Summary: No ecosystems exist at any level of examination outside the context of the anti-entropic virucidal energy of light-activated endogenous substrates in all cell types of all living genera. The quantized energy-dependent creation of nucleotides links the creation of sunlight to fixation of energy in every organism on Earth.  Fixation of the energy is microRNA-mediated. The energy-dependent creation of microRNAs has been linked to healthy longevity via direct effects on organized genomes. For example, microRNAs typically biophysically constrain viral latency. Simply put, they prevent the virus-driven theft of quantized energy and degradation of messenger RNA that all serious scientists have linked from mutations to all pathology.

Cytosis is a transport mechanism for the movement of large quantities of molecules into and out of cells. There are three main types of cytosis: endocytosis (into the cell), exocytosis (out of the cell), and transcytosis (through the cell, in and out).

Every aspect of cytosis is quantized energy-dependent. Energy is information and facts about food energy have been placed into the following context.

Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013 free)

…the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. The role of the microRNA/messenger RNA balance [see the citations] in adaptive evolution will certainly be discussed in published works that will follow.

More than 73,000 indexed works mention microRNA

See also: microRNA + autophagy

See for example:  MicroRNA-155 regulates Inflammatory Response in Ischemic Cerebral Tissues through autophagy.

See also: From Oxidative Stress Damage to Pathways, Networks, and Autophagy via MicroRNAs (2018 free)

Conclusion:

Firstly, the data we have generated can be used as a starting point and resource for the generation of testable hypotheses and further experimental research to address specific questions related to the role of miRNAs in oxidative stress-mediated biological responses. Secondly, the study has value as a proof of principle of how in silico analyses can be used to make advances from already existing data in the field of miRNAs and oxidative stress. Indeed, as the experimental data on oxidative stress-modulated miRNAs, their gene targets, and their biological effects are continuously increasing, there will be more and more to gain by utilizing types of in silico approaches like the ones applied in the present paper. Our study shows that we already have come to the point where such analyses can provide meaningful and useful output, which otherwise would be very hard to reach. We therefore envision an important role for this line of research to be constantly evolving and integrated with biological experimental work, to accelerate our advances in the understanding of the oxidative stress response.

Yesterday, the biologically uninformed science journalist, John Hewitt reported on Equilibrative Nucleoside Transporter 3 Regulates T Cell Homeostasis by Coordinating Lysosomal Function with Nucleoside Availability

Metabolism and immunity are considered distinct physiological activities: metabolism is responsible for the processing and disposal of nutrients, whereas immunity guards the body from pathogen invasion. Nevertheless, both act to regain body homeostasis. Recent advances suggest a strong link between immunity and metabolism (O’Neill et al., 2016) because their balance affects each other. Although inflammation contributes to metabolic dysregulation (Hotamisligil and Erbay, 2008), starvation impairs immune responses (Demas et al., 2003), and over-nutrition, such as type 2 diabetes, induces chronic inflammation (Donath and Shoelson, 2011, Shu et al., 2012). It is becoming apparent that steady energy flux and metabolic homeostasis are crucial for the immune system to function properly.

Metabolism is quantized energy-dependent. Quantized energy from the sun typically is biophysically constrained in food and what organisms eat is linked from metabolism to autophagy and homeostasis in all living genera via the physiology of pheromone-controlled reproduction in species from microbes to humans.

See John Hewitt’s nonsense: Nucleoside logic: Supply-side programming of the immune biocomputer (with my emphasis)

The local nucleotide ecosystem that predominates within any cell or tissue can be considered a matrix unto itself. As an example, we might consider that each row and column of such a transition matrix will need to have entries not just for the standard bases (A,G,C,T,U), but also all the intermediary bases and breakdown products which come into play (like inosine and xanthine). Additionally, we would also need to include the successive stages of processing of each nucleobase through the nucleoside form, and then the monophosphate, diphosphate, and triphosphate nucleotide forms, and ultimately generation of the deoxynucleotide for the DNA. Each cell type will have only a partial ability to make each transition represented in such a matrix because each cell only possesses a subset of the all the corresponding enzymes available in the genome.

