Primers: From photons to the proton motive force (1) and From photons to the proton motive force (2)

George Church, Feng Zhang, Francis S. Collins, Stuart Kauffman, Emily Witkin, and Bill Gates are joined by Carl Zimmer. All have now refuted theistic evolution via their failed attempts to link photons from mutations to the proton motive force, or their ridiculous claims linked to the magic of evolution.

Carl Zimmer may be the only so-called science journalist to have published a thinly disguised refutation of neo-Darwinian pseudoscientific nonsense..

See: Whole-Genome-Sequence-Based Haplotypes Reveal Single Origin of the Sickle Allele during the Holocene Wet Phase

Starting from first principles of population genetics, we defined haplotypes on the basis of phased sequence data. In contrast, the classical haplotypes were based on patterns of restriction sites seen in individuals with sickle cell anemia.3, 4

The  haplotypes are not defined. They are energy-dependent ecological adaptations.

A haplotype has been identified among Sudanese individuals that was classified as atypical but might be a fifth African haplotype.54 It is possible that sampling additional populations could provide more evidence regarding when, where, and in whom the sickle mutation arose.

Therein lies the problem for Carl Zimmer and others like him. When they find “…more evidence of when, where, and in whom the sickle mutation arose,” that evidence will be linked from the mutation to energy-dependent ecological adaptations by changes in the microRNA/messenger RNA balance and alterrnative splicings linked to amino acid substitutions and more than 1700 other hemoglobin variants.

See: Updates of the HbVar database of human hemoglobin variants and thalassemia mutations

Hemoglobinopathies are the commonest single-gene genetic disorders in humans, resulting from pathogenic genome variants in the human α-like and β-like globin gene clusters (reviewed in 1). Single nucleotide substitutions or indels [INsertions/DELetionS] can lead to several hemoglobin variants owing to amino acid replacements, while molecular defects in either regulatory or coding regions of the human HBA2, HBA1, HBB or HBD genes can minimally or drastically reduce their expression, leading to α-, β- or δ-thalassemia, respectively.

Clearly, the hemoglobin variants are food energy-dependent ecological adaptations and the adaptations can be compared to mutation-driven molecular defects manifested as the differences in the thallassemias.

See also:  How One Child’s Sickle Cell Mutation Helped Protect the World From Malaria by Carl Zimmer

…the protection afforded by a single copy of the sickle cell mutation against malaria kept fueling its spread.

Adaptations protect organized genomes from the virus-driven degradation of messenger RNA. Mutations link the virus-driven theft of quantized energy to all pathology.

See: Cytosis

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

Carl Zimmer may pretend not to know anything about biophysically constrained viral latency, but he recently announced the forthcoming publication of his book: She Has Her Mother’s Laugh: The Powers, Perversions, and Potential of Heredity

Excerpt from the book description:

We need a new definition of what heredity is and, through Carl Zimmer’s lucid exposition and storytelling, this resounding tour de force delivers it.

No one delivers a new definition of heredity without risking the attacks that will come from serious scientists. Serious scientists do not need to define haplotypes in the context of population genetics. So-called science journalists have been caught in their misrepresentations of how viral latency is biophysically constrained by what organisms eat and the physiology of pheromone-controlled reproduction in species from microbes to humans.

Any intelligent person who places the facts that Carl Zimmer placed into the context of the past 7300 years of evolution will arrive at the same conclusions that young earth creationists have touted about the difference between evolution and engineered energy-dependent adaptability.

See for instance: Engineered Adaptability: Creatures’ Adaptability Begins with Their Sensors

See also: Feedback loops link odor and pheromone signaling with reproduction

See also: Carl Zimmer refutes theistic evolution (2) (in prep)

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