miRNA-mediated autophagy (1)

By: James V. Kohl | Published on: May 3, 2025

AI Overview:

Autophagy is a cellular process where damaged or unnecessary cellular components are removed and recycled. It’s a natural self-degradative mechanism that helps maintain cellular health and can be activated by fasting or calorie restriction. 

Autophagy is energy-dependent and miRNA-mediated via miRNA abundance. See: miRNAs 183,933 results

Food energy-dependent autophagy has been known to occur across kingdoms during the past 6-10K years. See this 6/27/20 post to Twitter (X)

Past 5,000 years prolific for changes to human genome 11/28/12

“The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.”

The pheromone regulated physiology of reproduction links miRNA abundance and autophagy to all biodiversity via the overwhelming complexity of God’s ATP-dependent Creation of RNA at the origin of life.

For instance, see:

The Influence of Host miRNA Binding to RNA Within RNA Viruses on Virus Multiplication 4/21/22

An essential role for Cmtr2 in mammalian embryonic development 7/31/24

5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming 10/17/24

Therapeutic application of extracellular vesicles in human diseases 4/3/25

Identification of Senomorphic miRNAs in Embryonic Progenitor and Adult Stem Cell-Derived Extracellular Vesicles 4/24/25

In vivo AGO-APP identifies a module of microRNAs cooperatively preserving neural progenitors 4/29/25

N 6-methyladenosine modifications stabilize phosphate starvation response–related mRNAs in plant adaptation to nutrient-deficient stress 5/1/25

Non-conserved microRNAs and their roles in plants: the case for legumes 5/1/25

Leaf miRNAs of Withania somnifera Negatively Regulate the Aging-Associated Genes in C. elegans 5/2/25

Circular RNAs modulate cell death in cardiovascular diseases 5/2/25

and

A unifying model for microRNA-guided silencing of messenger RNAs 4/22/25 indexed 5/2/25

Link energy-dependent miRNA abundance to healthy longevity across kingdoms via RNA interference (mRNA silencing) and fixation of amino acid substitutions in microtubules.

See: Disrupting Cancer 12/5/14 (with microtubule inhibition) and Medical Doctor Exposes the Real Reason Why Ivermectin Was Banned 7/31/24

The effectiveness of Abraxane and Ivermectin were built from the scientific truth about energy-dependent microtubule inhibitors.

See also: The 𝕏 recommendation algorithm is being replaced with a lightweight version of @Grok, so will soon be dramatically better!

You should notice some improvement already.

Improvement will come @Grok when it abandons outdated claims that mainstream science incorporates moronic theories. The moronic theories link the automagical emergence of energy from the cosmic void to the mathemagical evolution of people from pond scum.

“…a lightweight version of @Grok…” will be better if it eliminates claims made by moronic theorists who failed to address the energy-dependent facts about autophagy. Intelligent serious scientists will continue to address the is a critical need to link autophagy to biodiversity, and that will determine the future of stupid bots.


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