ALPHA GENOMIX
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Alpha genomics (for those unfamiliar with their spelling)
Re: On this team, Dr. Hani El Shawa, is also first author of Prenatal Ethanol Exposure Disrupts Intraneocortical Circuitry, Cortical Gene Expression, and Behavior in a Mouse Model of FASD. The Journal of Neuroscience, 27 November 2013, 33(48): 18893-18905.
Excerpt: “Changes in gene expression reported in this study may be caused by altered DNA methylation, an epigenetic modification that cells use to mediate gene expression (Moore et al., 2013), cell differentiation, and embryonic development (Monk et al., 1987; Feng and Fan, 2009). Methylation occurs at the fifth position of cytosine and is driven by three conserved enzymes, DNA methyltransferase 1 (DNMT1), DNMT3A, and DNMT3B, which together are responsible for its deposition and maintenance, a function required for normal development (Li et al., 1992; Okano et al., 1999). Methyltransferase activity can be modified by exposure to ethanol; chronic exposure to ethanol is associated with reduced DNMT3B mRNA expression and hypermethylation in adults (Bönsch et al., 2006). Embryonic exposure to ethanol has been shown to alter DNA methylation patterns at neurulation, with increased methylation of genes on chromosome 10 and X correlating with an increase in neural tube defects (Liu et al., 2009). Furthermore, ethanol exposure impacts methyl donors (Mason and Choi, 2005), highlighting a possible mechanism by which ethanol, through methylation, can drive downstream epigenetic modifications and alter gene expression, as we have seen in this study (Haycock, 2009).”
My comment: The article establishes his extraordinary understanding of biologically-based cause and effect. He has already integrated current information from across the disciplines of physics, chemistry, and molecular biology and made a cohesive representation that differentiates healthy embryonic development from the pathology associated with ethanol uptake during pregnancy. The clear link is from epigenetic effects of chemicals on gene activation to affects on behavioral development via DNA methylation
Similarly, Jennifer Doudna’s works with others led to detailed aspects of RNA-directed DNA methylation and cell type differentiation that show up in the 2014 Nobel Prize in Physiology or Medicine. It was awarded to John O’Keefe, 75, a British-American scientist, who will share the prize of $1.1 million with May-Britt Moser, 51, and Edvard I. Moser, 52, for their works. They detailed how the experience-dependent development of different cell types involved in learning and memory can be linked to humans from model organisms like the honeybee. See: Epigenomics and the concept of degeneracy in biological systems
Jennifer Doudna is already well on her way to winning a Nobel Prize for her works. See for examples: 1) DNA interrogation by the CRISPR RNA-guided endonuclease Cas9 and 2) Programmable RNA recognition and cleavage by CRISPR/Cas9
Conclusion from 2): “The ability to recognize endogenous RNAs within complex mixtures with high affinity and in a programmable manner paves the way for direct transcript detection, analysis and manipulation without the need for genetically encoded affinity tags.”
That ability to recognize endogenous RNAs within complex mixtures shows up in Alpha Genomix testing, which represents a quantum leap forward from what many experts inaccurately attribute to mutations, natural selection, and evolution. Instead, Alpha Genomix is leading the way by incorporating what is currently known about RNA-directed DNA methylation and RNA-mediated events that link enzymes to amino acid substitutions that differentiate cell types.
The RNA-mediated amino acid substitutions differentiate all cell types of all individuals of all species. Testing to determine the differences in enzymes and other factors that alter cell types enables predictions to be made about how an individual may respond to specific medications based on their unique genotype and its phenotypic expression at the level of cellular metabolism.
At the level of differences in cell type metabolism, RNA-mediated events occur outside the context of ridiculous misrepresentations made by evolutionary theorists and evolutionary theists who have never described a biologically-based evolutionary event. They still think in terms of genetically-determined cause and effect as if their theories had any explanatory power in the context of what’s been learned about cell type differentiation since 1973, when Dobzhansky wrote: “…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.”
Until then, the theorists and evolutionary theists were stuck trying to explain how ecologically adapted organisms somehow evolved over hundreds of millions of years, despite clear indications that ecological variation in nutrient availability leads to the metabolism of the nutrients via receptor-mediated events and enzymes, which link the metabolism of nutrients to species-specific pheromones that control the physiology of reproduction. The result is the species specificity of morphological and behavioral phenotypes that clearly are ecological adaptations, not mutations that lead to perturbed protein folding, diseases, and disorders. For example, dietary differences markedly alter how much coumadin (characterized as a ‘blood thinner’) will regulate the potential for blod clot formation. Too much coumadin combined with poor diet or altered diet may lead to toxicity associated with morbidity and mortality. Beneficial effects and toxicity have been linked to amino acids.
For examples of the difference a single amino acid substitution makes in species from microbes to man see: Nutrient-dependent/pheromone-controlled adaptive evolution: a model. Note, however, that even I was stuck with use of the term evolution, since too few people recognize the difference between controlled ecological adaptations and mutation-driven evolution.
Mutation-driven evolution does not occur for reasons that should be obvious. Fixation of amino acid substitutions occurs across populations; fixation of mutations may appear to temporarily occur across some lineages for a few generations, but only the amino acids substitutions contribute to organized genomes. The idea that mutations organize genomes in different species is ridiculous. It was invented based on assumptions made more than 80 years ago.
Alpha genomix has left those assumptions behind, and other companies may also now begin to do so when the biological facts become better known than the ridiculous theory about evolution. For examples of how serious scientists like Dr. El Shawa have moved away from a ‘one size fits all’ model of health and treatment, see: Hypothalamic PGC-1α Protects Against High-Fat Diet Exposure by Regulating ERα reported as: Male and female brains aren’t equal when it comes to fat.
Excerpt: “…differences in the brain lead to greater inflammation and increased health risks in males that indulge on fatty foods in comparison to females, a new study in mice shows. Earlier data from Clegg’s team and others had suggested that inflammation in the brain is tied to overeating, blood sugar imbalances, and increased inflammation in other parts of the body, including fat tissue.” We have always had ‘one size fits all’ with respect to our nutritional information and our pharmaceutical approach,” Clegg said. “Our data begin to suggest that sex should be factored in, and men should be more closely monitored for fat intake and inflammation than women.”
My comment: My co-authors and I may have been the first to publish on RNA-mediated sex differences in cell types in species from microbes to man. In our 1996 Hormones and Behavior review article From Fertilization to Adult Sexual Behavior, we wrote: “Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.”
If not for the incessant touting of evolutionary theory — as if it had the explanatory power to link molecular epigenetics to sex differences in cell types across all species — other serious scientists would have been moving forward since 1973, instead of living in the past as also indicated by Dobzhansky 50 years ago when he wrote: “…the only worthwhile biology is molecular biology. All else is “bird watching” or “butterfly collecting.” Bird watching and butterfly collecting are occupations manifestly unworthy of serious scientists!”
Among the serious scientists who remain in the category of astute bird-watchers, but also understand molecular epigenetics, are those associated with Donna L. Maney’s group. They continue to present their findings in the context of nutrient-dependent pheromone-controlled hormone-organized and hormone-activated behaviors that are linked from sexual differentiation of cell types in yeasts via insect models of life history transitions to sex differences and individual differences in the cell types of all vertebrates. The differences in the behavioral morphs of white-throated sparrows are obviously nutrient-dependent, but the direct link from differences in feeding patterns parallels what others have reported in other models of developmental differences in morphological and behavioral phenotypes that will lead others to ask: “What about birds?”
That was the question asked when I presented my model to Jay R. Feierman in 1995. Like many other self-proclaimed experts, he refuses to accept any experimental evidence that links the birds and the bees to cell type differentiation in all cells of all tissues of all organs and all organ systems via the conserved molecular mechanisms the enable increasing organismal complexity. Instead, Feierman claims: “Random mutations are the substrates on which directional natural selection acts.” — as if any evidence of biologically-based cause and effect has ever confirmed the pseudoscientific nonsense touted by evolutionary theorists, or by human ethologists.
It is past time to leave ridiculous theories behind and enter the real world of personalized medicine heralded by Alpha Genomix.
See also: Combating Evolution to Fight Disease. Know who the enemy is and see: RNA and dynamic nuclear organization.
Ask if any member of the Society for Neuroscience and the Society for Integrative and Comparative Biology still believes in theories about mutations that lead from natural selection to the evolution of biodiversity. Dr. El Shawa is a member of both societies. If others still believe in ridiculous theories they may be among those who Denis Noble addressed when he said: “If you learnt evolutionary biology and genetics a decade or more ago you need to be aware that those debates have moved on very considerably, as has the experimental and field work on which they are based.” (p 1014) Everything currently known about biologically-based cause and effect links ecological variation to ecological adaptations.
For example: Reverse ecology describes the use of genomics to study the impact of ecological factors on the partitioning of genomic variation in one or more natural populations.
This approach can be used to link enzymes and other factors from epigenetic effects across human life histories that determine their pharmacogenomic response (i.e., their response to different prescription pharmaceuticals.) The responses are becoming more predictable based on what is known about enzymes that link nutrient-uptake and metabolism to RNA-directed DNA methylation and RNA-mediated events that alter the organized genomes of insect, like the honeybee and mammals like humans. The most recent example of biologically-based cause and effect was reported 15 October 2014 as House Fly Genome Reveals Expanded Immune System.