The creation of nucleotides is energy-dependent and no ecosystems exist at any level of examination outside the context of the anti-entropic virucidal energy of light-activated endogenous substrates in all cell types of all living genera. The creation of sunlight is required for fixation of energy in every organism on Earth.  Fixation of the energy is microRNA-mediated. The energy-dependent creation of microRNAs has been linked to healthy longevity via their effects on organized genomes. MicroRNAs typically biophysically constrain viral latency. Simply put, they prevent the virus-driven degradation of messenger RNA that all serious scientists have linked from mutations to all pathology.

See also: Brain inflammatory cascade controlled by gut-derived molecules

Metabolite molecules produced by the gut’s microbes activate immune cells in the brain called microglia, which signal to astrocyte cells to mediate responses to inflammation in the central nervous system.
 

Ask a biologically uninformed science idiot: “Where do the metabolite molecules come from?” If their answer is food, see Food energy  (video) and Energy as information and constrained endogenous RNA interference

See also: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene

A single A to I conversion in the seed of miR-376a-5p, for example, redirects the edited miRNA to a new set of mRNA targets [25]. In deep sequencing libraries, this conversion is marked by the substitution of A with G.

Every other aspect of biophysically contrained viral latency starts with energy-dependent changes in base pairs. The changes are linked from microRNA-mediated cell type differentiation to healthy longevity or from the virus-driven theft of quantized energy to all pathology.

See also: MicroRNA.pro Welcome to microrna.pro This Web page is parked FREE

It is time to move forward. The domain will soon become an active source of information on how the energy-dependent creation of microRNAs must be linked from subatomic particles and cytosis to biophysically constrained viral latency by autophagy in the context of the physiology of reproduction and pheromones that help to prevent all pathology.

Pseudoscientists, other theorists, and biologically uninformed science journalists who have failed to link Food energy  from Energy as information and constrained endogenous RNA interference will continue to mislead you. They hope that you will continue to believe in mutation-driven evolution and Big Bang cosmology. Ultimately, you will learn the truth from anyone age 10+ who plays Subatomic and/or Cytosis.

Until then, see also (or search for microRNA and the disease you want to learn more about):

Epigenetic silencing of miR-200b is associated with cisplatin resistance in bladder cancer

MicroRNAs as potential liquid biopsy biomarkers in colorectal Cancer: A systematic review.

MicroRNA-1 overexpression increases chemosensitivity of non-small cell lung cancer cells by inhibiting autophagy related 3-mediated autophagy.

MicroRNA Expression Profiling in Psoriatic Arthritis

Endothelial Replicative Senescence Delayed by the Inhibition of MTORC1 Signaling Involves MicroRNA-107

SIRT1, miR-132 and miR-212 link human longevity to Alzheimer’s Disease.

The Involvement of MicroRNAs in Modulation of Innate and Adaptive Immunity in Systemic Lupus Erythematosus and Lupus Nephritis.

MicroRNA Expression Profiling in Behçet’s Disease.

The Challenges and Opportunities in the Clinical Application of Noncoding RNAs: The Road Map for miRNAs and piRNAs in Cancer Diagnostics and Prognostics.

7/25/13
Jay R. Feierman:

Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.

See for comparison: A Novel Model for Predicting Associations between Diseases and LncRNA-miRNA Pairs Based on a Newly Constructed Bipartite Network.

LncRNAs and microRNA play significant roles in various biological processes. Therefore, developing effective computational models for predicting novel associations between diseases and lncRNA-miRNA pairs (LMPairs) will be beneficial to not only the understanding of disease mechanisms at lncRNA-miRNA level and the detection of disease biomarkers for disease diagnosis, treatment, prognosis, and prevention, but also the understanding of interactions between diseases and LMPairs at disease level.

The interactions between the diseases and LMPairs at disease level are quantized energy-dependent and biophysically constrained by the physiology of pheromone-controlled reproduction in species from microbes to humans.

 

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