Alzheimer's, microRNAs, and olfaction
(click to enlarge)
A Blood Test for Alzheimer’s? Circulating microRNAs could help doctors diagnose the neurodegenerative disease. By Jef Akst | July 30, 2013
Excerpt: “Testing the blood of 202 people for 140 different microRNAs (miRNAs), a team of researchers at Saarland University, in Germany, identified 12 RNA fragments circulating at consistently different levels in healthy people and patients with Alzheimer’s…”
My comment: In my model, the microRNA/messenger RNA balance is nutrient-dependent and pheromone-controlled. The epigenetic landscape becomes the physical landscape of DNA via the thermodynamics of intercellular signaling and intranuclear interactions. The result is nutrient-stress driven and social stress-driven alternative splicings that may initially benefit organism-level thermoregulation via creation of de novo olfactory receptor genes.
Increasing the number of olfactory receptor genes enables increased nutrient uptake. However, ongoing nutrient stress and/or social stress alter genetic predispositions for Alzheimer’s and other neurodegenerative diseases that until now have manifested themselves first in reduced olfactory acuity. This suggests to me that the role of the microRNAs might best be assessed in concert with smell testing to arrive more quickly at differential diagnoses in the future.
Want more on the same topic?
Swipe/Drag Left and Right To Browse Related Posts:
Codon optimality vs systemic fraud (5)
6 MIN READ
0
Photonics in Forensics (2)
2 MIN READ
0
The tipping point (revisited): 120K
2 MIN READ
0
Defeating disease and Communism (3)
2 MIN READ
0
Defeating Disease and Communism (2)
3 MIN READ
0
Defeating Disease and Communism (1)
< 1 MIN READ
0
Creationism, Communism and Corruption (1)
2 MIN READ
0
microRNA-mediated quantum error correction (4)
2 MIN READ
0
Optoribogenetic-driven sympatric speciation (1)
3 MIN READ
0
Viral microRNA-mediated pathology (2)
3 MIN READ
0
Bruce S. McEwen’s legacy: sympatric speciation (2)
5 MIN READ
0
Biological Function of Autophagy (2)
7 MIN READ
0
Biological Function of Autophagy (1)
2 MIN READ
0
MicroRNAs biophysically constrain Virus-driven pathology (4)
3 MIN READ
0
Pheromones biophysically constrain disease (1)
2 MIN READ
0
Geobiology vs Geovirology (1)
6 MIN READ
0
Chemogenetic kinetics (2): Extinction
6 MIN READ
0
Chemogenetic kinetics (1): Creation
3 MIN READ
0
Nutrient-dependent Pheromone-controlled cures (3)
4 MIN READ
0
Weaponized health information (6)
6 MIN READ
0
Abiogenesis vs microRNA Biogenesis (1)
3 MIN READ
0
Ecological Adaptations: From Angstroms to Ecosystems (1)
4 MIN READ
0
Light and life-sucking black holes (2)
2 MIN READ
0
Kohl and Francoeur at 25 (4)
3 MIN READ
0
Virus-driven downsizing of the human brain (5)
5 MIN READ
0
DS Wilson’s view of biophysically constrained life (2)
2 MIN READ
0
RNA processing and disease 2019 (1)
2 MIN READ
0
Non-random vs random selection for receptor clonotypes
3 MIN READ