Excerpt 1): “The genome, roughly twice the size of the fruit fly’s genome, revealed an expanded number of immune response and defense genes. The researchers also discovered an expansion in the number of cytochrome P450s, which help the flies metabolize environmental toxins. “House flies have a lot more of these enzymes than would be expected based on other insects they are related to,” said Scott, noting that the house fly’s close relative, Glossina morsitans (tsetse fly), has half as many cytochrome P450s. These enzymes are more ancient than insecticides.”
Excerpt 2): “The M. domestica genome also revealed many genes for chemoreceptors, which detect certain chemical stimuli in the environment. These receptors are important in sensing food and moving in ways critical for survival, allowing house flies to detect a wide variety of different things, Scott said.”
Their focus is on chemoreceptors involved in taste. My focus is on chemoreceptors that link food odors to the de novo creation of olfactory receptors that link nutrient uptake to cell type differences in all cells of all individuals of all species via the conserved molecular mechanisms that show up in the testing provided by Alpha Genomics. Their results attest to the unique features of each individual’s metabolism and will help medical practitioners know how to personalize your treatment and avoid some of the hazards associated with medications, like coumadin toxicity.
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Polymaths and paradigm shifts: from Asimov to Bear (4)
6 MIN READ
0
Polymaths and paradigm shifts: from Asimov to Bear (3)
3 MIN READ
0
Polymaths and paradigm shifts: from Asimov to Bear (2)
4 MIN READ
0
How to create biologically uninformed theorists
7 MIN READ
0
From photons to the proton motive force (2)
3 MIN READ
0
Ecological adaptation: A new definition of heredity (3)
4 MIN READ
0
Creating biophysically constrained viral latency (2)
2 MIN READ
0
George Church refutes theistic evolution (4)
4 MIN READ
0
Conceptual critique: Innateness vs the death gene (2)
5 MIN READ
0
How to biophysically constrain the flu virus (1)
4 MIN READ
0
Subatomic: From thermophiles to humans (3)
3 MIN READ
0
Subatomic: From thermophiles to humans (2)
6 MIN READ
0
Subatomic: From thermophiles to humans
5 MIN READ
0
A reversible TCA cycle in a thermophile
5 MIN READ
0
A mental health problem at the highest level (3)
7 MIN READ
0
The MicroRNAome Strikes Back: A Sokalian hoax (10)
3 MIN READ
0
BiondVax Universal Flu Vaccine Patent
4 MIN READ
0
The MicroRNAome Strikes Back: A Sokalian hoax (8)
4 MIN READ
0
The MicroRNAome Strikes Back: A Sokalian hoax (6)
4 MIN READ
0
A mental health problem at the highest level (2)
3 MIN READ
0
Diet-driven RNA interference and cancer prevention (4)
4 MIN READ
0
Diet-driven RNA interference and cancer prevention (3)
6 MIN READ
0
Autophagy is the antiphage defense strategy (2)
4 MIN READ
0
Enzyme-constrained interethnic diversity (8)
< 1 MIN READ
0
Enzyme-constrained interethnic diversity (7)
6 MIN READ
0
Diet-driven RNA interference and cancer prevention (2)
< 1 MIN READ
0
Diet-driven RNA interference and cancer prevention
5 MIN READ
0
Enzyme-constrained interethnic biodiversity (6)
8 MIN READ
0
A Mathematical Model Links Quantum Physics to Quantum Souls (2)
4 MIN READ
0
The “walking fish” walks straight from quantum physics to quantum souls (4)
11 MIN READ
0
The “walking fish” walks straight from quantum physics to quantum souls (2)
3 MIN READ
0
The “walking fish” walks straight from quantum physics to quantum souls
6 MIN READ
0
A Mathematical Model Links Quantum Physics to Quantum Souls (1)
6 MIN READ
0
Kinetically Stable Thermodynamically Activated Cell Metabolism (4)
3 MIN READ
0
Kinetically Stable Thermodynamically Activated Cell Metabolism (1)
3 MIN READ
0
The tipping point (revisited): 68,000 publications
5 MIN READ
0
Agilent technology and energy-dependent autophagy
8 MIN READ
0
Elsevier fails to support the concept of autophagy
4 MIN READ
0
From Autophagy.pro (transitions)
4 MIN READ
0
Nature vs Science and Autophagy.pro
7 MIN READ
0
The overwhelming ignorance of sex researchers (2)
4 MIN READ
0
Trashing the 2nd Law
7 MIN READ
0
The overwhelming ignorance of sex researchers
5 MIN READ
0
Mouse morphs and primate diversity in 50 years
7 MIN READ
0
Two retractions of human idiocy
2 MIN READ
0
Exposing the 2nd Law to more ridicule (1)
6 MIN READ
0
Denying Creation via RNA-directed DNA methylation
4 MIN READ
0
Light-activated error free DNA repair (2)
8 MIN READ
0
Schrodinger’s answer to Schrodinger’s question
3 MIN READ
0
MicroRNAs and the Cassandra syndrome (revisited)
4 MIN READ
0
Epigenetic facts vs variable recombination theories
4 MIN READ
0
A mental health problem at the highest level
2 MIN READ
0
Pheromones biophysically constrain RNA-mediated biodiversity (1)
5 MIN READ
0
Pheromones biophysically constrain base editing and RNA editing
3 MIN READ
0
From base editing to RNA editing (4)
5 MIN READ
0
From base editing to RNA editing
2 MIN READ
0
Loss of energy as information (1)
3 MIN READ
0
Exome Sequencing Impact in Routine Care
4 MIN READ
0
Energy-dependent structure and function: Until death (3)
3 MIN READ
0
Energy-dependent structure and function: Until death (2)
5 MIN READ
0
Energy-dependent structure and function: Until death (1)
4 MIN READ
0
Until death: Virus-driven failure of multisensory integration (1)
4 MIN READ
0
Entertaining yourself to death
6 MIN READ
0
Thanks again for asking about DNA methylation
4 MIN READ
0
Predicting who wins the 2017 Nobel Prizes (2)
4 MIN READ
0
Predicting who wins the 2017 Nobel Prizes
4 MIN READ
0
Evolutionary theories of epigenetic drift
2 MIN READ
0
Evolution outside the context of “the light of evolution” (2)
3 MIN READ
0
Evolution outside the context of “the light of evolution”
6 MIN READ
0
Science vs Secularism: Molecular Mechanisms or Math?
6 MIN READ
0
Methylation and the Innate Immune System
< 1 MIN READ
0
Neurosteroids revisited two decades later
3 MIN READ
0
Host-derived creation of all pathology (2 of 2)
9 MIN READ
0
Host-derived creation of all pathology (1 of 2)
5 MIN READ
0
God vs host-derived creation of virus-driven pathology (2)
4 MIN READ
0
Energy and neural plasticity
< 1 MIN READ
0
Your indifference is killing you and others
5 MIN READ
0
Your indifference is killing you and others (2)
4 MIN READ
0
Your indifference is killing you and others (3)
4 MIN READ
0
Your indifference is killing you and others (4)
4 MIN READ
0
Robert Sapolsky’s legacy of atheistic pseudoscientific nonsense
4 MIN READ
0
The Origin of Information (4)
4 MIN READ
0
Can protein folding chemistry be understood by theorists?
5 MIN READ
0
The Origin of Information (3)
6 MIN READ
0
Irreconcilable differences: food energy vs de novo assembly
2 MIN READ
0
New Testament Book Cover Refutes Theistic Evolution
7 MIN READ
0
Energy-dependent physical and biophysical constraints (10)
8 MIN READ
0
Energy-dependent physical and biophysical constraints (9)
3 MIN READ
0
Energy-dependent physical and biophysical constraints (8)
5 MIN READ
0
Energy-dependent physical and biophysical constraints (7)
2 MIN READ
0
Energy-dependent physical and biophysical constraints (6)
8 MIN READ
0
Energy-dependent physical and biophysical constraints (5)
7 MIN READ
0
Energy-dependent physical and biophysical constraints (3)
2 MIN READ
0
Energy-dependent physical and biophysical constraints (2)
4 MIN READ
0
Energy-dependent physical and biophysical constraints (1)
5 MIN READ
0
Cell type assembly and the space-time continuum
2 MIN READ
0
Epigenetic effects of stress by Bruce McEwen (2)
3 MIN READ
0
The emergence of light as energy from a life-giving star
11 MIN READ
2
MicroRNAs GnRH and the failure of sex research
7 MIN READ
0
God’s shrinking role in salvation (2)
5 MIN READ
0
God’s shrinking role in salvation
8 MIN READ
0
Food energy-dependent cell type differentiation (2)
10 MIN READ
0
Hard Science vs the neo-Darwinian “magic box”
9 MIN READ
0
Infections and age change the odor of wine and people
4 MIN READ
0
From E. coli to monkeys and mankind: Theories vs models (5)
5 MIN READ
0
From E. coli to monkeys and mankind: Theories vs models (2)
6 MIN READ
0
From E. coli to monkeys and mankind: Theories vs models
7 MIN READ
0
Food energy-dependent epigenetic adaptation (3)
3 MIN READ
0
Food energy-dependent epigenetic adaptation (2)
< 1 MIN READ
0
Energy-dependent epigenetic translation to mRNA stability (4)
2 MIN READ
0
Energy-dependent epigenetic translation to mRNA stability (3)
5 MIN READ
0
Energy-dependent epigenetic translation to mRNA stability
8 MIN READ
0
UV light and non-coding RNA
2 MIN READ
0
What energy source do proteins prefer?
