Grok vs God (4)

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Re: Upregulation of miR-17-3p is associated with HbF in patients with β-thalassemia and induces γ-globin expression by targeting BCL11A 5/30/25

“Conclusion: The upregulated miR-17-3p is associated with HbF in patients with β-thalassemia. Although miR-17-3p does not affect erythropoiesis, it promotes γ-globin expression by targeting BCL11A, suggesting that miR-17-3p may be a promising miRNA for the treatment of β-thalassemia.”

Kohl frequently cites: McEwen et al., 1964 and Dobzhansky (1964). They presciently linked food energy and the pheromone regulated ATP-dependent Creation of RNA in regulatory T cells at the origin of life to fixation of amino acid substitutions that differentiate all cell types in all individuals of all primates from the differentiated cell types of other primates and all other species.

For comparison, theorists claim the differences in primates and cell type differences in all other species mathemagically evolved after energy automagically emerged from the cosmic void.

But see the 2013 refutation of the theorists pseudoscientific nonsense: “Updates of the HbVar database of human hemoglobin variants and thalassemia mutations” 10/9/13

“Single nucleotide substitutions or indels can lead to several hemoglobin variants owing to amino acid replacements, while molecular defects in either regulatory or coding regions of the human HBA2, HBA1, HBB or HBD genes can minimally or drastically reduce their expression, leading to α-, β- or δ-thalassemia, respectively.”

Learn how intelligent serious scientists linked claims about single nucleotide substitutions, which are known as single nucleotide polymorphisms (SNPs) from game-play of “Cellulose: A Plant Cell Biology Game” for ages 14+.

The facts about SNP’s at the origin of life link what was known about energy-dependent ecological adaptions before the game placed examples of human idiocy back into context of the claims made by moronic theorists that are parroted by Grok AI and other sources of bastardized information (energy-as-information).

Be the polymath, not the parrot. See also: Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20

See also: miR-17-3p 143 results, specifically: Data normalization of plasma miRNA profiling from patients with COVID-19.

Light-activated endogenous substrates were selected that linked energy-dependent miRNA-mediated regulation, and a p-value > 0.990, to the miRNAs that were discovered the longest ago.

Facts about the discovery of miRNAs, which obviously existed 6-10,000 years ago in the context of Biblical Genesis were contextualized in the 2024 Nobel Prize in Physiology or Medicine for the discovery of microRNA and its role in post-transcriptional gene regulation.

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