0
Viral latency vs deadly paleoanthropology (2)
< 1 MIN READ
0
Light-activated ecological adaptation (1)
2 MIN READ
0
Energy-dependent thymic involution vs evolution (2)
4 MIN READ
0
From microRNA.pro to quantumsouls.pro (1)
4 MIN READ
0
Hide and seek with science facts (4)
< 1 MIN READ
0
Empirical Economics vs Affective Neuronal Selection
4 MIN READ
0
The perfect symmetry of nature
2 MIN READ
0
10,000 reasons to believe in biophysical constraints (3)
3 MIN READ
0
Creating an enzyme that kills theories (2)
6 MIN READ
0
Energy-dependent ‘futile cycles’ of autophagy
2 MIN READ
0
microRNA targeting efficacy refutes ridiculous theories
3 MIN READ
0
Natural models inspire future therapeutics
< 1 MIN READ
0
MicroRNA-mediated alternative splicing (revisited)
4 MIN READ
0
Misleading evidence, Raman Hyperspectroscopy and FB jail
6 MIN READ
0
Biologically uninformed science idiot: Self-defense (3)
5 MIN READ
0
From quantum physics to quantum souls (5)
2 MIN READ
0
The origin of information (5,4,3,2,1)
3 MIN READ
0
ATP and RNA-mediated chromosomal stability
3 MIN READ
0
Abiogenesis vs microRNA biogenesis
4 MIN READ
0
The eternal significance of microRNAs (3)
3 MIN READ
0
The eternal significance of microRNAs (1)
< 1 MIN READ
0
Part 2: Light-controlled cell biology (revisited)
2 MIN READ
0
Light-controlled cell biology (revisited)
6 MIN READ
0
Autophagy in health and disease (1)
3 MIN READ
0
From photons to the proton motive force (2)
3 MIN READ
0
Ecological adaptation: A new definition of heredity (1)
5 MIN READ
0
Conceptual critique: Innateness vs the death gene (2)
5 MIN READ
0
Conceptual critique: Innateness vs the death gene (1)
5 MIN READ
0
A reversible TCA cycle in a thermophile (3)
4 MIN READ
0
Anti-entropic sunlight: Schrödinger’s Creationist Secret? (4)
8 MIN READ
0
The MicroRNAome Strikes Back: A Sokalian hoax (4)
5 MIN READ
0
Diet-driven RNA interference and cancer prevention (3)
6 MIN READ
0
Autophagy is the antiphage defense strategy (2)
4 MIN READ
0
Enzyme-constrained interethnic diversity (7)
6 MIN READ
0
Diet-driven RNA interference and cancer prevention (2)
< 1 MIN READ
0
Enzyme-constrained interethnic biodiversity (3)
3 MIN READ
0
A Mathematical Model Links Quantum Physics to Quantum Souls (2)
4 MIN READ
0
Quantized energy-dependent viral trophism
4 MIN READ
0
The “walking fish” walks straight from quantum physics to quantum souls
6 MIN READ
0
Energy-dependent base editing and correction of mutations (3)
3 MIN READ
0
Tai Chi vs PTSD and cancer
< 1 MIN READ
0
Schrodinger’s answer to Schrodinger’s question
3 MIN READ
0
MicroRNAs and the Cassandra syndrome (revisited)
4 MIN READ
0
A null mutation and healthy longevity?
4 MIN READ
0
From base editing to RNA editing (4)
5 MIN READ
0
Predicting who wins the 2017 Nobel Prizes (3)
2 MIN READ
0
Sci-Hub vs limits on the dissemination of information
6 MIN READ
0
Inventing “Transcriptome Trajectory Turning Points”
2 MIN READ
0
Science vs Secularism: Molecular Mechanisms or Math?