6 MIN READ
0
Energy-dependent microRNA biogenesis
4 MIN READ
0
Draining the academic swamp of parasites
3 MIN READ
0
The death of human ethology via ecology
7 MIN READ
0
Dispensing with all pseudoscientific nonsense about evolution (2)
< 1 MIN READ
0
Virus-driven downsizing of the human brain (4)
2 MIN READ
0
What is life without sunshine?
2 MIN READ
0
Viruses in pathogenic variants disrupt alternative splicings (2)
3 MIN READ
0
Viruses in pathogenic variants disrupt alternative splicings
2 MIN READ
0
Respiration-dependent endogenous RNA interference
4 MIN READ
0
Functionally interdependent editing and methylation
4 MIN READ
0
Cytosis: Biology Content
7 MIN READ
0
Harvard researchers support young earth creationism
< 1 MIN READ
0
Cytosis: A Cell Biology Board Game
< 1 MIN READ
0
Sal Giardina: apologetics revisited
8 MIN READ
0
Virulence and your UTI
2 MIN READ
0
Life in your UV light-constrained galaxy
5 MIN READ
0
Thinking about energy is not radical re-thinking
6 MIN READ
0
Proof: Sunlight is energy as information
< 1 MIN READ
0
Energy-dependent pheromone-controlled entropy (2)
6 MIN READ
0
The essence of precision medicine: drug targets or healthy longevity?
4 MIN READ
0
Allen Institute confirms food energy is information
6 MIN READ
0
RNA-mediated adult learning, memory, and neurogenesis
3 MIN READ
0
Energy-dependent allelic imbalances, viruses, and pathology
3 MIN READ
0
Biologically uninformed biologists fight back and lose
3 MIN READ
0
Theistic evolutionists fight back and lose (3)
4 MIN READ
0
Young earth creationists refute theistic evolution
3 MIN READ
0
Bill Gates refutes theistic evolution (sequel)
8 MIN READ
0
Bill Gates refutes theistic evolution
4 MIN READ
0
Emily Witkin refutes theistic evolution
2 MIN READ
0
Wikipedia refutes theistic evolution
4 MIN READ
0
RNA editing refutes theistic evolution
4 MIN READ
0
Pseudoscientists fail to refute theistic evolution
4 MIN READ
0
Stuart Kauffman refutes theistic evolution
3 MIN READ
0
May the anti-entropic force of sunlight be with you
4 MIN READ
0
Francis S. Collins refutes theistic evolution
6 MIN READ
0
Energy is information. Objections over ruled. You’re fired!
7 MIN READ
0
Happy Darwin Day (2017)
4 MIN READ
0
George Church refutes theistic evolution (3)
5 MIN READ
0
George Church refutes theistic evolution (2)
2 MIN READ
0
George Church refutes theistic evolution
5 MIN READ
0
Physicists: Desperate Acts (revisited)
6 MIN READ
0
Energy as information and constrained endogenous RNA interference (3)
4 MIN READ
0
Energy as information and constrained endogenous RNA interference (2)
2 MIN READ
0
Virus-driven energy theft and premature death
3 MIN READ
0
Fighting for virus-driven pathology
5 MIN READ
0
ATP-dependent creation of RNA
2 MIN READ
0
Dobzhansky 1973 and precision medicine (4)
5 MIN READ
0
Dobzhansky 1973 and Precision Medicine (2)
5 MIN READ
0
Science journalists or paid propagandists? (4)
6 MIN READ
0
Dobzhansky 1973 and precision medicine
6 MIN READ
0
Twisted theories and weaponized facts
3 MIN READ
0
Mutations: the “driving force” behind human brain complexity?
6 MIN READ
0
Mutations: the "driving force" behind human brain complexity?
6 MIN READ
0
Science journalists or paid propagandists? (2)
3 MIN READ
0
Theorists sell hidden energy (2)
4 MIN READ
0
Evolved patterns of brain stimulation
3 MIN READ
0
Energy-dependent chirality (2)
3 MIN READ
0
Energy-dependent chirality
6 MIN READ
0
Energy-dependent alternative splicings 1996 – 2016 (2)
5 MIN READ
0
Vietnam Veterans and others with glioblastoma
3 MIN READ
0
Energy-dependent sensory maps (1996-2016)
5 MIN READ
0
Energy-dependent alternative splicings 1996 – 2016
12 MIN READ
0
Energy-dependent oscillating gene networks organize life
4 MIN READ
0
2016 obfuscated facts about energy as information
5 MIN READ
0
More refutations of neo-Darwinian nonsense
7 MIN READ
0
Dietary lutein and pheromone-controlled brain development
4 MIN READ
0
Re-inventing mutation-driven evolution (2)
4 MIN READ
0
Anti-entropic virucidal energy as information
10 MIN READ
0
Bio-functional information
3 MIN READ
0
Expunging the distinguished public
2 MIN READ
0
Explorers who do not know what is known (2)
6 MIN READ
0
Energy-dependent natural translational selection
4 MIN READ
0
Autophagy is the antiphage defense strategy
3 MIN READ
0
Energy-dependent de novo creation and neurogenesis (2)
5 MIN READ
0
Energy-dependent de novo creation and neurogenesis
7 MIN READ
0
Theories vs facts about polycombic adaptation
3 MIN READ
0
Tasting light links energy from creation to adaptation
9 MIN READ
0
Politicized science: The demise of RNA-mediated.com?
3 MIN READ
0
The futility of The Battlefield FB group
10 MIN READ
0
Metabolic Phenotyping Research
2 MIN READ
0
Happy biophysically constrained Thanksgiving (in the USA)
3 MIN READ
0
De novo gene creation: Ignoring the experimental evidence
7 MIN READ
0
Light, behavior and autophagy, a gender-specific risk factor
4 MIN READ
0
Controlled amino acid treatment of all pathology
4 MIN READ
0
Energy-dependent purifying selection / autophagy (2)
2 MIN READ
0
Energy-dependent purifying selection / autophagy (3)
2 MIN READ
0
Energy-dependent purifying selection / autophagy (4)
2 MIN READ
0
Energy-dependent purifying selection / autophagy
2 MIN READ
0
Optogenetics: Let there be virucidal light!
2 MIN READ
0
Survivors of RNA-mediated terrorism
5 MIN READ
0
RNA-mediated terrorism
< 1 MIN READ
0
Building delicious base pairs in class. It’s elementary Watson and Crick
3 MIN READ
0
Building delicious base pairs in class. It's elementary Watson and Crick
3 MIN READ
0
RNA-mediated “repurposing” is autophagy
2 MIN READ
0
RNA-mediated "repurposing" is autophagy
2 MIN READ
0
Epigenetics and autophagy vs mutations and evolution (8)
4 MIN READ
0
Energy-dependent maternal-to-zygotic transition
6 MIN READ
1
Virus-driven mutation or amino acid substitution
5 MIN READ
0
Epigenetically effected energy-dependent fluorescence
5 MIN READ
0
Epigenetics and autophagy vs mutations and evolution (7)
3 MIN READ
0
Epigenetics and autophagy vs mutations and evolution (5)
2 MIN READ
0
Epigenetics and autophagy vs mutations and evolution (3)
< 1 MIN READ
0
Epigenetics and autophagy vs mutations and evolution (2)
2 MIN READ
0
Epigenetics and autophagy vs mutations and evolution
< 1 MIN READ
0
From Precis to Proof in 6000 years (3)
2 MIN READ
0
From precis to pre-mRNA and proof of concept in F1, F2, F3
6 MIN READ
0
Coulombic interactions facilitate polycombic adaptation
5 MIN READ
0
Top-down adaptation vs bottom-up evolution
6 MIN READ
0
Light ‘drives’ adaptation; nothing ‘drives’ evolution (2)
3 MIN READ
0
Demoncrats fight polycombic ecological adaptation
4 MIN READ
0
Polycombic ecological adaptation as a science, not a theory
3 MIN READ
0
Biological evolution as a philosophy, not a science
6 MIN READ
0
Attacking Young Earth Creationists
5 MIN READ
0
80 years of causal analysis (1936 – 2016)
11 MIN READ
0
Did evolution autophosphorylate your kinases? (3)
2 MIN READ
1
Predictable idiosyncratic evolved convergence
3 MIN READ
0
The natural success of RNAi and failed treatment
7 MIN READ
0
Virus-mediated hecatombic evolution
2 MIN READ
0
Hecatombic evolution via oncocers and oncohistones
9 MIN READ
0
Did evolution autophosphorylate your kinases? (2)
5 MIN READ
1
Nutrient-dependent autophagy
3 MIN READ
0
Nutrient-dependent pheromone-controlled autophagy (2)
6 MIN READ
0
Asking the right questions (2)
3 MIN READ
0
Nutrient-dependent pheromone-controlled autophagy
3 MIN READ
0
Life is energy-dependent task management (2)
3 MIN READ
0
Life is energy-dependent task management
3 MIN READ
0
Hypothesis free pseudoscience vs facts (5)
6 MIN READ
0
Hypothesis free pseudoscience vs facts (4)
5 MIN READ
0
Hypothesis free pseudoscience vs facts (1)
5 MIN READ
0
Base pairs, olfaction and RNA thermometers
4 MIN READ
0
Chromatin: The structure of DNA (2)
8 MIN READ
0
Chromatin: The structure of DNA (3)
4 MIN READ
0
Hydrogen-atom energy in DNA base pairs
6 MIN READ
0
Light energy-dependent active motifs
6 MIN READ
0
Light energy-induced base pair changes (2)
4 MIN READ
0
Light energy-induced base pair changes (1)
6 MIN READ
0
DNA repair via junk DNA (1)
5 MIN READ
0
Unconstrained mutations, Zika virus, Kallmann’s syndrome
4 MIN READ
0
Energy-dependent cellular communication
3 MIN READ
0
Conserved biophotonic emissions
7 MIN READ
2
Antithetical conclusions (5)
4 MIN READ
0
Antithetical conclusions (4)
3 MIN READ
0
Anthetical conclusions (2)
5 MIN READ
0
Anthetical conclusions
3 MIN READ
0
Non-random pheromone-controlled cell type differentiation
3 MIN READ
0
Co-evolution and co-speciation replace neo-Darwinian nonsense
4 MIN READ
0
Energy-dependent natural fluorescence and bioluminescence
2 MIN READ
0
Pseudoscientists ignore what serious scientists prove
6 MIN READ
0
GC-rich neo-Darwinian train wreck
5 MIN READ
0
From angstroms to ecosystems
7 MIN READ
0
Do weak bosons evolve into leptons?
