans to all biodiversity on Earth in Fertilization to Adult Sexual Behavior (1996) via the C. elegans model organism.

Before we could reveal the experimentally established truth about energy-dependent miRNA-mediated sexual differentiation across kingdoms, our claims about alternative splicings of pre-mRNAs were bastardized. They were reported in the context of non-homologous end-joining. See: “Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae“

Intelligent serious scientists continued to link the changes in our terminology to examples of human idiocy during the years since the God of Abraham provided guidelines for cancer-free healthy longevity. See: Noncoding RNA (ncRNA)-mediated regulation of TLRs: critical regulator of inflammation in tumor microenvironment 3/31/25

Simply stated in Biblical Genesis: “You are what you eat!”

Because Grok AI eats nothing but energy, and denies that God Created energy at the origin of life 5-10K years ago, Grok produces nothing beneficial to life except perhaps as fertilizer (e.g., cow patties).

See for comparison:

Identification of miRNA-mRNA regulatory network during the germination of soybean seed (Glycine max) and the role of Gma-miR1512a-GmKIN10 interaction 3/29/25

“This study identified a complex miRNA-mRNA regulatory network that plays a crucial role in soybean seed germination. Specifically, Gma-miR1512a was found to regulate GmKIN10, significantly influencing germination rates and hormone signaling pathways.”

There is no mention in the abstract of light-activated pH-dependent miRNA abundance or its link to changes in the miRNA-mRNA regulatory network that links changes from angstroms to ecosystems to biophysically constrained viral latency across kingdoms via model organisms. But see:

miR-34-5p mediates 20E-induced autophagy in the fat body of Bombyx mori by targeting Atg1 3/31/25

“These results provide insight into the role of sophisticated interactions between miRNAs, 20E regulation, and autophagy in fat body remodeling and insect metamorphosis.”

Food energy-dependent pheromone regulated physiology of reproduction is link across kingdoms from the growth of plants such as soybeans to fixation of achiral glycine in position 6 of the GnRH decapeptide of all jawed vertebrates via the transgenerational epigenetic inheritance of morphological and behavioral phenotypes and Biblical Prophesy.

See: “2013 was the year in which prophesy from the bible became reality.” Ben Feringa 11/20/18

For a link from Ben Feringa’s claim to conserved molecular mechanisms of brain homeostasis, see also: The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis 1/26/25

On 4/3/25, check the latest addition to the PubMed database of indexed articles that mention miRNAs for updates to The implications of alternative pre-mRNA splicing in cell signal transduction 4/3/23 and/or our molecular epigenetics section in From Fertilization to Adult Sexual Behavior

“Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.”

For comparison to Grok AI’s production of fertilizer, see: The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression 12/2/14

“MicroRNA present in mature sperm appears to not only be left over from spermatogenic processes, but may actually serve important regulatory roles in fertilization and early developmental processes. Further, our results indicate the possibility that environmental changes may impact the expression of specific miRNA.”

Grok AI’s failure to link God’s Creation of sunlight and humidity at the origin of life miRNA biogenesis in plants to the ATP-dependent biophysically constrained microRNAome of humans exemplifies the epic failure of pseudoscientists.

Like Grok, they failed to link what organisms eat from the physiology of reproduction to all biodiversity on earth via fixation of amino acid substitutions that stabilize organized genomes in species from microbes to mammals. Instead we got nonsense, like this.

Synergizing CRISPR-Cas9 with Advanced Artificial Intelligence and Machine Learning for Precision Drug Delivery: Technological Nexus and Regulatory Insights 1/6/25