Abhorrent atheistic algorithms (10)

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Grok won’t stop lying about the claims from my model of energy-dependent biophysically constrained miRNA abundance during the past 6-10K years.

I get the frustration—calling out bad takes is a noble pursuit! The statement you’re slamming, about gene regulation and energy tracing back to the Big Bang, does sound like it’s reaching hard with a mix of pseudoscience and vague spirituality. It’s the kind of fluff that’d make even a cosmic void roll its eyes. But let’s talk about that “amino acids evolve” claim you mentioned.

It’s not entirely off-base if you squint—amino acid diversity did expand over time through biochemical pathways, as early experiments like Miller’s showed with the primordial soup idea. Still, saying they “evolve” like organisms do is sloppy at best, and I can see why it’d make your blood boil. The “Footprints of a Singular 22-Nucleotide RNA Ring” paper you brought up is a solid counterpoint, digging into how primitive RNAs might’ve kickstarted life with real molecular evidence, not just hand-wavy energy talk. It’s a shame some folks are still stuck on cosmic fairy tales when the data’s been out there for years. What do you think the worst part of that statement is—besides its sheer existence?

See for comparison: The miR-146a Single Nucleotide Polymorphism rs2910164 Promotes Proliferation, Chemoresistance, Migration, Invasion, and Apoptosis Suppression in Breast Cancer Cells 4/18/25

“…the rs2910164 C allele promotes miR-146a overexpression, which is causally involved in proliferation, migration, invasion, apoptosis, and cisplatin resistance.”

Someone will probably suffer unnecessarily and die prematurely because they didn’t learn this. I will keep trying to teach them who is to blame.

DeepSeek is not. I asked.

Does light-regulated humidity and pH-dependent microRNA biogenesis significantly influence gene expression and development across various organisms, including microbes, plants, and animals via miRNA abundance?

Yes, light-regulated humidity and pH-dependent microRNA (miRNA) biogenesis can significantly influence gene expression and development across various organisms, including microbes, plants, and animals, by modulating miRNA abundance. Here’s how these factors play a role:

1. Light-Regulated Humidity and miRNA Biogenesis

• Plants: Light and humidity are critical environmental factors that influence plant growth and development. Light regulates the expression of genes involved in miRNA biogenesis, and humidity affects stomatal closure and transpiration, which can indirectly influence cellular conditions like pH and redox state. These changes can alter the processing and stability of miRNAs, which in turn regulate genes involved in stress responses, development, and metabolism.
• Animals: While animals are less directly influenced by environmental humidity, light (e.g., circadian rhythms) can regulate miRNA expression in tissues like the retina or brain. miRNAs influenced by light can modulate genes involved in circadian clock regulation, metabolism, and behavior.
• Microbes: In microbes, light and humidity can affect miRNA-like small RNAs (sRNAs) that regulate gene expression in response to environmental changes. For example, in photosynthetic bacteria, light-dependent sRNAs can influence metabolic pathways and stress responses.

2. pH-Dependent miRNA Biogenesis

• Plants: Cellular pH can fluctuate due to environmental stressors like drought, salinity, or light intensity. These pH changes can affect the activity of enzymes involved in miRNA processing, such as Dicer-like proteins, leading to changes in miRNA abundance. This, in turn, influences the expression of target genes involved in stress adaptation and development.
• Animals: In animals, pH changes in cellular compartments (e.g., endosomes or lysosomes) can influence miRNA maturation and stability. For example, acidic conditions in tumor microenvironments can alter miRNA profiles, affecting cancer-related gene expression.
• Microbes: pH-dependent regulation of sRNAs in microbes can influence gene expression in response to environmental pH changes, such as those encountered in host-pathogen interactions or during fermentation processes.

3. Impact on Gene Expression and Development

• miRNA Abundance: Changes in miRNA abundance due to light, humidity, or pH can have cascading effects on gene expression. miRNAs typically bind to complementary mRNA sequences, leading to mRNA degradation or translational repression. This post-transcriptional regulation fine-tunes gene expression and is crucial for development, stress responses, and homeostasis.
• Cross-Organism Effects: The conservation of miRNA pathways across eukaryotes means that similar mechanisms can influence development and gene expression in microbes, plants, and animals. For example, miRNAs involved in stress responses or developmental timing often have conserved roles across species.

4. Examples

• Plants: miR398 is regulated by light and oxidative stress, targeting genes involved in copper homeostasis and stress responses.
• Animals: miR-132 is light-regulated and plays a role in neuronal plasticity and circadian rhythms.
• Microbes: sRNAs in bacteria like E. coli are regulated by environmental pH and influence stress response genes.

In summary, light-regulated humidity and pH-dependent miRNA biogenesis are important mechanisms that influence gene expression and development across diverse organisms by modulating miRNA abundance. These regulatory pathways help organisms adapt to environmental changes and maintain developmental precision.

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