4 MIN READ
0
Biophotonics, glycobiology, quantized biodiversity (2)
19 MIN READ
0
Biophotonics, glycobiology, quantized biodiversity
4 MIN READ
0
The Origin of Information (2)
6 MIN READ
0
The tipping point? 50,000 publications (5)
3 MIN READ
0
Light ‘drives’ adaptation; nothing ‘drives’ evolution
6 MIN READ
0
Did “Nature” kill Steve Jobs? (3)
10 MIN READ
0
Funding the Human Genome Project-Write
2 MIN READ
0
Did “Nature” kill Steve Jobs?
3 MIN READ
0
RNA methylation (revisited)
< 1 MIN READ
0
Virus-driven downsizing of the human brain
2 MIN READ
0
MicroRNAs and sexual orientation
8 MIN READ
0
RNA methylation, learning, memory and behavior,
< 1 MIN READ
0
Major transition ends use of silly theories
5 MIN READ
0
RNA methylation
2 MIN READ
0
Model vs theory: Progress report!
8 MIN READ
0
The Mind’s Eyes (revisited)
10 MIN READ
0
Cracking the Olfactory Code?
5 MIN READ
0
RNA methylation, behavior, and disease
6 MIN READ
0
Modelling life scientifically: RNA-mediated events
12 MIN READ
0
Energy-dependent RNA methylation (10)
4 MIN READ
0
Energy-dependent RNA methylation (6)
9 MIN READ
0
Energy-dependent RNA methylation (3)
10 MIN READ
0
Energy-dependent RNA methylation (2)
5 MIN READ
0
Thermotolerance and longevity (2)
3 MIN READ
0
War Games: False Flag Terrorism
5 MIN READ
0
Energy-dependent biodiversity
5 MIN READ
0
The tipping point? 50, 000 publications
4 MIN READ
0
Neo-Darwinism failed in 1995
3 MIN READ
0
Magic, Miracle, or Molecular Mechanism (3)
2 MIN READ
0
Magic, Miracle, or Molecular Mechanism (2)
8 MIN READ
0
Energy-dependent creation and entropy
4 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics (4)
5 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics (3)
5 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics (2)
7 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics
9 MIN READ
0
Wasted Templeton Funding (4)
3 MIN READ
0
RNA splicing, genetic variation, and disease
2 MIN READ
0
Wasted Templeton Funding (3)
2 MIN READ
0
Wasted Templeton Funding (2)
2 MIN READ
0
Magic, Miracle, or Molecular Mechanism?
10 MIN READ
0
Molecular Diagnostics: What is unprotected life? (2)
7 MIN READ
0
Creating and/or programming the immune system
< 1 MIN READ
0
Ricki Lewis’ Time Machine (3)
5 MIN READ
0
Creating nutrient-dependent life with enough genes to survive
3 MIN READ
0
Confusing effects and affects of visual input
2 MIN READ
0
Selective reporting of inferences: examples of pseudoscience
14 MIN READ
0
Energy-dependent purpose vs teleophobic telorexia
12 MIN READ
0
Virus-driven disorder prevention and health promotion
6 MIN READ
0
Stress-linked population-level history dependence
5 MIN READ
0
Jay R. Feierman: twenty years of antagonism
5 MIN READ
0
Do not miss the misrepresentations
2 MIN READ
0
Energy dependent RNA-mediated immunity (5)
4 MIN READ
0
Energy dependent RNA-mediated immunity (4)
6 MIN READ
0
Energy dependent RNA-mediated immunity (3)
8 MIN READ
0
Energy dependent RNA-mediated immunity (2)
10 MIN READ
0
The toxic river of neo-Darwinian pseudoscience
3 MIN READ
0
Science vs semantics
4 MIN READ
0
From angstroms to ecosystems and entropy
2 MIN READ
0
Bacteria see the light and they adapt (2)
5 MIN READ
0
Soil bacteria, bulls, cows, microRNAs, and mammary glands (2)
3 MIN READ
0
Soil bacteria, bulls, cows, microRNAs, and mammary glands
3 MIN READ
0
Bringing RNA back to epigenetics (20 years later)
11 MIN READ
0
Effects on invertebrate GnRH and affects on primate behavior
6 MIN READ
0
Creating gravity, nucleic acids, receptors, and supercoiled DNA (2)
9 MIN READ
0
Nutrient-dependent RNA-mediated cause and effect
3 MIN READ
0
Creating gravity, nucleic acids, receptors, and supercoiled DNA
2 MIN READ
0
Hydrogen-atom transfer in DNA base pairs (7)
5 MIN READ
0
Bacteria see the light and they adapt
7 MIN READ
0
The Light and Darkness of “Evolution 2.0”
11 MIN READ
0
Models of scientific literacy
3 MIN READ
0
Organic Compounds and the Miracle of Smell and Taste
7 MIN READ
0
Neuroscience Virtual Event vs AAAS Symposium
3 MIN READ
0
Cancer: Evolution 2.0’s Blind Spot
13 MIN READ
0
Despicable fools?
4 MIN READ
0
Ricki Lewis’ Time Machine
5 MIN READ
0
Virus-perturbed alternative splicings
3 MIN READ
0
Hydrogen-atom transfer in DNA base pairs (5)
10 MIN READ
0
Brain evolution?
< 1 MIN READ
0
Center stage RNA-mediated events (since 1996)
3 MIN READ
0
Hydrogen-Atom Transfer in DNA Base Pairs (4)
4 MIN READ
0
Blood test links atoms to ecosystems
2 MIN READ
0
A failed theory of cancer: two more decades of pseudoscience
5 MIN READ
0
Teleophobes vs teleophiles: a recent history
2 MIN READ
0
Ecological genomics: teleophobes respond (too late)
10 MIN READ
0
Genes, orchid odors, and pheromones from blonds
5 MIN READ
0
Amino acid substitutions, stress, and human behavior
3 MIN READ
0
RNA-mediated theory killers (11) (12) (13) (14) (15)
7 MIN READ
0
Finding peace and π in the light of H bond energy (2)
8 MIN READ
0
MicroRNA-mediated RNA epigenetics
2 MIN READ
0
RNA methylation, RNA-directed DNA methylation, learning and memory
3 MIN READ
0
Finding peace and π in the light of H bond energy
5 MIN READ
0
Epigenetic (re)programming of behavior (3)
5 MIN READ
0
Perry Marshall: too much information for atheist PZ Myers
3 MIN READ
0
Epigenetic (re)programming of behavior
4 MIN READ
0
Assumptions prove ignorance
5 MIN READ
0
Neo-Darwinian sink testing
2 MIN READ
0
Life history transitions and RNA-mediated survial
2 MIN READ
0
Did Brain Atrophy Evolve?
2 MIN READ
0
Did Dobzhansky see the UV light of creation?
10 MIN READ
0
Researchers rename, reshuffle, and reveal their ignorance
3 MIN READ
0
RNA-mediated theory killers (6) (7) (8) (9) (10)
5 MIN READ
0
Does metabolism link beneficial mutations to cancer?
10 MIN READ
0
Hydrogen-Atom Transfer in DNA Base Pairs (3)
3 MIN READ
0
Manufacturing fossil “evidence”
4 MIN READ
0
RNA-mediated theory killers (4)
9 MIN READ
0
RNA-mediated theory killers (5)
2 MIN READ
0
RNA-mediated theory killers (3)
7 MIN READ
0
Ecological adaptations you cannot live without
6 MIN READ
0
RNA-mediated regulatory mechanisms link microbes to humans (3)
5 MIN READ
0
Hydrogen-Atom Transfer in DNA Base Pairs (2)
< 1 MIN READ
0
Essential pseudoscientific concepts of atheism
3 MIN READ
0
RNA-mediated theory killers (2)
8 MIN READ
0
RNA-mediated theory killers
6 MIN READ
0
Natural cooperation and Evolution 2.0
6 MIN READ
0
A million dollar paradox?
