Alternative Splicings

Separated we survive (2)

August 8, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated toxicity
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This was included in one of the four tweets that led Twitter to lock my account for violating Twitter Rules, which appear to be used to separate facts from theories in the context of Existential Physics. For an example of how polyphenols link food energy to prevention of virus-driven diseases, see: The emerging role of miRNAs in the pathogenesis of COVID-19: Protective effects of nutraceutical polyphenolic compounds against SARS-CoV-2 infection 7/18/22 I placed the facts about the 4 polyphenols into…

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Biophotonically charged life (10)

August 5, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
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Effective 8/5/22 “25% of Your Audience is From China” miRNAs (145,735 results) miRNA and china (70,734 results) Nearly half the results that link God’s energy-dependent Creation of the light-activated electron transport chain from miRNA biogenesis to biophysically constrained viral latency across kingdoms via fixation of amino acid substitutions in microtubules come from researchers in China. This suggests researchers from China probably do not believe in stupid theories about their evolution from pond scum. See for comparison of theories to facts…

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Biophotonically charged life (4)

July 24, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Subatomic, Variations
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Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells 7/23/15 and Pregnancy enables antibody protection against intracellular infection link biophotonically charged life from light-activated carbon fixation in cyanobacteria and fixation of amino acid substitutions in microtubules to biophysically constrained viral latency across kingdoms via this claim about the fine-tuning of energy-dependent ecological adaptations: Consideration of the maternal–fetal dyad as a joined immunological unit reveals protective roles for antibodies against intracellular infection and fine-tuned adaptations to enhance host defence during pregnancy and…

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Biophotonically charged life (3)

July 21, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA interference, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
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“…Joe Biden has tested positive for COVID-19 and is experiencing “mild symptoms,” White House press secretary Karine Jean-Pierre said on Thursday. Biden, who is fully vaccinated and twice boosted, has started taking Paxlovid, Pfizer’s antiviral drug used to minimize the severity of COVID-19.”  7/21/22 Paxlovid is a microtubule inhibitor. That fact links epigenetic effects of sunlight and humidity from the weakening of COVID19 to effective cancer treatments via Photocontrolling Microtubule Dynamics with Photoswitchable Chemical Reagents 4/28/22 and use of microtubule…

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Codon optimality vs systemic fraud (6)

July 2, 2022
James Kohl
Adaptations, Alternative Splicings, biophotonics, Ecology, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Re: Analysis of mRNA Dynamics Using RNA Sequencing Data 7/2/22 Excerpt 1) The RNA abundance of each gene is determined by its rates of transcription and RNA decay. Excerpt 2) Estimating differential transcription and decay rates of RNA molecules would enable the identification of regulatory factors, such as transcription factors, RNA binding proteins, and microRNAs, that govern large-scale shifts in RNA expression. Excerpt 3) We…demonstrate how estimates of differential stability can be leveraged to infer the regulatory factors underlying them.…

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Codon optimality vs systemic fraud (5)

June 27, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA interference, RNA–Mediated Epigenetic Heredity, Subatomic, Variations
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Light-Controlled Recruitable Hybridization Chain Reaction on Exosome Vehicles for Highly Sensitive MicroRNA Imaging in Living Cells 6/27/22 links more than 144,000 other publications that mention miRNAs from Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20 to patented therapeutic solutions that help to protect organized genomes from the virus-driven degradation of messenger RNA. See: Results of Search in PGPUB Production Database and specifically: Nutraceuticals for the prevention, inhibition, and treatment of SARS-CoV-2 and associated COVID-19 The fact that natural selection…

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Codon optimality vs systemic fraud (4)

June 24, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
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A good model predicts. See: From Fertilization to Adult Sexual Behavior (1996). In our section on molecular epigenetics we predicted that A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins 6/16/22 would be linked to food energy and pheromone-regulated genetic processes of reproduction across kingdoms. On 6/23/22, that fact was placed back into the context of stupid theories. See: Abracadabra, One Becomes Two: The Importance of Context in Viral −1 Programmed Ribosomal Frameshifting  Yeast and potentially mammalian cells,…

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Epistemic corruption (10)

May 26, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
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Biosynthesis of cyanobacterin, a paradigm for furanolide core structure assembly 5/26/22 Full functional evaluation of the recombinant key enzymes in vivo and in vitro, individually and in concert, provided in-depth mechanistic insights into a streamlined C–C bond-forming cascade that involves installation of compatible reactivity at seemingly unreactive Cα positions of amino acid precursors. Our work extends the biosynthetic and biocatalytic toolbox for γ-butyrolactone formation, provides a general paradigm for furanolide biosynthesis and sets the stage for their targeted discovery, biosynthetic…

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Epistemic corruption (8)

May 18, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA interference, RNA-mediated gene silencing, Subatomic, Variations, What's in the News
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What don’t you believe about these facts from 1910? I posted this video to Facebook one year ago, after a trip across the United States, which I chronicled in a series of other videos. Since then, “Cellulose” has linked fixation of amino acid substitutions to construction of the cell wall and microRNA-mediated protein folding chemistry via microRNA-mediated stem cell creation and healthy longevity across kingdoms. For examples of how energy-dependent ecological adaptations eliminate stupid theories about mutation-driven evolution, which link…

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Epistemic corruption (7)

May 17, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, replication timing, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
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NYU may hire biologist pushed out of MIT, Whitehead for sexual misconduct 4/25/22 “Civility Rules.” “A mob feels compelled to stridently ‘cancel’ someone with different thoughts, or to baselessly attack an individual in ways that can be difficult to disprove,” he wrote. “This is tolerated in academia, where nameless accusers can disparage a colleague’s science and life’s work, even when their claims are unfounded.” Grossman declined to comment further. Eric Lander, former science advisor to Joe Biden, became a victim…

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