pH-sensitive nanomedicine (3)

By: James V. Kohl | Published on: June 18, 2025

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Pan-viral ORFs discovery using massively parallel ribosome profiling 6/13/25 links artificial intelligence (aka human idiocy) to light-activated carbon fixation in cyanobacteria via nutrient-dependent pheromone regulated fixation of one amino acid, EDAR V370A in populations of mice and humans.

Fixation of amino acid substitutions in microtubules links protection from the virus-driven degradation of mRNA to the effective treatment for cancer.

For example: Identifying Recent Adaptations in Large-Scale Genomic Data 2/14/13 with co-author Eric S. Lander (Biden’s former science advisor), and East Asian Physical Traits Linked to 35,000-Year-Old Mutation 2/14/13.

In this 2012 representation of facts from Mendel’s works with peas and Darwin’s claims about “conditions of life,” Eric Lander makes his position on protection from viruses perfectly clear: NOVA scienceNOW : 8 – RNAi 7/23/12

“RNA, the close chemical cousin of DNA, was once thought to be a bit player in the life of a cell, but not anymore. RNA is now at the heart of a scientific and medical revolution. It’s a revolution that started with the cultivation of a purple petunia, and it has led scientists to what may be the most important advance in biology in decades. Through a process known as RNAi (the “i” is for interference), researchers have a new way to shut off specific genes, yielding insights into the human genome as well as providing potential treatments for a wide range of diseases.”

Diseases have been linked to gene-centric claims about a 35,000-year-old mutation were linked to thicker hair shafts, more sweat glands, characteristically identified teeth, smaller breasts and the claim that “Each race has a different set of selected regions.”

This suggests the ignorance of RNA interference (RNAi) caused the invention of gene-centric moronic theories that contributed to racism and to sexism.

See also: Another Dingbat Sexual Selection Theory 2/22/13

“Beware of evolutionary explanations that rest on what men find attractive.”

“the sexually visible effects of EDAR are likely to have been stronger drivers of natural selection than sweat glands.”

The APA Apology to People of Color for APA’s Role in Promoting, Perpetuating, and Failing to Challenge Racism, Racial Discrimination, and Human Hierarchy in U.S. 10/29/21 predicted that Grok would challenge facts that link food energy-dependent pheromone regulated sexual differentiation in yeasts to natural selection across species via the mouse to human model of EDAR V370A (one single nucleotide polymorphism) and fixation of one amino acid substitution that was linked to survival of our species via the mouse model organism.

“Single nucleotide substitutions or indels [INsertions/DELetionS] can lead to several hemoglobin variants owing to amino acid replacements, while molecular defects in either regulatory or coding regions of the human HBA2, HBA1, HBB or HBD genes can minimally or drastically reduce their expression, leading to α-, β- or δ-thalassemia, respectively.”

See also the video representation: 2 Cell Studies Reveal Genetic Variation Driving Human Evolution 2/14/13, and the links from differences in amino acid substitutions to hemoglobin variants and protection from virus-driven diseases in Cancer Decoded 6/17/25 “a groundbreaking new video program dedicated to exploring and redefining how the world talks about cancer, while fostering connections through honest conversations…”

“Cancer Decoded” promotes claims that lymphocytes evolved during 450 millions years. However, the link to effective albumin-based treatment of glyphosate-induced glioblastoma in Vietnam veterans was predicted in Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene 9/2/11.

Ignoring all that led Patrick Soon-Shiong to miss the fact that the effectiveness of Abraxane is linked to an albumin-bound microtubule inhibitor that promotes the assembly of microtubules. This stabilizes tubulin dimers by preventing their depolymerization.

By interfering with microtubule function, Dr. Patrick Soon-Shiong’s invention of Abraxane inhibits the ability of cancer cells to divide and multiply, ultimately leading to their death.

For comparison to facts about the potential of hydrogen and pH-sensitive nanomedicine via use of microtubule inhibitors (and protease inhibitors), Grok AI wrote:

Microtubules aid viral replication, with some studies suggesting a defensive role when disrupted. Substitutions may alter microtubule function, yet no research directly links them to resisting viral mutations. The claim needs more study to be substantiated.