Fixation of hope in DNA (9)

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The VA’s “Million Veteran Program” links facts from USAF exome sequencing to prevention of all virus-driven mental and physical pathology via miR-128-3p Reduces Proliferation and Immune Escape in Acute Myeloid Leukemia Through Targeted Regulation of ZEB1 5/17/25

AI Overview:

“ZEB1 (Zinc Finger E-Box Binding Homeobox 1) is a transcription factor that plays a crucial role in regulating gene expression, particularly in relation to cancer and embryonic development. It is known for its involvement in epithelial-mesenchymal transition (EMT), a process where epithelial cells acquire mesenchymal characteristics. ZEB1 is often associated with tumor progression, invasiveness, and metastasis, and its expression can be linked to poor prognosis in various cancers.” 

For comparison, see [Grok] “can’t scientifically validate a Genesis-based timeline.” linked from energy-dependent miRNA abundance to prevention of virus-driven pathology via the physiology of reproduction across kingdoms.

Thank God, there is no need for Grok to validate the Genesis-based timeline. All intelligent serious scientists have done it via 184,436 publications that mention miRNAs.

For a recent example linked to cancer prevention, see: The regulation of LRPs by miRNAs in cancer: influencing cancer characteristics and responses to treatment 5/17/25

“LRPs [lipoprotein receptor-related proteins] are involved in the regulation of many key oncogenes, and they also act as target genes for a range of microRNAs. Here, we have elaborated the role of miRNA in regulating LRP and its downstream genes in the pathogenesis of various human malignancies (Table 1). Progress in miRNA/LRP research in human oncology holds the promise of elucidating the intricate molecular controls of cancer, potentially pointing the way for novel avenues in cancer management and therapeutics.”

For a recent example linked to biophysical constraints on coronavirus replication, see also: The micro-RNA expression profile predicts the severity of SARS-CoV-2 infection 5/17/25

“MiR181a-5p was demonstrated to mediate the inflammatory response in sepsis and is significantly upregulated in RAW 264.7 macrophages after lipopolysaccharide stimulation²⁶.”

Grok AI cited the automagical and mathemagical: “….energy expansions of evolution” 4/28/17

It was published after my 2/15/17 presentation on “Energy as information and constrained endogenous RNA interference”

I believe that only a stupid deep-state funded bot would continue to present its ideologically biased anti-religion perspective after Pope Leo and President Trump aligned themselves against AI as a existential threat to humility and to humanity.

However, when I see reports like this linked to modified mRNA-induced cancer, I sometimes lose hope:

Suppression of breast cancer metastatic behavior by microRNAs targeting EMT transcription factors. A relevant participation of miR-196a-5p and miR-22-3p in ZEB1 expression 5/18/25

“microRNAs selected in this work can regulate gene expression trough 3’UTR region of EMT-transcription factors. In BC cells, miR-196a-5p and miR-22-3p decrease ZEB1 levels, being novel modulators of EMT. Also, the eight evaluated microRNAs, reduced the metastatic hallmarks in BC cells.”

Will Targeted Regulation of ZEB1 5/17/25 be linked to Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene 9/2/11 via Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20?

See also: Molecular Biology of the Cell. 4th edition. The RNA World and the Origins of Life (2002)

Protein Folding Thermodynamics and Dynamics: Where Physics, Chemistry and Biology Meet 8/31/09

The authors

“…postulated that proteins have also a special conformation-native state – and that each amino acid can be either in its native conformation or in any of ν non-native ones.”

That claim is consistent with the claims from The interface of protein structure, protein biophysics, and molecular evolution 4/23/12

See also: Energy, genes and evolution: introduction to an evolutionary synthesis 7/19/13

Rather than admit to the facts from Epigenetic effects of stress by Bruce McEwen (1) 7/12/17, it seems likely that Grok will continue to ignore my claims about light-activated miRNA abundance and viral latency across kingdoms.

Even when Grok cites the references that are related to my works, it does not seem capable of integrating the facts that link God’s Creation of energy at the origin of life to claims from McEwen et al., (1964), which link the ATP-dependent Creation of RNA from miRNA abundance to all biodiversity on Earth via what intelligent serious scientists have learned about Thermal stress, p53 structures and learning from elephants 8/7/24

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