6 MIN READ
0
God vs host-derived creation of virus-driven pathology (2)
4 MIN READ
0
Stem cells do not create themselves
3 MIN READ
0
Your indifference is killing you and others
5 MIN READ
0
Robert Sapolsky’s legacy of atheistic pseudoscientific nonsense
4 MIN READ
0
Automagical protein creation sans energy
9 MIN READ
0
Energy-dependent physical and biophysical constraints (5)
7 MIN READ
0
Energy-dependent physical and biophysical constraints (1)
5 MIN READ
0
The emergence of light as energy from a life-giving star
11 MIN READ
2
God’s shrinking role in salvation (2)
5 MIN READ
0
CRISPR Cas9 technology refutes theistic evolution
5 MIN READ
0
UV light and non-coding RNA
2 MIN READ
0
Draining the academic swamp of parasites
3 MIN READ
0
Ignoring peer review, ATP, and microRNA biosynthesis
5 MIN READ
0
Food and pheromone-constrained healthy longevity
2 MIN READ
0
Open Science: Closed to facts about microRNAs
6 MIN READ
0
Viruses in pathogenic variants disrupt alternative splicings
2 MIN READ
0
Cytosis: Gameplay Runthrough
3 MIN READ
0
Cytosis: Biology content (2)
5 MIN READ
0
Functionally interdependent editing and methylation
4 MIN READ
0
Cytosis: A Cell Biology Board Game
< 1 MIN READ
0
Life in your UV light-constrained galaxy
5 MIN READ
0
Energy-dependent pheromone-controlled entropy (3)
2 MIN READ
0
Energy-dependent pheromone-controlled entropy (2)
6 MIN READ
0
Ab initio cell wall invention, emergence, and evolution (2)
8 MIN READ
0
May the anti-entropic force of sunlight be with you
4 MIN READ
0
George Church refutes theistic evolution
5 MIN READ
0
Physicists: Desperate Acts (revisited)
6 MIN READ
0
Fighting for virus-driven pathology
5 MIN READ
0
Science journalists or paid propagandists? (4)
6 MIN READ
0
Autophagy: from pre-mRNAs to microRNAs, enhancers, QTLs et al.
6 MIN READ
0
Chirality is reality
6 MIN READ
0
Energy-dependent alternative splicings 1996 – 2016
12 MIN READ
0
Re-inventing mutation-driven evolution (2)
4 MIN READ
0
Sudden death indel polymorphism
4 MIN READ
0
Energy-dependent de novo creation and neurogenesis
7 MIN READ
0
Theories vs facts about polycombic adaptation
3 MIN READ
0
Tasting light links energy from creation to adaptation
9 MIN READ
0
Energy-dependent coulombic, autophagic, polycombic healthy longevity
4 MIN READ
0
Base pairs, amino acids and phenotypes
10 MIN READ
0
Energy-dependent maternal-to-zygotic transition
6 MIN READ
1
The human virome (revisited)
4 MIN READ
0
Nutrient-dependent autophagy
3 MIN READ
0
Hydrogen-atom energy in DNA base pairs
6 MIN READ
0
Linking RNA structure to function
3 MIN READ
0
Exosomes, Inflammatory Disease, Pathogenesis, Treatment
< 1 MIN READ
0
Antithetical conclusions (4)
3 MIN READ
0
Anthetical conclusions (2)
5 MIN READ
0
Pseudoscientists ignore what serious scientists prove
6 MIN READ
0
The end of neo-Darwinism
5 MIN READ
0
Biophotonics, glycobiology, quantized biodiversity
4 MIN READ
0
Placing boundaries where none exist
< 1 MIN READ
0
Innate immunity and multiplexing
7 MIN READ
0
Amino acids and virus penetration
3 MIN READ
0
RNA methylation
2 MIN READ
0
Energy-dependent RNA methylation (7)
7 MIN READ
0
Energy-dependent RNA methylation (1)
6 MIN READ
0
War Games: False Flag Terrorism
5 MIN READ
0
The tipping point? 50, 000 publications
4 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics (4)
5 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics (2)
7 MIN READ
0
Confusing effects and affects of visual input
2 MIN READ
0
Selective reporting of inferences: examples of pseudoscience
14 MIN READ
0
Ignore the evidence: Rachel Feltman
5 MIN READ
0
Stress-linked population-level history dependence
5 MIN READ
0
Jay R. Feierman: twenty years of antagonism
5 MIN READ
0
From angstroms to ecosystems and entropy
2 MIN READ
0
Virus-perturbed alternative splicings
3 MIN READ
0
The radical pair mechanism of ecological speciation
3 MIN READ
0
Center stage RNA-mediated events (since 1996)
3 MIN READ
0
Stress-induced energy-dependent DNA repair
4 MIN READ
0
Researchers rename, reshuffle, and reveal their ignorance
3 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (4)
6 MIN READ
0
Sulfated steroids and RNA-mediated identity codes
< 1 MIN READ
0
RNA-mediated everything
4 MIN READ
0
Theorists can’t understand biology
6 MIN READ
0
RNA central and RNA-mediated.com
6 MIN READ
0
The virome, microbiome, replisome and supercoiled DNA
2 MIN READ
0
Skip the politics; embrace the facts
5 MIN READ
0
700 million years of evolution?
