Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways 7/28/22

Glyoxylate forms both glycine and orotate and reacts with malonate and urea to form aspartate and dihydroorotate. These results, along with the previously demonstrated protometabolic analogues of the Krebs cycle, suggest that there can be a natural emergence of congruent forerunners of biological pathways with the potential for seamless transition from prebiotic chemistry to modern metabolism.

Reported as: Scientists discover new ‘origins of life’ chemical reactions  7/28/22 “We’ve come up with a new paradigm to explain this shift from prebiotic to biotic chemistry,”

Can amino acids start forming small proteins? Could one of those proteins come back and begin to act as an enzyme to make more of these ?

Previously reported in the context of fixation of amino acids in microtubules and biophysically constrained viral endemicity across kingdoms during the past ~6000 years as: Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections 4/23/20

See also:

Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20

We propose a model revisiting the architecture of RNA-peptide interactions at the origin of life.

See for comparison: A universal trend of amino acid gain and loss in protein evolution 2/10/05

Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.

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