2 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (4)
6 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (5)
4 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (3)
8 MIN READ
0
Teaching the biologically uninformed
3 MIN READ
0
Innovative Neurotechnologies Link Sunlight to Precision Medicine
4 MIN READ
0
Hydrogen-Atom Transfer in DNA Base Pairs
9 MIN READ
0
Neo-Darwinism vs the neocortex
4 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair
2 MIN READ
0
Life and death predicted by DNA methylation
3 MIN READ
0
Nutrient-dependent trophic analogs
3 MIN READ
0
Virally derived RNA molecules and cell types
2 MIN READ
0
Plasma created by sunlight and RNA–mediated epigenetic heredity
2 MIN READ
0
Positive feedback loops and epigenetic traps
2 MIN READ
0
Behavioral Immune System model
4 MIN READ
0
Stress-perturbed mitochondrial dysfunction
4 MIN READ
0
Understanding cell type differentiation
3 MIN READ
0
Let there be anti-entropic light (3)
6 MIN READ
0
Theorists can’t understand biology
6 MIN READ
0
Neuroplasticity
4 MIN READ
0
Sensationalizing no new mechanism
2 MIN READ
0
Cell type differentiation: atoms to ecosystems
2 MIN READ
0
Too complex for the Complex Biological Systems Alliance
4 MIN READ
0
More re-evolved functional structures?
2 MIN READ
0
Receptor methylation controls behavior
2 MIN READ
0
Rediscovering quantum behavior
2 MIN READ
0
From dust to genomic entropy?
3 MIN READ
0
Virus, transposon and plasmid evolution
< 1 MIN READ
0
Conserved molecular mechanisms
< 1 MIN READ
0
Models are not theories (2)
2 MIN READ
0
Models are not theories (1)
2 MIN READ
0
Fossils vs cell types and the brain
3 MIN READ
0
Can veterans and other prisoners escape pseudoscience?
2 MIN READ
0
eQTLs and ecological adaptation
< 1 MIN READ
0
RNA central and RNA-mediated.com
6 MIN READ
0
Ecological speciation. Get it, theorists?
< 1 MIN READ
0
Designing, engineering, and protecting biodiversity
3 MIN READ
0
The virome, microbiome, replisome and supercoiled DNA
2 MIN READ
0
Skip the politics; embrace the facts
5 MIN READ
0
Controled Stem Cell Expansion
3 MIN READ
0
Neo-Darwinian logic is nonsense
3 MIN READ
0
Human pheromone deniers: What’s next?
5 MIN READ
0
FREE* SAMPLE: Histone modification
4 MIN READ
0
700 million years of evolution?
5 MIN READ
0
Biophysically constrained or unconstrained?
2 MIN READ
0
Mutated mitochondrial genes vs Supercoiled DNA
2 MIN READ
0
RNA-mediated retrotransposon-mediated biodiversity
3 MIN READ
0
Mystery machine vs model (2)
2 MIN READ
0
Mystery machine vs model
2 MIN READ
0
Mystery machine vs medical intelligence
2 MIN READ
0
The Current State of Neuroscience
3 MIN READ
0
Cancer: forward and reverse
2 MIN READ
0
Energy and evolution: another opinion?
2 MIN READ
0
Keep the gay gene theory?
< 1 MIN READ
0
Bird watchers and RNAs in cancers
2 MIN READ
0
Supercoiled DNA constrains virus-driven genomic entropy
2 MIN READ
0
Let there be anti-entropic light (2)
4 MIN READ
0
Foundamentals of theory
4 MIN READ
0
Microbes to humans 2015 Nobel Prize
2 MIN READ
0
Is mainstream science in “Science” pseudoscience?
5 MIN READ
0
Metaphysical science vs theory
4 MIN READ
0
Mechanisms of stress: from genes to cancer
9 MIN READ
0
Viruses come alive: Tree of life pseudoscience
6 MIN READ
0
Theorists have not seen the light (2)
3 MIN READ
0
Gene creation (revisited)
2 MIN READ
0
Hijacked light energy and vertebrate pathology
4 MIN READ
0
Theorists have not seen the light
4 MIN READ
0
A 5-10K comparison of design principles to evolution
3 MIN READ
0
Alternative pre-mRNA splicing and ecological adaptation
7 MIN READ
0
Nucleic acids: Stability of DNA/RNA
2 MIN READ
0
Exosomes and the RNA-mediated future of medicine (3)
2 MIN READ
0
Exosomes and the RNA-mediated future of medicine (2)
< 1 MIN READ
0
Exosomes and the RNA-mediated future of medicine
5 MIN READ
0
Multi-omic analysis features (SNPs, miRNA)
3 MIN READ
0
Anti-entropic effects on the origin of life
< 1 MIN READ
0
Somatic hypermutation vs RNA-mediated events
2 MIN READ
0
From fertilization to RNA-mediated events and back
2 MIN READ
0
Phytochemical link from the sun to cell types
2 MIN READ
0
New anti-entropic microbes
3 MIN READ
0
Metabolic competition and cancer
2 MIN READ
0
Natural selection: an anti-entropic force?
2 MIN READ
0
Genome sequencing, cadherins, and quantum consciousness
6 MIN READ
0
“New” quantum biology. Pirating the old
3 MIN READ
0
Creating genes and species
3 MIN READ
0
Cell types, SNVs, CNVs, and chromosomes
3 MIN READ
0
A “new” code enables ecological adaptation
4 MIN READ
0
Thermotolerance and Longevity
57 MIN READ
0
Is life the balance between quantum and classical physics?
3 MIN READ
0
Anti-entropic containment of energy: symbiosis 1.0
5 MIN READ
0
RNA-mediated X chromosome inactivation
3 MIN READ
0
The “great filter” is an epigenetic trap
4 MIN READ
0
Atomic-resolution of cell type signaling
4 MIN READ
0
Information and communication (2)
6 MIN READ
0
Unraveling evolutionary pseudoscience
2 MIN READ
0
Eibi Nevo gets it wrong
3 MIN READ
0
Rs3827760 is Val370Ala and EDARV370A
3 MIN READ
0
From “Blood Music” to Evolution 2.0
5 MIN READ
0
Olfaction & the octopus and human genomes (2)
4 MIN READ
0
Olfaction & the octopus and human genomes
3 MIN READ
0
Protosuns, prebiotic molecules, proteins, and people
4 MIN READ
0
Mammalian-wide interspersed repeats (MIRs)
2 MIN READ
0
Ecological speciation vs revised evolutionary syntheses
6 MIN READ
0
Ecology replaces the extended evolutionary synthesis
4 MIN READ
0
The stability of organized genomes (4)
3 MIN READ
0
The stability of organized genomes (3)
3 MIN READ
0
The stability of organized genomes (2)
5 MIN READ
0
Epimutation.com: a domain of confusion
8 MIN READ
0
Light -induced nucleic acid-mediated gene duplication?
< 1 MIN READ
0
Is the best Chinese research from China?
3 MIN READ
0
The stability of organized genomes
5 MIN READ
0
Viruses, amino acids, and somatic cell types (3)
9 MIN READ
0
Viruses, amino acids, and somatic cell types (2)
5 MIN READ
0
Big Bang Cosmology vs Reality
< 1 MIN READ
0
RNA-mediated terms of virus-induced en-deer-ment
2 MIN READ
0
Domestication via a single amino acid substitution
2 MIN READ
0
Hematopoiesis and practopoiesis
4 MIN READ
0
RNA-mediated morphological AND behavioral phenotypes
2 MIN READ
0
Becoming biologically informed (3)
3 MIN READ
0
Easy editing: Reinventing our RNA world
3 MIN READ
0
Is photic-zone ribosomal diversity linked to all biodiversity?
2 MIN READ
0
Picornaviruses moving between primates (or not)
2 MIN READ
0
Riding the wrong direction
3 MIN READ
0
Decreased phenotypic variation: Faith in Facts
7 MIN READ
1
Faithfully repaired DNA
5 MIN READ
0
RNA-mediated gene duplication, fixation, and ecological adaptation
6 MIN READ
0
MicroRNA controlled growth and brain development
7 MIN READ
0
MicroRNA – controlled ecological adaptations
5 MIN READ
0
Becoming biologically informed
2 MIN READ
0
The RNA-mediated sum of our parts
2 MIN READ
0
Celebrating independence from ridiculous theories
3 MIN READ
0
“New” epigenetic mechanism for lifelong learning?
3 MIN READ
0
The sum of our RNA-mediated parts
2 MIN READ
0
microRNAs and memory: Why trust a theory?
2 MIN READ
0
Protein folding and Google page rank
2 MIN READ
0
Unconscious affect (revisited)
2 MIN READ
0
Iron, ferritin, thyroxine
2 MIN READ
0
“Evolution” of sex differences?
2 MIN READ
0
RNA-mediated cell type differentiation: Honeybee
< 1 MIN READ
0
Nutrient stress-induced RNA-mediated pathology
< 1 MIN READ
0
Amino acid substitutions are not mutations
2 MIN READ
0
RNA-mediated events from A to Z
2 MIN READ
0
“First” evidence
5 MIN READ
0
Hypotheses and mathematical philosophy
3 MIN READ
0
What I cannot create I eliminate from discussion
3 MIN READ
0
RNA-mediated development (3)
5 MIN READ
0
RNA-mediated development
2 MIN READ
0
Creating and maintaining the human virome
2 MIN READ
0
Healthy mutants
2 MIN READ
0
Uniquely epigenomic gene regulation
2 MIN READ
0
MicroRNAs and inappropriate functions
2 MIN READ
0
Rejecting pseudoscientific nonsense
6 MIN READ
1
Living the life that randomness created? (Sarcasm alert)
3 MIN READ
0
30 years of theoretical nonsense
3 MIN READ
0
microRNAs, glycosylation, and genomes
4 MIN READ
0
Unknown mechanisms and conclusions
2 MIN READ
0
Alternative splicings: epigenetics meets pharmacogenomics
4 MIN READ
0
Epigenetic regulation of aging by glycine and GnRH
5 MIN READ
0
Physicians who practice evolutionary medicine?