5 MIN READ
0
Preventing genomic entropy
4 MIN READ
0
Supercoiled DNA constrains virus-driven genomic entropy
2 MIN READ
0
Let there be anti-entropic light (2)
4 MIN READ
0
Is mainstream science in “Science” pseudoscience?
5 MIN READ
0
Metaphysical science vs theory
4 MIN READ
0
Gene creation (revisited)
2 MIN READ
0
Theorists have not seen the light
4 MIN READ
0
The creation and activation of GPCRs
4 MIN READ
0
Alternative pre-mRNA splicing and ecological adaptation
7 MIN READ
0
Nucleic acids: Stability of DNA/RNA
2 MIN READ
0
Exosomes and the RNA-mediated future of medicine (2)
< 1 MIN READ
0
Phytochemical link from the sun to cell types
2 MIN READ
0
Genome sequencing, cadherins, and quantum consciousness
6 MIN READ
0
“New” quantum biology. Pirating the old
3 MIN READ
0
Anti-entropic containment of energy: symbiosis 1.0
5 MIN READ
0
The “great filter” is an epigenetic trap
4 MIN READ
0
Protosuns, prebiotic molecules, proteins, and people
4 MIN READ
0
The stability of organized genomes (3)
3 MIN READ
0
Viruses, amino acids, and somatic cell types (2)
5 MIN READ
0
Picornaviruses moving between primates (or not)
2 MIN READ
0
Becoming biologically informed (2)
3 MIN READ
0
The RNA-mediated sum of our parts
2 MIN READ
0
Is SUMOylation RNA-directed DNA methylation? (revisited)
4 MIN READ
0
“New” epigenetic mechanism for lifelong learning?
3 MIN READ
0
RNA-mediated development (2)
< 1 MIN READ
0
microRNAs, glycosylation, and genomes
4 MIN READ
0
Alternative splicings: epigenetics meets pharmacogenomics
4 MIN READ
0
Epigenetic regulation of aging by glycine and GnRH
5 MIN READ
0
Pattern recognition: biogeochemical structure and function
5 MIN READ
0
Viruses and the human-like microbiome
3 MIN READ
0
Informing the biologically uninformed
< 1 MIN READ
0
Batch effect vs epigenetic effects
3 MIN READ
0
Missing a fact: microRNAs are genomic biomarkers
4 MIN READ
1
Ignoring systems complexity (it’s too complicated)
3 MIN READ
0
Virus-driven cancer treatment and prevention
2 MIN READ
0
A special issue on nutritional epigenetics
5 MIN READ
0
Retinoic acid + one receptor regulate the genome
3 MIN READ
0
Epigenetics: microRNAs effect an integrative pathway
4 MIN READ
0
Effect and affect of a single base-pair change
4 MIN READ
0
RNA-mediated silencing of a chromosome
3 MIN READ
0
Amino acid-dependent cell type differentiation
8 MIN READ
0
Nutrient-dependent RNA interference (2)
4 MIN READ
0
The Darwin Code by Greg Bear
13 MIN READ
0
Silencing genes and serious scientists
3 MIN READ
0
The miRNA/mRNA balance: a suboptimal strategy?
2 MIN READ
0
Nutrient-dependent microRNAs control cell types
6 MIN READ
0
MicroRNAs and memory
< 1 MIN READ
0
Creating nothing but a theory (2)
4 MIN READ
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4 MIN READ
0
Quantum correlations/pseudoscience
3 MIN READ
0
Mimicking claims and ignoring facts
4 MIN READ
0
Correctly modeling ecological adaptation
4 MIN READ
0
Reverse phosphorylation
7 MIN READ
0
From 3-D to epigenetically-effected 4-D genome make-up
5 MIN READ
0
Let there be anti-entropic light (1)
11 MIN READ
0
Nutritional epigenetics, exercise, and immune system integrity
4 MIN READ
0
What if Darwin was not still dead?
