Alternative Splicings

The stability of organized genomes (2)

See also: The stability of organized genomes See also: The amino acid transporter SLC6A15 is a regulator of hippocampal neurochemistry and behavior Excerpt: Despite the high heritability of depression and a clear genetic contribution to the disease, the identification of genetic risk factors for depression has been very difficult. The first published candidate to reach genome-wide significance in depression was SLC6A15, a neuronal amino acid transporter. With a reported 1,42 fold increased risk of suffering from depression associated with a…

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Is the best Chinese research from China?

8 and great: the best Chinese research of 2015 in Genome Biology Excerpt 1) They found that the relationship between mRNA and protein levels is increasingly unlinked during aging. This occurrence is likely caused by modifications to the mRNA that alter stability, or prevent translation into proteins. Many of the genes that were predicted to be targeted for these modifications are known to be involved in lifespan extension, mitochondrial function, and Alzheimer’s disease. My comment: The modifications to the mRNA…

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Neo-Darwinian theory is for the birds

The amino acid transporter SLC6A15 is a regulator of hippocampal neurochemistry and behavior Excerpt: Despite the high heritability of depression and a clear genetic contribution to the disease, the identification of genetic risk factors for depression has been very difficult. The first published candidate to reach genome-wide significance in depression was SLC6A15, a neuronal amino acid transporter. With a reported 1,42 fold increased risk of suffering from depression associated with a single nucleotide polymorphism (SNP) in a regulatory region of…

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The stability of organized genomes

Beyond neo-Darwinism—an epigenetic approach to evolution Excerpt from 6/21/79 The evidence suggests… that a relative lack of natural selection may be the prerequisite for major evolutionary advance. Nutrient-dependent/pheromone-controlled adaptive evolution: a model. Excerpt from 6/14/13 (34 years later) …the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive…

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Viruses, amino acids, and somatic cell types (3)

A co-author of our 1996 Hormones and Behavior review of hormone-organized and hormone-activated behaviors gave her permission to add additional items of interest to this series of blog posts about viruses, amino acids, and somatic cell types. Teresa Binstock is largely responsible for my knowledge of RNA-mediated cell type differentiation. She introduced me and others to the complexity in the section of our review with the title Molecular epigenetics. Excerpt: It is now understood that certain genes undergo a process…

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Viruses, amino acids, and somatic cell types (2)

Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain Excerpt: The RNA-seq data enabled us to detect a positive correlation between developmental changes in the magnitude of parental biases and overall gene expression for most imprinted genes. Conclusion: At the level of the organism, our data uncover how paternal and maternal alleles of Bcl-x make vastly different contributions to brain development, a result that has profound implications for the analysis of parentally-inherited polymorphisms in human health. Reported…

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Viruses, amino acids, and somatic cell types

Although the ultimate origins of RNA viruses are uncertain, it seems reasonable to assume that these infectious agents have a long evolutionary history, appearing with, or perhaps before, the first cellular life-forms (38). The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis… Perhaps the evolutionists have placed the cart before the horse on this issue, as proposed by several…

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Domestication via a single amino acid substitution

Evidence That the Origin of Naked Kernels During Maize Domestication Was Caused by a Single Amino Acid Substitution in tga1 Excerpt: “Our molecular and genetic analyses of tga1 show how a simple amino acid change can alter protein function and thereby drive the evolution of a new phenotypic state.” Reported as: Study shows how a kernel got naked and corn became king Excerpt: The answer often lies in mutations, the currency of evolution. Sometimes single letters are changed in the…

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Koonin: viruses killed neo-Darwinism

The environmental influence on epigenetics Excerpt:  Let the (informed) debate begin. My comment: Informed debate is not possible in the ScienceX venue. See for comparison: Riding the Evolution Paradigm Shift With Eugene Koonin Excerpt: “…the new understanding of evolution needs to integrate what we now know about viruses and virus-host interactions which, from my own perspective, has been absolutely one of the key factors of all evolution since the emergence of cells — well, actually even before the emergence of…

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RNA-mediated morphological AND behavioral phenotypes

The New Genetics and Natural versus Artificial Genetic Modification Excerpt: In order to survive, the organism needs to engage in natural genetic modification in real time, an exquisitely precise molecular dance of life with RNA and DNA responding to and participating in “downstream” biological functions. My comment:RNA-mediated gene duplications and fixation of RNA-mediated amino acid substitutions link the honeybee model organism of nutrient-dependent pheromone-controlled morphological and behavioral phenotypes to cell type differentiation and biodiversity of all vertebrates. That is why…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]