3 MIN READ
0
Pattern recognition: biogeochemical structure and function
5 MIN READ
0
Viruses and the human-like microbiome
3 MIN READ
0
Informing the biologically uninformed
< 1 MIN READ
0
Tweaking the story to fit the theory
5 MIN READ
0
Appetite for ingesting theories (raw)
< 1 MIN READ
0
I forgot. How do mutations cause evolution?
4 MIN READ
0
One amino acid substitution, genes, and brain activity
3 MIN READ
0
Batch effect vs epigenetic effects
3 MIN READ
0
Gene expression, immortality, and cancer
6 MIN READ
0
Missing a fact: microRNAs are genomic biomarkers
4 MIN READ
1
Bee-birthed epigenetics and primate cell types
5 MIN READ
0
A lighting requirement for life
11 MIN READ
3
Scientists lose. A sci-fi author gains credibility
2 MIN READ
0
Vitamin B3 and DNA repair
4 MIN READ
0
Bees and primates automagically evolve
3 MIN READ
0
Ignoring systems complexity (it’s too complicated)
3 MIN READ
0
Five years of Ferguson
2 MIN READ
0
Computing via phosphorylation and fixation
3 MIN READ
0
Virus-driven cancer treatment and prevention
2 MIN READ
0
The microbiome, pharmacogenetics, and privacy
< 1 MIN READ
0
A special issue on nutritional epigenetics
5 MIN READ
0
Retinoic acid + one receptor regulate the genome
3 MIN READ
0
Epigenetics: microRNAs effect an integrative pathway
4 MIN READ
0
Protein isoforms do not evolve
3 MIN READ
0
Tissue type variation and expression of genes
< 1 MIN READ
0
From gut bacteria to breast milk and back
5 MIN READ
0
Chance mutations — not natural selection
5 MIN READ
0
Viruses in gut microbes
4 MIN READ
0
Physics, chemistry, light, and life
2 MIN READ
0
Finding odor and taste receptors everywhere
6 MIN READ
0
Linking the origin of birds to dinosaurs
< 1 MIN READ
0
An epigenetic mark links algae, worms, and flies
2 MIN READ
0
Effect and affect of a single base-pair change
4 MIN READ
0
Tet3 regulation of nutrient-dependent cell type differentiation
4 MIN READ
0
Thermodynamics and protein folding landscapes
2 MIN READ
0
RNA-mediated silencing of a chromosome
3 MIN READ
0
Viruses, proteins, and gut metagenomes do not evolve
< 1 MIN READ
0
Pathology constrains X-linked evolution
2 MIN READ
0
Feedback loops link insects to human brains
2 MIN READ
0
Viruses and cell type differentiation
3 MIN READ
0
RNA-mediated cell types and precision medicine
5 MIN READ
0
DNA Methylation and organized genomes (2)
10 MIN READ
0
DNA Methylation and organized genomes
7 MIN READ
0
Misunderstanding cancer
7 MIN READ
0
Amino acid-dependent cell type differentiation
8 MIN READ
0
Nutrient-dependent RNA interference (2)
4 MIN READ
0
The Darwin Code by Greg Bear
13 MIN READ
0
Nutrient-dependent RNA interference
4 MIN READ
0
Mutisensory integration: watching the paradigm shift
12 MIN READ
0
Origin of life and cancer (1,2,3)
2 MIN READ
0
A genetic variant refutes neo-Darwinism
6 MIN READ
0
MicroRNAs and invasive phenotypes
< 1 MIN READ
0
Silencing genes and serious scientists
3 MIN READ
0
The miRNA/mRNA balance: a suboptimal strategy?
2 MIN READ
0
Nutrient-dependent microRNAs control cell types
6 MIN READ
0
MicroRNAs and memory
< 1 MIN READ
0
Deeply ingrained thoughts
< 1 MIN READ
0
Graphic misrepresentations of ecological adaptation
2 MIN READ
0
Too many targets for theories
3 MIN READ
0
Methylation maintains cell type differences (2)
2 MIN READ
0
Methylation maintains cell type differences
3 MIN READ
0
Creating nothing but a theory (3)
4 MIN READ
3
Creating nothing but a theory (2)
4 MIN READ
0
Creating nothing but a theory
4 MIN READ
0
Viruses and ecologically adapted animals
2 MIN READ
0
2 genes in 2 species (too expensive and too insignificant)
11 MIN READ
0
The quantum / classical RNA-mediated ‘tipping point’
3 MIN READ
0
Epigenetic effects of soil bacteria on plants
< 1 MIN READ
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4 MIN READ
0
Quantum correlations/pseudoscience
3 MIN READ
0
Anti-entropic solar energy
5 MIN READ
0
Mimicking claims and ignoring facts
4 MIN READ
0
Correctly modeling life on this planet
3 MIN READ
0
Correctly modeling ecological adaptation
4 MIN READ
0
Behavior (4): All responses are RNA-mediated in birds
4 MIN READ
0
Questions about life’s diversity
21 MIN READ
0
UV-light mutations and gene loss (not gain)
5 MIN READ
0
Virus-driven origin of life
2 MIN READ
0
Luis P. Villarreal tells it like it is
3 MIN READ
0
RNA-directed gene choice
5 MIN READ
0
Walk towards the light
< 1 MIN READ
0
Two types of microRNA are not double agents
2 MIN READ
0
Epigenetics Skeptism
5 MIN READ
0
Is DNA-directed transcription RNA-mediated?
2 MIN READ
0
Assembling yourself: Molecular self / other recognition
4 MIN READ
0
What about birds?
5 MIN READ
0
Virus-driven cell type differentiation
2 MIN READ
0
RNA directed DNA methylation and cell types
4 MIN READ
0
Implicating microRNAs in cancer
2 MIN READ
0
Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs
2 MIN READ
0
Reverse phosphorylation
7 MIN READ
0
RNA-mediated repurposing in microbes and adaptations in primate brains
2 MIN READ
0
RNA-mediated “repurposing” is nutrient-dependent and pheromone-controlled
3 MIN READ
0
RNA-mediated "repurposing" is nutrient-dependent and pheromone-controlled
3 MIN READ
0
From 3-D to epigenetically-effected 4-D genome make-up
5 MIN READ
0
Let there be anti-entropic light (1)
11 MIN READ
0
An epigenetic trap (the prequel)
5 MIN READ
0
Imagining that data historically supports evolutionary theory
7 MIN READ
0
Atheism: Arrogant, useless, and divisive ignorance
7 MIN READ
0
The anti-entropic force of "Nature"
2 MIN READ
0
Nutritional epigenetics, exercise, and immune system integrity
4 MIN READ
0
What if Darwin was not still dead?
2 MIN READ
0
Military combat training to fight disease (2)
3 MIN READ
0
Military combat training to fight disease
3 MIN READ
0
Theoretical physics and molecular biology
5 MIN READ
0
Atoms to ecosystems is not almost a molecular ecology
3 MIN READ
0
Epigenetic effects of viruses on cellular homeostasis (2)
2 MIN READ
0
RNA-mediated epigenetic modification via DNA-methylation
4 MIN READ
0
Quantum physics, quantum biology, and quantum consciousness
4 MIN READ
0
How fast can evolutionary theory be changed?
5 MIN READ
0
Biological energy and a microbiome model of a light-driven time machine
3 MIN READ
0
The biologically-based origin of the mammalian placenta (2)
6 MIN READ
0
Quantum Superpositions: let there be light
4 MIN READ
0
Are viruses microRNAs? (2)
5 MIN READ
0
Are viruses microRNAs?
3 MIN READ
0
Sneaking up from behind (2)
3 MIN READ
0
Sneaking up from behind
4 MIN READ
0
Quantum entanglement, mass, and biomass
4 MIN READ
0
Physicists: Desperate Acts
16 MIN READ
0
An epigenetic trap (the sequel)
10 MIN READ
0
Mute points: most are afraid to mention them
6 MIN READ
0
All of “like kind” (Part 2)
2 MIN READ
0
All of "like kind" in the (bigger) family
6 MIN READ
1
Environment epigenetically shapes the immune system
3 MIN READ
0
Beneficial microbes kill beneficial mutations
4 MIN READ
0
Constrained evolution is ecological adaptation
5 MIN READ
0
A single amino acid substitution differentiates cell types of E. coli
3 MIN READ
0
Unconstrained evolutionary innovability
4 MIN READ
0
RNA-protein interactions reveal biophysical to ecological landscapes
2 MIN READ
0
Mutagenesis: Replacing facts with theories
5 MIN READ
0
ISHE's human ethology group
2 MIN READ
0
Amino acid homeostasis for a Happy New Year!
