Alternative Splicings

Predicting the CRISPR Cas9 Market Collapse

Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo Knowing that nucleosomes interfere directly with Cas9 cleavage, but not with ZFN cleavage, is useful information. It may explain some cases of unanticipated sgRNA failure, and it should guide specific applications where precisely located, high-efficiency cleavage is necessary. Reported as: CRISPR’s hedgehog problem: Rolled-up genes can’t be Predicting the CRISPR Cas9 Market Collapse

Info Wars: From hate-monger PZ Myers to Kevin J. Mitchell

The spurious claim that microRNAs evolved independently ignores all the facts that link natural selection for quantized energy-dependent codon optimality from differences in RNA sequencing and differences in transcriptome assembly to differences in the amino acid sequence of genes. Summary of Info Wars: Hate-monger PZ Myers on the Origin of Life (3)  …any type of Info Wars: From hate-monger PZ Myers to Kevin J. Mitchell

Molecular Grammar: Editing the Language of God (2)

Competition for funding continues to bastardize the claims of serious scientists. Pseudoscientists will do anything to get paid. But they refuse to learn how the creation of the sun’s anti-entropic virucidal energy links microRNA biogenesis to viral latency and all biophysically constrained biodiversity. Compare the claims from What’s new for ‘microRNA‘ in PubMed to the Molecular Grammar: Editing the Language of God (2)

Facebook community standards?

Excerpt: For comparison see: Death of new microRNA genes in Drosophila via gradual loss of fitness advantages The life and death of all organisms and all species is quantized energy-dependent and microRNA-mediated in the context of microRNA biogenesis that biophysically constrains viral latency. Facebook Suspends Alex Jones for 30 Days for “Bullying” and “Hate Speech” Facebook community standards?

MicroRNA-mediated feedback loops (5)

Breath Test Device Could Help Diagnose Early-Stage Parkinson’s Disease Researchers from Israel have linked the metabolism of food to pheromones and they are using breath analysis to help diagnose Parkinson’s as if they were testing for alcohol abuse. This suggests they will use human pheromones to biophysically constrain the virus-driven degradation of messenger RNA that MicroRNA-mediated feedback loops (5)

MicroRNA-mediated feedback loops (4)

Photomodulation links light-activated microRNA biogenesis to RNA-mediated DNA repair in the context of the cell biology game “Cytosis” biomodulation of feedback loops,  and in the context of Biblical Genesis. See for examples: photobiomodulation RNA Photobiomodulation prevents DNA fragmentation of alveolar epithelial cells and alters the mRNA levels of caspase 3 and Bcl-2 genes in acute MicroRNA-mediated feedback loops (4)

MicroRNA-mediated feedback loops (3)

DNA Methylation: Timekeeper of Biological Age Cellular senescence, telomere shortening, and changes in gene expression have been well documented to contribute to the aging process. Recently, researchers have found that epigenetic changes, such as the presence of methyl groups in close proximity to CpG dinucleotides located near a gene’s promoter, correlate with age. Technological advances, MicroRNA-mediated feedback loops (3)