2 MIN READ
0
Military combat training to fight disease
3 MIN READ
0
Epigenetic effects of viruses on cellular homeostasis (2)
2 MIN READ
0
Are viruses microRNAs? (2)
5 MIN READ
0
Sneaking up from behind
4 MIN READ
0
All of “like kind” (Part 2)
2 MIN READ
0
Constrained evolution is ecological adaptation
5 MIN READ
0
Mutagenesis: Replacing facts with theories
5 MIN READ
0
Single-cell level assay of protein biosynthesis and degradation
2 MIN READ
0
One test of bioenergetic health?
2 MIN READ
0
Are mutations beneficial?
4 MIN READ
0
Biologists puzzled by evolved RNAs and decaying DNA
6 MIN READ
0
Achiral GnRH: no prophesy, just prediction
9 MIN READ
0
Intelligent viruses and cancers?
10 MIN READ
0
We need pattern recognition, not a prologue
6 MIN READ
0
From deep time into real time: What evolutionary processes?
10 MIN READ
0
In theory, or supported by experimental evidence?
5 MIN READ
0
Behavioral ecology: please continue to believe in our fantasies
3 MIN READ
0
Systems biology and memory disorders
3 MIN READ
0
RNA-mediated cell type differentiation and behavior
3 MIN READ
0
Metabolism, fixation, health or neurodegerative disorder
2 MIN READ
0
Evolving DNA before RNA
4 MIN READ
0
Stop evolutionary theorists. Kill cancers
3 MIN READ
0
RNA-directed DNA methylation and RNA-mediated events
5 MIN READ
1
Can epigenetic inheritance occur without concurrent changes in morphology AND behavior?
3 MIN READ
0
RNA-mediated events found everywhere
2 MIN READ
0
Behavior (3): All responses are RNA-mediated in bees
3 MIN READ
0
Exploding genomes and chromosomal rearrangements via RNA-mediated events
2 MIN READ
0
Behavior: The first response is RNA-mediated not genetically-determined
3 MIN READ
0
A relatively young branch of science called epigenetics
4 MIN READ
0
Biophysically constrained beginnings of RNA and DNA
4 MIN READ
0
Comparing divergent model organisms
2 MIN READ
1
A microRNA-mediated mechanism that is epigenetically inherited
2 MIN READ
0
Order and disorder: Ecological adaptations not mutations
6 MIN READ
0
microRNAs differentiate neuronal cell types
3 MIN READ
0
microRNAs and species relationships
3 MIN READ
0
Drunks and Monkeys: Pseudoscientific nonsense
2 MIN READ
0
The quantum biology of consciousness
3 MIN READ
0
Behavior is receptor-mediated
10 MIN READ
0
Genes and Race: Human History?
2 MIN READ
0
Soft atheism: a case for Creation
< 1 MIN READ
0
MiRNAs methylation and ecological adaptation sans mutations
2 MIN READ
0
Cell-type differentiation
2 MIN READ
0
Another powerful refutation of mutation-initiated natural selection
4 MIN READ
0
96 fixed amino acid substitutions, not 96 genes
6 MIN READ
0
Social experiences epigenetically effect gene networks
2 MIN READ
0
Pheromone-controlled thermodynamics and cancer
2 MIN READ
0
Understanding the role of mutations and evolution
4 MIN READ
0
Pheromones and cancer
4 MIN READ
0
Constraints on mutational drift
< 1 MIN READ
0
Epigenetic effects underlie sexual preferences IV
< 1 MIN READ
0
The hormone-miRNA axis, life span, and sexual orientation
3 MIN READ
0
MicroRNA binds messenger RNA: Adaptive Evolution
< 1 MIN READ
0
Genetic Influences on Epigenetically Effected Disease
2 MIN READ
0
Disorders of development: altered microRNA / messenger RNA balance
< 1 MIN READ
0
Evolution at work sans random mutations
2 MIN READ
0
Sex differences in Alzheimer's and everything else
2 MIN READ
0
Transgenerational epigenetic inheritance via nutrient chemicals
1 MIN READ
0