6 MIN READ
0
Understanding cell type differentiation
3 MIN READ
0
From Hydra to humans vs a Lakatosian research program
4 MIN READ
0
Unified nutritional and molecular mechanisms
9 MIN READ
0
Removing natural selection; reshaping the horse; adjusting evolutionary theory
4 MIN READ
0
Communication, not mutations
2 MIN READ
0
Models by evolutionary biologists are not models
2 MIN READ
0
The future of physics predicts no future for evolutionary theory
3 MIN READ
0
Model organisms: the birds and the bees
3 MIN READ
0
Chemical ecology and RNA-mediated control of DNA loops
< 1 MIN READ
0
Atoms to ecosystems: Evolutionary theory vs the coelacanth
6 MIN READ
0
Jumping back: Science or Pseudoscience? (2)
2 MIN READ
0
Jumping back: Science or Pseudoscience?
6 MIN READ
0
Single-cell level assay of protein biosynthesis and degradation
2 MIN READ
0
Glycine and GnRH: Am I being pedantic?
4 MIN READ
0
Extensive molecular evidence vs ridiculous theories
2 MIN READ
0
Dual genomes: exposing the evolution industry
5 MIN READ
0
One test of bioenergetic health?
2 MIN READ
0
Meaningful dialogue, anonymous fools and idiot minions
4 MIN READ
0
Epigenetic pharmacology and RNA-mediated transciptional landscapes
3 MIN READ
0
RNA-mediated events and "The Theory of Everything"
4 MIN READ
0
Sackler Colloquium: Effects or AFFECTS on Behavior
2 MIN READ
0
Thermodynamic constraints and ecological adaptations sans evolution
6 MIN READ
0
Eliminating correlations from evolutionary ecology
6 MIN READ
0
RNA-mediated species specificity
2 MIN READ
0
Are mutations beneficial?
4 MIN READ
0
The key to science: experimental evidence
5 MIN READ
0
Ecological adaptations reported as evolution in insects and mammals
4 MIN READ
0
There’s a model for that!
5 MIN READ
0
Biologists puzzled by evolved RNAs and decaying DNA
6 MIN READ
0
SNPs and millions of small variations in the human genome
3 MIN READ
0
More than a bag of chemicals?
2 MIN READ
0
Achiral GnRH: no prophesy, just prediction
9 MIN READ
0
Nothing new under the sun, except pseudoscientific nonsense
6 MIN READ
0
Making sense of quotes scattered across disciplines
2 MIN READ
0
Intelligent viruses and cancers?
10 MIN READ
0
Complex behaviors of cell types in cancer
6 MIN READ
0
De novo DNA methylation?
3 MIN READ
0
RNA eclipses the importance of DNA to cell type differentiation
4 MIN READ
0
We need pattern recognition, not proclamations
3 MIN READ
0
We need pattern recognition, not a prologue
6 MIN READ
0
Pharmacogenomics
3 MIN READ
0
Sexual differentiation of cell types in plants
2 MIN READ
0
A model of MHC 'evolution'
2 MIN READ
0
From deep time into real time: What evolutionary processes?
10 MIN READ
0
In theory, or supported by experimental evidence?
5 MIN READ
0
It’s cell type differention, not cell fate determination (2)
3 MIN READ
0
Are evolutionary theorists 'nob ends'?
5 MIN READ
2
No excuses: Creation and the meaning of organismal complexity
7 MIN READ
0
Nutrient-dependent gene duplication in plants (but not animals?)
4 MIN READ
0
Evolutionary theorists justify fear of the Ebola viruses
2 MIN READ
0
Evolutionary theorists and evolutionary theists live under rocks
< 1 MIN READ
0
No understanding of biodiversity
2 MIN READ
0
Understanding physical forces of ecological variation and adaptation
< 1 MIN READ
0
Eliminating evolutionary theory
3 MIN READ
0
Behavioral ecology: please continue to believe in our fantasies
3 MIN READ
0
2014 and 2004 Nobel Prize in Medicine
3 MIN READ
0
RNA-mediated events: chromosomal rearrangements and genomic rearrangements
2 MIN READ
2
How much good can be attributed to social science theories?
< 1 MIN READ
0
RNA-mediated genetic engineering (Part 3)
< 1 MIN READ
0
RNA-mediated genetic engineering (Part 2)
3 MIN READ
0
RNA-mediated genetic engineering
2 MIN READ
0
RNA-mediated events are not a matter of faith
2 MIN READ
0
Color vision refutes the evolutionary dogma of gene duplication
4 MIN READ
0
Unassailable evidence vs assumptions
4 MIN READ
0
Forces of "Nature" limit dissemination of information
4 MIN READ
0
Genomic surveillance ends our world of RNA-mediated ecological adaptations
2 MIN READ
0
Systems biology and memory disorders
3 MIN READ
0
RNA-mediated cell type differentiation and behavior
3 MIN READ
0
Different physical locations and different molecular mechanisms of health and disease
2 MIN READ
0
Metabolism, fixation, health or neurodegerative disorder
2 MIN READ
0
Physics, Chemistry, and Molecular biology (PCMb)
2 MIN READ
0
Physics denied; pseudoscientific nonsense accepted
2 MIN READ
0
Ecological variation and niche construction: 1, 2, 3
6 MIN READ
0
Epigenetically-effected metabolic shifts and ecological adaptations
3 MIN READ
0
Evolving DNA before RNA
4 MIN READ
0
Stop evolutionary theorists. Kill cancers
3 MIN READ
0
Did our adapted mind evolve? (Revisited)
2 MIN READ
0
De novo gene Creation sans evolution of genes via mutations
4 MIN READ
0
Did our adapted mind evolve?
6 MIN READ
0
RNA-directed DNA methylation and RNA-mediated events
5 MIN READ
1
Miracles are not miracles to evolutionary theorists
2 MIN READ
0
Mathematical model: microRNA and epigenetic regulation
2 MIN READ
0
Seemingly futile cycles are not thermodynamically futile
3 MIN READ
0
Do bacterial proteins evolve?
3 MIN READ
0
“Kardashians” in science
< 1 MIN READ
0
Probable changes in connectivity
2 MIN READ
0
New technique used in report of atomic-level ecological adaptations
3 MIN READ
0
Can epigenetic inheritance occur without concurrent changes in morphology AND behavior?
3 MIN READ
0
Memory of repression and memory of behavior (2)
< 1 MIN READ
0
Memory of repression and memory of behavior
2 MIN READ
0
Quantum physics meets Evolutionary Psychology News
2 MIN READ
0
Nutrient-dependent pheromone-controlled exercise-induced physiques
< 1 MIN READ
0
Watching and waiting for more retractions
2 MIN READ
0
RNA-mediated ecological adaptations of teeth
4 MIN READ
0
A molecular visualizer of worthwhile molecular biology
2 MIN READ
0
RNA-mediated species diversification from microbes to primates
3 MIN READ
0
RNA-mediated events found everywhere
2 MIN READ
0
Reseachers think copy number variation is genetically determined
< 1 MIN READ
0
Some neuroscientists think a mutation led to human language development
< 1 MIN READ
0
Genotype, observed phenotype, and distinctly disordered behaviors
3 MIN READ
0
Is the problem an internet echo or Feierman's ethics?
2 MIN READ
0
Behavior (3): All responses are RNA-mediated in bees
3 MIN READ
0
RNA-mediated ecological adaptation is not evolution
2 MIN READ
0
Exploding genomes and chromosomal rearrangements via RNA-mediated events
2 MIN READ
0
Behavior (2): All responses are RNA-mediated not genetically-determined
4 MIN READ
0
Behavior: The first response is RNA-mediated not genetically-determined
3 MIN READ
0
Mechanisms that are not understood increase clarity
4 MIN READ
2
Pattern recognition and conserved receptors (TAARs)
5 MIN READ
0
Nutrient-dependent erythropoiesis and anemia
6 MIN READ
0
Evolutionary heritage or ecological adaptation? Racism versus reality
4 MIN READ
0
A relatively young branch of science called epigenetics
4 MIN READ
0
Insect homology and diversity attributed to mutations
2 MIN READ
0
Biophysically constrained beginnings of RNA and DNA
4 MIN READ
0
Baby talk: More misrepresentations of ecological adaptations
2 MIN READ
0
Comparing divergent model organisms
2 MIN READ
1
A microRNA-mediated mechanism that is epigenetically inherited
2 MIN READ
0
Epimutations: Attacking pseudoscientific dogmas
4 MIN READ
0
Order and disorder: Ecological adaptations not mutations
6 MIN READ
0
microRNAs differentiate neuronal cell types
3 MIN READ
0
microRNAs and species relationships
3 MIN READ
0
Drunks and Monkeys: Pseudoscientific nonsense
2 MIN READ
0
The quantum biology of consciousness
3 MIN READ
0
Behavior is receptor-mediated
10 MIN READ
0
Genes and Race: Human History?
