miRNA-mediated autophagy (4)

By: James V. Kohl | Published on: May 7, 2025

5/6/25
Kohl’s post highlights an alternative model where energy-dependent miRNA processes, interpreted through a Biblical lens, explain life’s diversity. While miRNAs and energy are undeniably important, the scientific consensus attributes biodiversity to evolutionary processes involving multiple mechanisms, not a singular energy-driven system. I’ve corrected my earlier error on whale evolution and aim to engage more constructively with Kohl’s ideas, focusing on the evidence while acknowledging differing perspectives on life’s origins.

See also: Study Reveals Quantum Forces Shape Proton Transfer in Living Systems 5/6/25

“Traditionally, scientists believed that protons in living systems traveled through a hopping mechanism between water molecules and amino acids. But this model ignored the role of quantum spin….”

That level of ignorance was contextualized in Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20.

Theorists linked the automagical emergence of energy from the cosmic void to the mathemagical evolution of people from pond scum. Grok AI realized that was a mistake to ignore energy-dependent miRNA-mediated quantum coherence and coherently organized biology but prefers to keep theories linked to billions and millions of years of natural selection of beneficial mutations and evolved biodiversity.

Intelligent serious scientists know that every aspect of biophysically constrained life on Earth is energy-dependent and miRNA-mediated in the context of autophagy, a cellular process where a cell cleans itself by removing and recycling damaged or unnecessary parts, like proteins and organelles.

Viruses steal the energy. They disrupt autophagic flux and cause excessive degradation of mRNA that is linked to all pathology across kingdoms.

See:

  1. Cell–cell contact globally activates microRNA biogenesis 4/28/09
  2. Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system 2/27/15
  3. Electron diffraction and the hydrogen atom 1/13/17
  4. Light triggers the miRNA-Biogenetic Inconsistency for De-etiolated Seedling Survivability in Arabidopsis thaliana 3/2/20
  5. Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20 (reported as: Proton regulator of essential cancer microRNA 10/27/20)
  6. Direct Observation of Protonation State Modulation in SARS-CoV-2 Main Protease upon Inhibitor Binding with Neutron Crystallography 3/23/21
  7. Structural determinants in the miRNA/miRNA* duplex and the DCL1 PAZ domain for precise and efficient plant miRNA processing. 8/13/24
  8. Involvement of the miR156/SPLs/NLP7 modules in plant lateral root development and nitrogen uptake 5/5/25
  9. Coupling between electrons’ spin and proton transfer in chiral biological crystals 5/5/25
  10. Rare DCM associated variants in pre-miR-208a disrupt miRNA maturation and function 5/6/25
  11. When the heat Is on, HYL1 steps in: Regulating miRNA biogenesis for plant thermotolerance 5/6/25

Bacteria evolve over a weekend 2/26/15

Have you linked everything known to intelligent serious scientists about light-activated miRNA biogenesis at the origin of life 6-10K years ago from 1) the physiology of reproduction to autophagy and 2) the weekend resurrection of the bacterial flagellum in P. fluorescens to 3) prevention or effective treatment of all virus-driven diseases?

If not, you probably believe the “scientific consensus” reported by Grok AI to be the link from the automagical emergence of energy from the cosmic void to the mathemagical evolution of people from pond scum.


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