First biomarker evidence of DDT-autism link …they point to androgen receptor binding, a process key to neurodevelopment. A study in rats found DDE inhibits androgen receptor binding, an outcome also seen in a rat model of autism. These chemicals are transferred across the placenta in concentrations greater than those seen in the mother’s blood. “Unfortunately, … MicroRNA-mediated DDT-autism link
Perception of social interaction compresses subjective duration in an oxytocin-dependent manner “…perceived time, rather than being a faithful representation of physical time, is highly idiosyncratic and ingrained with one’s personality trait. Moreover, they suggest that oxytocin is involved in mediating time perception of social interaction, further supporting the role of oxytocin in human social cognition.” … The Social Brain of Autism
Mosaic Epigenetic Dysregulation of Ectodermal Cells in Autism Spectrum Disorder clearly links the de novo creation of olfactory receptor gene OR2L13, from decreased nutrient-dependent DNA methylation to sensory processing in ASD’s. A series of published works I posted yesterday in Ecological variation leads to ecological adaptations links failed adaptations manifested in autism spectrum disorders (ASDs) via the sensing … From odors to autism spectrum disorder
Schizophrenia’s Intricacies By Abby Olena Two studies provide insight into the genetics of the disorder and show again how complex it is. Excerpt: “Even small new mutations were not randomly occurring, but were concentrated in a relatively small number of genes that are crucial to the way nerve cells communicate across synapses.” My comment: Predictably, someone … One straightforward hypothesis: Schizophrenia and autism
Two articles appeared on the same day in the psychiatry research yahoo group cue that link the sense of smell to atypical development via the ectoderm and neuronal “wiring” of the brain and atypical behavior in autism. Food odor-associated atypical behavior: 1) “What happens when a child with autism refuses most foods?.” November 8th, 2013. … Odors, the ectoderm, brain development, and autism
Functional connectivity in the first year of life in infants at-risk for autism: a preliminary near-infrared spectroscopy study Brandon Keehn, Jennifer Wagner, Helen Tager-Flusberg, and Charles A Nelson Excerpt: Although we are currently unable to determine whether differences in [increased] connectivity at 3- and [statistically insignificant reduced connectivity at] 12-months were driven by infants that … Nutrient-dependent pheromone-controlled autism spectrum disorders
Body Odors Promote Automatic Imitation in Autism Abstract Excerpt: “The maternal odor, which conveys a social message otherwise neglected, helps autistic children to covertly imitate the actions of others. Our results represent a starting point holding theoretical and practical relevance for the development of new strategies to enhance communication and social behavior among autistic individuals.” … Autism: a social message in maternal odor
Science 18 January 2013: Vol. 339 no. 6117 pp. 267-269 DOI: 10.1126/science.339.6117.267 The Promise and Perils of Oxytocin by Greg Miller [subscription required] Is oxytocin the next revolution in psychiatric medicine—or an overhyped hormone that could make some patients worse? Excerpt 1: “One of the real deficits in psychiatry research is a complete lack of … Playing with oxytocin, autism, and wolves
Genetic Test Predicts Autism Risk With High Degree of Accuracy Pam Harrison September 19, 2012 Excerpt: …”what is consistent and what we show in our study are the signalling pathways, and this indicates that the same systems (glutamatergic and innate immunity) are probably important to understanding the disorder…” Predicting the diagnosis of autism spectrum disorder using … Genetic test predicts autism risk
The epigenetic effects are on interactions among all the other neuronal systems and hormone secretion that interact with the GnRH neuronal system, which is central to all developmental differences in the brain of males and females.