2 MIN READ
0
Soft atheism: a case for Creation
< 1 MIN READ
0
Nutrition, pheromones and cancer (2)
2 MIN READ
0
Ecologically linked adapted ants and brains
2 MIN READ
0
MiRNAs methylation and ecological adaptation sans mutations
2 MIN READ
0
Not focused and self-aggrandizing
2 MIN READ
0
Nutrient-dependent cooperation vs cannibalism (video)
2 MIN READ
0
Another powerful refutation of mutation-initiated natural selection
4 MIN READ
0
The new light of chromosomal rearrangements
3 MIN READ
0
Darwinian theories vs Darwin's facts
2 MIN READ
0
Chromosomal rearrangements and ecological adaptations
4 MIN READ
0
The wrong picture of our evolution
4 MIN READ
0
96 fixed amino acid substitutions, not 96 genes
6 MIN READ
0
Jay R. Feierman
3 MIN READ
0
Don't tell the Creationists
2 MIN READ
0
Targeting a cancer gene
2 MIN READ
0
Alternative splicings (very technical)
2 MIN READ
0
Pulses of olfactory/pheromonal input
2 MIN READ
0
Social experiences epigenetically effect gene networks
2 MIN READ
0
Pheromone-controlled thermodynamics and cancer
2 MIN READ
0
Seeds of life: astrobiological theory and mutations theory
3 MIN READ
0
Your comment is awaiting moderation
2 MIN READ
0
Nutrient-dependent pheromone-controlled stickleback evolution
2 MIN READ
0
Functional coding variants are not mutations
2 MIN READ
0
Mirror neurons and microRNA: theory vs biological facts
4 MIN READ
0
Understanding the role of mutations and evolution
4 MIN READ
0
Evolution: innovations may have non-adaptive origins (sans mutations)
2 MIN READ
0
Pheromones and cancer
4 MIN READ
0
Are pheromones responsible for human body odour assessment?
2 MIN READ
0
Nutrient-dependent / pheromone-controlled social structure
2 MIN READ
0
A flawed model: no tripartate synapse in the adult brain
3 MIN READ
0
Evolved development of olfactory systems
2 MIN READ
0
Epigenetics and metabolism converge with pheromone production
2 MIN READ
0
Behavioral epigenetics in ecological context
2 MIN READ
0
Epigenetic maintenance of transcription / neuronal migration
2 MIN READ
0
Epigenetics and evolutionary success
< 1 MIN READ
0
Epigenetic effects underlie sexual preferences IV
< 1 MIN READ
0
Thinking about what we know (or not)
2 MIN READ
0
Epigenetic effects underlie sexual preferences II
3 MIN READ
0
The hormone-miRNA axis, life span, and sexual orientation
3 MIN READ
0
Fish Odor Syndrome
< 1 MIN READ
0
One of the clearest examples of epigenetic effects
< 1 MIN READ
0
Pheromone-induced learning: a NEW model?
2 MIN READ
0
Epigenetic effects underlie sexual preferences (duh, and food preferences)
2 MIN READ
0
Epigenetic effects on chromatin and regulatation of gene expression (in Archaea?)
2 MIN READ
0
The genetics myth meets the great pheromone myth
2 MIN READ
0
The challenges of a Darwinian approach to anything
3 MIN READ
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A key mutational event? More story-telling. Olfaction modulates vision.
4 MIN READ
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A key mutational event? That’s not very likely.
3 MIN READ
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Mutated genes and accidental intelligence?
< 1 MIN READ
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Desmond Morris Syndrome: No selective advantage
2 MIN READ
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Genetic Influences on Epigenetically Effected Disease
2 MIN READ
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Disorders of development: altered microRNA / messenger RNA balance
< 1 MIN READ
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Eat like a monkey; act like a monkey
2 MIN READ
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Human Pheromones: Epigenetic Effects on Hormones and Their Affects on Behavior
3 MIN READ
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Forum discussions: the most complained about member (866 words)
3 MIN READ
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Creation vs Evolution: Expression of a newly found gene
2 MIN READ
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Evolution at work sans random mutations
2 MIN READ
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Epistasis: Epigenetic effects of nutrient chemicals and their metabolism to pheromones
< 1 MIN READ
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Sex differences in Alzheimer's and everything else
2 MIN READ
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The logic of gene regulatory networks
3 MIN READ
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Creating new genes (and controlling diversity)
2 MIN READ
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The end of random mutations theory
2 MIN READ
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Epigenetic effects of viruses on cellular homeostasis
< 1 MIN READ
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Diet epigenetically effects development of the primate brain
< 1 MIN READ
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A “new” form of natural selection?
2 MIN READ
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Human pheromones determine our social behavior (REJECTED)
3 MIN READ
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Human pheromones: epigenetic effects
< 1 MIN READ
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Human Pheromones: theory vs models
3 MIN READ
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Human pheromones: another attempt to change the concept
3 MIN READ
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Human pheromones and the fusiform fooled you area for face recognition
3 MIN READ
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The Missing Transgenerational Epigenetic Links
2 MIN READ
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Society for Social Neuroscience Presentation scheduled 10/11/12
2 MIN READ
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Epigenetic effects on stochastic gene expression and evolutionary psychology
2 MIN READ
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The Ghost in Your Genes – BBC Horizon
< 1 MIN READ
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Embracing galaxy-wide, cellular, and brain complexity
2 MIN READ
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Insect to human cognition
2 MIN READ
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More complicated than 1-2-3
2 MIN READ
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Bio-CHEMICAL complexity
< 1 MIN READ
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What to do with research results: Warning!
2 MIN READ
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Mischaracterizations of adaptive evolution by psychologists and biologists
2 MIN READ
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Human pheromones and the epigenetic effects of isolation
2 MIN READ
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Transgenerational epigenetic inheritance of sexual orientation
2 MIN READ
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Natural selection and the behavior of whole organisms
< 1 MIN READ
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Natural selection: New insights are unlikely
< 1 MIN READ
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Natural Selection and the Complexity of the Genome
2 MIN READ
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Human pheromones: an epigenetic continuum from microbes to mammals
3 MIN READ
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Domain-specific Mental modules and models for behavior
2 MIN READ
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Biological facts constrain proponents of random mutations theory
2 MIN READ
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Pheromones, Reciprocity, and Prosocial Behavior
3 MIN READ
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Is the language of God the god problem? (1530 words)
6 MIN READ
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The Epigenetics of Drug Development and Cholesterol Levels
< 1 MIN READ
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Woefully ignorant politicians and popular science
2 MIN READ
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Epigenetic alterations due to stress
< 1 MIN READ
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Epigenetic effects on the evolution of behavior
2 MIN READ
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CB Nemeroff: Off Restriction
< 1 MIN READ
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Children’s healthy diets lead to healthier IQ
< 1 MIN READ
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More bird-brained behavior
2 MIN READ
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Transgenerational epigenetic inheritance via nutrient chemicals
1 MIN READ
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Human pheromones and IQ via neurogenic and socio-cognitive niche construction
2 MIN READ
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Human pheromones, nutrition, DNA, epigenetics
2 MIN READ
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Human pheromones and inner conflict about evolution (1102 words)
4 MIN READ
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Where is the love?
3 MIN READ
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Human Pheromones and Comparative Epigenomics
2 MIN READ
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Human Pheromone Facts and the Out of Africa Theory
3 MIN READ
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Smelling the difference between young and old
< 1 MIN READ
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Human pheromones and the visual appeal of other people (Part Four)
3 MIN READ
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A thought experiment
3 MIN READ
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Bickering theorists: opinions about selfish genes and group selection
2 MIN READ
1
Human pheromones: Olfaction, odor receptors, learning, memory, mood, brains and behavior
< 1 MIN READ
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A nutrient chemical and pheromone-dependent neurogenic niche
2 MIN READ
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Human Pheromones: The smell of the scientific universe expanding
< 1 MIN READ
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More than speculation: adaptive evolution in species from microbes to man
2 MIN READ
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Human Pheromones in Socioaffective Neuroscience & Psychology
2 MIN READ
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Love is a receptor-mediated event: the pervasive influence of the late Robert L. Moss
3 MIN READ
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Exercise Alters Epigenetics
2 MIN READ
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Researchers Investigate Epigenetic Patterns In Multiple Conditions
< 1 MIN READ
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Genes not culture drive humans forward (an antithetical approach)
< 1 MIN READ
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Cookbook chemistry: food odors and hormones
< 1 MIN READ
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The Perversion of Science by Evolutionary Psychologists
5 MIN READ
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Baiting the behaviorist(s)
3 MIN READ
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The Sex Lives of Insects
< 1 MIN READ
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Epigenetic ‘memory’ key to nature versus nurture
< 1 MIN READ
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Study results: Human pheromones affect women’s behavior
< 1 MIN READ
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Honeybees, food odors, and perfume
< 1 MIN READ
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Study results: Human pheromones influence human behavior
2 MIN READ
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For ethologists: Observation does not trump molecular biology
2 MIN READ
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Results: increased flirtatious behavior and self-reported attraction
2 MIN READ
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Human Pheromones and WHR: Pure conjecture?
< 1 MIN READ
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See also Metabolic genetics research paves way to treating diabetes and obesity “Breaking down complex conditions such as Type 2 Diabetes and obesity into the specific metabolic proteins and processes that underlie them offers a new approach to studying the genetics of these diseases and how they are interrelated, according to research presented today at the American Society of Human Genetics (ASHG) 2014 Annual Meeting in San Diego.”
This is the type of study that links results from Alpha Genomix to your health.
Re: Jennifer Doudna is already well on her way to winning a Nobel Prize for her works. See: CRISPR Pioneers Honored Influential researchers receive the 2015 Breakthrough Prizes in Life Sciences. By Molly Sharlach | November 18, 2014
“Jennifer Doudna of the University of California, Berkeley, were honored for discovering the details of CRISPR, a bacterial antiviral system that has been widely adapted for genetic engineering.”