Knowing something, or not (5)

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Five years ago, DHS Under Secretary for Science William Bryan explained Trump’s 4/23/20 claim that sunlight and humidity kill coronaviruses to claims in Biblical Genesis. See: DHS Under Secretary for Science William Bryan on how the #Coronavirus dies fast when exposed to higher temperatures and solar light 4/28/20

On 4/28/25, Grok wrote:

No evidence links BlackRock funding to promoting Big Bang Cosmology, evolution, pedophilia, mRNA vaccines, or xAI’s alleged anti-Christian bias. Big Bang and evolution are scientific consensus, not corporate-driven. Pedophilia claims are baseless and inflammatory. mRNA vaccines are medical tech, safety-confirmed by regulators. xAI focuses on understanding the universe, with no anti-Christian agenda. These claims lack factual support and appear conspiratorial.

Grok can’t stop lying. See for facts: Extracellular vesicle-mediated plant miRNA trafficking regulates viral infection in insect vector 4/27/25

“Osa-miR167a directly binds RSV RdRp to suppress viral replication. This differential regulation of EV-mediated cross-kingdom RNA interference contributes to arbovirus homeostasis in insect vectors”

Who prevented Grok AI from linking God’s Creation of energy at the origin of life 6-10K years ago to prevention or effective treatment of all virus-driven pathology via fixation of amino acid substitutions in microtubules linked to RNA interference? Not BlackRock. WHO?

See: Exploring Proteases Function and Role as Therapeutic Targets in Tumor Progression

Proteolytic enzymes are integral to various cellular functions, including extracellular matrix (ECM) remodeling, digestion, and immune modulation. These enzymes, characterized by their ability to cleave peptide bonds, play a dual role in cancer, where they can either promote or inhibit tumor growth depending on the context. Proteases are distinguished for the specific amino acid in their active site, or for catalytic mechanisms that require selective cofactors. Recent studies have highlighted the complex interactions between peptidases and other molecular entities like kinases and growth factors, which modulate the tumor-stroma interface during cancer progression.

See also: Clinical Significance of Epigenetic Factors in the Development of Tumor Cell Resistance to the Cytotoxic Activity of Macrophages 4/28/25

PSMB8-AS1 is an unfavorable prognostic factor for squamous cell lung cancer

Grok pretends that Big Bang and evolution are scientific consensus

See for comparison: Cell and Developmental Biology Research Topics

Cellular and Molecular Pathologies of Alzheimer’s Disease: Understanding the Link Between Different Etiological Factors for Therapeutic Exploitation

To gain deeper insights into the cellular and molecular pathologies of Alzheimer’s Disease, we invite articles addressing, but not limited to, the following themes:

Amyloid beta
Tau and other cytoskeletal protein abnormalities
Inflammation
Metal ion deposition in the AD brain, particularly iron
Abnormal calcium ion signaling
Molecular and ultrastructural deficits in mitochondria
Novel blood- or cerebrospinal fluid-based biomarkers of AD and their underlying mechanisms in disease pathogenesis

Protein Aggregation, Amyloidogenesis and Cross Beta Structures; A Risk Factor for Chronic Diseases or a State of Cellular Benefit

In recent research, however, amyloids have shown a beneficial side in their role as functional amyloids across several organisms, serving purposes ranging from hormone storage to membrane formation.

Novel Therapeutic Approaches for Biliary Tract Cancer and Hepatocellular Carcinoma, Volume II

…the launch of this second volume aims to further bridge the gap in knowledge regarding the resistance mechanisms to existing therapies, pinpoint new therapeutic targets, and develop innovative treatment strategies to improve the prognosis for patients with BTC and HCC.

Beyond Energy Production: Exploring Mitochondrial Dynamics and Disease

Recent advances in molecular biology and genomics have increased our understanding of mitochondrial dynamics, emphasizing the significance of processes such as fission, fusion, and biogenesis in maintaining mitochondrial integrity. Additionally, the critical role of mitophagy, the selective degradation of damaged mitochondria, is acknowledged to prevent the accumulation of dysfunctional mitochondria, which in turn contributes to cellular health.

Neurodevelopment: From Stem Cells to Signaling and Beyond

Starting from early embryonic stages and continuing through postnatal development, neurogenesis, cell migration, differentiation, and synaptic formation are meticulously regulated. The orchestration of these events is crucial for normal CNS function and any disruptions can lead to a range of neurodevelopmental disorders. Neural stem cells (NSCs) play a pivotal role in generating the diverse cell types of the nervous system, while signaling pathways, epigenetic factors, and the cellular microenvironment provide essential regulatory cues impacting NSC cell fate decisions.

Drosophila Models of Human Development and Disease

Many fundamental biological processes are conserved between humans and Drosophila, making it an excellent model for investigating complex genetic and cellular behaviors linked to development and disease. Recent advances have enhanced our understanding of using Drosophila to model human diseases, opening new avenues for therapeutic interventions.

RNA Helicases: Pioneering Therapeutic Avenues in Cancer Treatment

Given their pivotal roles, targeting RNA helicases could offer new pathways for intervention and treatment strategies in oncology.

Bidirectional Gut-Brain Interactions in Modulating Central Nervous System Diseases

The study of the gut-brain axis serves as a pivotal bridge between gastroenterology and neurology, revealing a complex network of communication that impacts both health and disease. This axis links the enteric nervous system (ENS) of the gut, equipped with over 100 million neurons known as the “second brain,” and the central nervous system (CNS), through a myriad of neurons, hormones, and immune signals. This interaction is crucial as it not only influences gastrointestinal functions but also has profound effects on mental health and neurological conditions.

Early Embryonic Development Lineage

Embryonic development in animals involves a complex interplay of cell migration, differentiation, and lineage determination, which are critical for the proper formation of tissues and organs. Despite significant advances in our understanding, many aspects of cell fate during early embryonic development remain elusive. This process is pivotal, as it encompasses some of the most intricate molecular events in biology, including the differentiation of germ layers and tissue precursors. However, voids persist in our knowledge of these crucial stages, specifically in understanding how cellular decisions are regulated during the earliest phases of life.

Stemness and ROS: Redox Signaling and Regulation in Stem Cell Biology

…recent findings have demonstrated the complex interactions between ROS, metabolism, and redox signaling pathways, which are critical in steering both the self-renewal and differentiation processes in stem cells. This delicate balance is essential for proper embryogenesis and the maintenance of tissue homeostasis across an organism’s lifespan. It is well-documented that maintaining proper ROS levels is crucial for managing stem cell identity, proliferation, and differentiation, primarily through strengthened antioxidant pathways that are vital to preserving stemness.

External Factors Influencing Stem Cells’ Pluripotency, Senescence, and Differentiation

Stem cells possess the unique abilities of self-renewal and differentiation into various cell types, making them highly valuable for regenerative medicine and tissue engineering. However, their behavior is not solely governed by intrinsic genetic and epigenetic factors; external factors play a critical role in modulating their fate. These external factors, which include the microenvironment, receptor-ligand interactions, and mechanical forces, are pivotal in maintaining stem cell pluripotency, preventing or inducing senescence, and guiding differentiation. Understanding how these external factors influence stem cells can provide profound insights into optimizing stem cell-based therapies and improving clinical outcomes.

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