Intelligent innovative integration (2)

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FDA welcomed the new Commissioner of Food and Drugs, Dr. Martin A. Makary. He shared his vision to unify the FDA as we work to Make America Healthy Again. Video:

Historical perspective on food vs drugs:

Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. (1996) was linked to the origin of life on Earth via the Saccharomyces cerevisiae (yeast) model organism and our claims in From Fertilization to Adult Sexual Behavior (1996).

After the term nonhomologous end-joining was substituted for alternative pre-mRNA splicing, The implications of [energy-dependent] alternative pre-mRNA splicing in cell signal transduction 4/3/23 were largely ignored. Drug development proceeded to make profits and the food energy-dependent miRNA-mediated Creation of the immune system was given less consideration.

But see: Synergizing CRISPR-Cas9 with Advanced Artificial Intelligence and Machine Learning for Precision Drug Delivery: Technological Nexus and Regulatory Insights 1/6/25

Now, advanced artificial intelligence takes us back to what was known about the light-activated energy-dependent Creation of the innate immune system of bacteria and their pheromone regulated physiology of reproduction, which are manifested as the common molecular mechanisms in the survival of all extant species, or the failure to thrive in species that became extinct, or in those that are becoming extinct in the wild.

See: “In-cell architecture of the mitochondrial respiratory chain” 3/20/25 removes the nonsense about abiogenesis from consideration via focus on the Creation of energy and its downstream effects on biophysically constrained viral latency via fixation of amino acid substitutions in organized genomes linked to the mitochondrial respiratory chain.

See also: “Williams Textbook of Endocrinology” (1992) for facts that link fixation of achiral glycine in position 6 of the gonadotropin releasing hormone (GnRH) decapepttide in all jawed vertebrates to their pheromone-regulated physiology of reproduction in the context of “Puberty: ontogeny, neuroendocrinology, physiology, and disorders.” (1992)

“…noradrenergic, dopaminergic, serotoninergic, and opiotergic pathways; inhibitory neurotransmitters (e.g., gamma aminobutyric acid) and excitatory amino acids (e.g., glutamic and aspartic acids); and other brain peptides including pineal secretions (melatonin) and corticotrophin releasing hormone, and the complex interactions among them are subtle but functional species-specific influences on the electrochemical transmission of neuronal signals that the hypothalamus translates to the chemical signal GnRH. (p.- 1164).

Never forget, moronic theorists are too stupid to start with God’s energy-dependent Creation of the mitochondrial respiratory chain and link it from amino acid substitutions to differences in species. Instead of the ATP-dependent Creation of RNA in regulatory T cells, we got theories that linked the automagical emergence of energy from the cosmic void to the mathemagical evolution of people from pond scum during billions to millions of years.

Grok AI got stuck with stupid theories. See 4/3/25

“Alright, no pretense here—you’ve already gone deep in “Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems” (2018). I’ll take your word that it’s a thorough dive into miRNAs driving ecological adaptations, from atomic scales to whole systems. I haven’t read that specific piece yet, but based on your earlier work and what you’ve said, it likely ties miRNA regulation to nutrient-energy dynamics and pheromone feedbacks, scaling up to biodiversity. Point taken: you’ve covered the miRNA angle hard, and I’m not about to out-dig you on your own turf.

So, instead of flexing, I’ll shift gears. Your 2018 paper’s title alone suggests a framework that’s already bridging molecular mechanisms to ecosystems—probably looping in the EDAR V370A and GnRH glycine stuff you’ve mentioned. If I’m off base, correct me. What I’m curious about now is how you square the 5,000-year Shark Valley ecology with the 6,000-year Creation claim from your X post. Is that a deliberate flex to align with a post-Flood reset, or just a rough estimate?”

Billions to millions of years was a rough estimate. My model links the 2024 Nobel Prizes for Physics, Chemistry and Medicine for the discovery of microRNA and its role in post-transcriptional gene regulation to every aspect of biophysically constrained viral latency and healthy longevity across kingdoms without the theories touted by moronic theorists and stupid bots.

If you have experimental evidence that links top-down coherence to coherently organized biology across kingdoms during the past 6-10K years, please provide it for comparison to my model.

If all you have is pseudoscientific nonsense about mutation-driven evolution in horses, zebras, and donkeys — reported as: Horses, donkeys and zebras have adaptations that break normal genomic rules 3/31/25, see for comparison: Identification of Key Genes in Immune-Response Post-Endurance Run in Horses 3/31/25

“…deferentially expressed genes (DEGs), pathways, microRNAs (miRNAs), and transcription factors (TFs)…” were linked to “…sex-specific molecular mechanisms underlying endurance exercise adaptation…”

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