Alternative Splicings

Screaming viruses and Alzheimer’s (1)

Summary: The future of biology limits claims about mutation-driven evolution to examples of what Richard Feynman referred to as human idiocy (video) in the context of theoretical physicists’ different measures of what happens to the quantized energy that is biophysically constrained in the food organisms eat. Co-evolution,  amino acid mutation, interacting proteins, protein homology modelling, Screaming viruses and Alzheimer’s (1)

Quantized energy-dependent biogenesis of circRNAs

circular RNA, microRNA, non-coding RNA, Cancer, biomarker, Epigenetic, Biophysics, Ecology, Variant, Constraint, Adaptation, Vitamin, Nutrient, Species Diversity See: Building one molecule from a reservoir of two atoms Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (2018) Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems  (2014) What will the children and grandchildren of biologically uninformed theorists Quantized energy-dependent biogenesis of circRNAs

MicroRNA biogenesis, the microRNAome, and your brainome

The Scent of Eros

Conclusion: By the time the most brilliant minds present their works on energy-dependent life, there will be more than 75,000 published works that link quantized energy-dependent microRNA biogenesis to biophysically constrained viral latency. The same published works (1000 for each year) link the theories of pseudoscientists to all pathology. Circular RNAs in Cancer – Lessons MicroRNA biogenesis, the microRNAome, and your brainome

Estranged ‘White Coat Notes’ blogger exposes human idiocy (2)

Conclusion: …there are constraints on the mixed state entanglement… The biophysical constraints attest to the fact that quantum entanglement in photosynthetic complexes does not evolve. The works of two people who recently became members of the RNA-mediated FaceBook group attest to the overwhelming ignorance of biologically uninformed theorists. See for example: The C. elegans hunchback Estranged ‘White Coat Notes’ blogger exposes human idiocy (2)

NHEJ disruption and HDR correction?

International Workshop “Targeting RNA world” Dear colleagues! Scientists of the Institute of Chemical Biology and Fundamental Medicine SB RAS cordially invites you to attend International Workshop “Targeting RNA world” in the frame of the project of Russian Scientific Foundation “New generation of RNA-targeting oligonucleotide derivatives as a platform for designing innovative therapeutics” (no. 14-44-00068). Workshop NHEJ disruption and HDR correction?

MicroRNA abundance, activity, and specificity

International Workshop “Targeting RNA world” Dear colleagues! Scientists of the Institute of Chemical Biology and Fundamental Medicine SB RAS cordially invites you to attend International Workshop “Targeting RNA world” in the frame of the project of Russian Scientific Foundation “New generation of RNA-targeting oligonucleotide derivatives as a platform for designing innovative therapeutics” (no. 14-44-00068). Workshop MicroRNA abundance, activity, and specificity

Virus-driven genome engineering causes cancer?

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response Inhibition of p53 prevents the damage response and increases the rate of homologous recombination… In the 1990’s, Abcam researchers discovered the cell death gene. Now see: Mechanisms of Recombination conference See also: P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem Virus-driven genome engineering causes cancer?