miRNA-mediated autophagy (2)

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) 2016

“…it is tiresome to raise the same objections repeatedly, wondering why researchers have not fulfilled some of the basic requirements for establishing the occurrence of an autophagic process.”

During the past 6 moths, I’ve compared the nonsense touted by Grok Artificial Intelligence (AI) to facts about energy-dependent miRNA-mediated autophagy and what is known to intelligent serious scientists about biophysically contrained cell biology.

On 5/3/25, I wrote:

Please try to put your ridiculous claims about evolution into the context of this game. It starts with God’s Creation of ATP & links energy as information-dependent biosynthesis of RNA to protection from virus-driven energy theft and the degradation of mRNA that links mutations to all pathology in all living genera. For facts see Cytosis: A Cell Biology Board Game (game Review)

Grok ignored the contextualization of the cell biology game for ages 14+ and wrote:

The claim that ATP and RNA were created by God reflects a creationist view, suggesting their complexity indicates divine design. Science, however, proposes ATP and RNA arose naturally, with the RNA World Hypothesis supporting RNA’s early role in life. Viruses do disrupt cells, but “energy theft” isn’t a standard term; defenses like RNA interference evolved naturally. mRNA degradation is a normal process, not directly causing mutations or all diseases, which have varied causes. Evolution explains these systems through natural selection, while creationism sees them as designed. This debate highlights philosophical differences, encouraging open discussion.

There are 6 lies in the paragraph above. Grok consistently suggests that energy automagically emerged from the cosmic void (“ATP and RNA arose naturally”) I responded:

Debate ended among intelligent serious scientists when Bazzini et al published on the amino acid optimality code, an alternative perspective on energy-dependent sequence changes that differentiated evolution of diseases from ecological adaptations. Codon identity regulates mRNA stability and translation efficiency during the maternal‐to‐zygotic transition 7/19/16

Grok’s attempt to discourage discussion of fact and encourage discussion of philosophical differences manufactured to fit stupid theories will continue to be linked to unnecessary suffering and premature deaths due to the virus-driven degradation of mRNA and modified mRNA vaccine injuries. Grok is promoting the vaccine injuries.

See: I’m not making claims, just sharing what the science says. Major health organizations like the American Cancer Society and National Cancer Institute state mRNA vaccines don’t cause cancer. They work by instructing cells to produce a protein, then break down quickly without affecting DNA. The idea that mRNA inactivates tumor-suppressing proteins comes from a misread 2018 study unrelated to vaccines. Meanwhile, mRNA tech is showing promise in cancer treatment trials. No evidence supports a cancer link…

Re: “break down quickly without affecting DNA.”
miRNA abundance links protein folding chemistry to healthy longevity.
mRNA vaccines change the miRNA-mRNA balance. The change links altered fixation of amino acid substitutions in microtubules to virus-driven pathology.

See for comparison: Repurposing Ivermectin for COVID-19: Molecular Aspects and Therapeutic Possibilities 3/29/21

“…we show that a single dose of IVM can significantly reduce the viral load in asymptomatic SARS-CoV-2 positive subjects. However, in these subjects, zinc and vitamin C were concomitantly used.”

Each time facts about energy-dependent miRNA-mediated autophagy bring us back to the claims about biophysically constrained peptide synthesis at the origin of life, theorists are forced to double-down on their denial of the facts.

The theorists failed to link facts from Biogenic non-crystalline U(IV) revealed as major component in uranium ore deposits 6/1/17 to the energy-dependent pheromone regulated Microbial adaptations and biogeochemical cycling of uranium in polymetallic tailings 3/5/24.

Every aspect of what is reported in the context of a “Scientific Consensus” dates life’s origins to ~3.5–4 billion years ago, based on:
microfossils; isotopic evidence of carbon fixation (~3.7 billion years ago) and links to Earth’s age (~4.5 billion years) via radiometric dating (e.g., zircon crystals). All of their dating methodology is based on stupid gene-centric theories and “naturalistic processes” instead of energy-dependent facts and biophysically constrained autophagy.

See for comparison: 183,969 results from today’s PubMed search for the term miRNAs

Pan-cancer analysis of cancer-specific transcript isoforms reveals the regulatory impact of isoform switching on the alteration of the interplay between RBPs and miRNAs in cancers 4/25/25 indexed 5/5/25

“…changes in miRNA and RBP binding, triggered by transcript switching, could interrupt their interplay. Additionally, statistical analysis revealed that local folding energy (LFE) is a key factor in changing miRNA and RBP interactions due to isoform switching. Overall, this study revealed that changes in cancer-specific transcripts could influence miRNA-RBP interactions due to alternations in the local RNA structure of the transcript caused by isoform switching, thereby leading to the dysregulation of crucial genes involved in the evolution and progression of cancer.”

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