Alternative Splicings

The tipping point (revisited): 110K (2)

October 22, 2020
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Neuronal Plasticity, Physics, RNA Directed, RNA interference
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Democrats seem to believe that President Trump’s claims about UV light and humidity have not been linked from the end of the COVID-19 nonsense to the end of their party, the end of Communism, the end of atheism, the end of racism and the end of all the liberal BS. Is the link from God’s Creation of UV light and water to ATP-dependent oxidative phosphorylation not perfectly clear to all intelligent people? See for review: From Fertilization to Adult Sexual…

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From optoribogenetics to HelioRiboGenetics (3)

October 6, 2020
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Physics, RNA interference
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See first: From optoribogenetics to HelioRiboGenetics (2) and From optoribogenetics to HelioRiboGenetics (1) “Opto” means light. “Helio” links God’s Creation of UV light to RNA-mediated protection from viruses across kingdoms via hydrogen-atom transfer in DNA base pairs in solution. Circulating microRNAs associated with liver fibrosis in chronic hepatitis C patients Chronic hepatitis C (CHC) evolves in 20% of cases to liver cirrhosis after progressive stages of fibrosis (Center for Diseases Control and Prevention – CDC, 2019). The most serious complication…

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From optoribogenetics to HelioRiboGenetics (2)

October 5, 2020
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, RNA Directed, RNA interference, RNA–Mediated Epigenetic Heredity
One Comment

See first: From optoribogenetics to HelioRiboGenetics (1) For consistency see Abcam’s: Spotlight on Neuroscience [and the 2020 Nobel Prize for Physiology or Medicine] Abcam’s forthcoming live sessions Adult Neurogenesis  Building and Reparing the Brain Epigenetics in the Nervous System On-demand webinars Role of chronic inflammation in risk for neurodegenerative disorders: Alzheimer’s disease Autophagy and Neurodegeneration Chronic virus-driven inflammation perturbs epigenetic effects on energy-dependent microRNA-mediated autophagy, which prevents neurodegeneration. Attempts to discredit Judy A. MIkovits for her role in linking God’s…

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From optoribogenetics to HelioRiboGenetics (1)

October 5, 2020
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA interference
2 Comments

Optoribogenetic control of regulatory RNA molecules 9/24/20 “Opto” means light. “Helio” links God’s Creation of UV light to RNA-mediated protection from viruses across kingdoms via hydrogen-atom transfer in DNA base pairs in solution. Had he lived, Bruce S. McEwen probably would have received the 2020 Nobel Prize in Physiology or Medicine for linking God’s Creation of UV light and water from energy-as-information to biophysically constrained viral latency across kingdoms. McEwen et al., (1964) linked that heliocentric approach to scientific creationism…

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Optoribogenetic-driven sympatric speciation (1)

September 30, 2020
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
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For presentation during session: Polycomb and chromatin remodeling Historical perspective: Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes… Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at…

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UV light, H2O, and epigenetic effects… (1)

September 25, 2020
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Physics, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
One Comment

See first: Coherently organized healthy longevity (4) UV light, H2O, and epigenetic effects affect behavior and sympatric speciation Submitted by James V. Kohl on 9/25/20 for presentation during the Epigenetics – From Bench to Clinic session: RNA modifications and epitranscriptomics​​ Moderator Tony Kouzarides Title: UV light, H2O, and epigenetic effects affect behavior and sympatric speciation James V. Kohl* MicroRNA.pro Introduction UV light-activated, H2O-dependent oxidative phosphorylation links microRNA-mediated epigenetic effects on organized genomes from bench to clinic.  For a historical perspective,…

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Coherently organized healthy longevity (4)

September 25, 2020
James Kohl
Alternative Splicings, Autophagy, base editing, RNA Directed
No Comments

See first: Coherently organized healthy longevity (3) “Perfect Pairing” prevents cancer and all other forms of virus-driven pathology. Biologically uninformed science idiots have placed everything known to serious scientists about biophysically constrained “perfect pairing,”microRNA-mediated viral latency, and healthy longevity into the context of computational biology and chemistry via theoretical pairing. See their ridiculous claim in Computational prediction of miRNA/mRNA duplexomes at the whole human genome scale reveals functional subnetworks of interacting genes with embedded miRNA annealing motifs …a very large…

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The microRNA-mediated fight against COVID-19 (1)

August 21, 2020
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, RNA interference, What's in the News
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History (1) Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013) …the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. History (2) Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (2014 unpublished) This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino…

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Coherently organized healthy longevity (1)

July 31, 2020
James Kohl
Alternative Splicings, Cytosis, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA interference, What's in the News
One Comment

A large-scale binding and functional map of human RNA-binding proteins [RBPs] 7/29/20 We describe the spectrum of RBP binding throughout the transcriptome and the connections between these interactions and various aspects of RNA biology, including RNA stability, splicing regulation and RNA localization. These data expand the catalogue of functional elements encoded in the human genome by the addition of a large set of elements that function at the RNA level by interacting with RBPs. Reported as: ENCODE consortium identifies RNA…

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pH-dependent healthy longevity (1)

June 19, 2020
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Physics, RNA Directed, RNA interference, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
No Comments

Who else linked pH-dependent viral latency to pH-dependent healthy longevity via the Korean Genome Project‘s ethnicity-specific reference genome sequences? The facts about energy-dependent microRNA-mediated biophysically constrained viral latency can be compared to ridiculous theories from the gene-centric Human Genome Project touted by NIH Director, Francis S. Collins. Other neo-Darwinian theorists also failed to start with facts about God’s Creation of UV light and water, which Charles Darwin included in his energy-dependent “conditions of life” Darwin’s “conditions of life” presciently linked…

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