Alternative Splicings

UV light, H2O, and epigenetic effects… (4)

Before submitting your scientific manuscript for peer review, ensure that your results are reproducible by rigorously validating reagents such as antibodies. 9/29/2020 Find out how: Knockout validation: Overcoming the perils of poor antibody specificity Also, remember to link God’s Creation of UV light and water from oxidative phosphorylation and helioribogenetics to biophysically constrained viral latency across kingdoms via the physiology of pheromone-regulated genetic processes, or you will be referred to as a “theorist.” The theorists are stuck with a failed…

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Election day blues for fools who “voted blue” (2)

See first: Election day blues for fools who “voted blue” (1) Perhaps the biggest problem for Democrats, liberals, Communists and other atheists is that they cannot see the UV light and do not believe it is God’s example of what is there. Hydrogen ions are there. Start with that fact to link them from God’s Creation of energy to the potential of hydrogen (pH) and link changes in pH to peptide-dependent life via the physiology of reproduction and protonated RNA…

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Protonated RNA interference vs stupid theories (5)

See first: Protonated RNA interference vs stupid theories (4) See with my emphasis The noncoding and coding transcriptional landscape of the peripheral immune response in patients with COVID‐19 10/11/20 Noncoding RNAs (ncRNAs) are a class of RNAs not involved in protein production and can be subdivided into small (miRNAs, tRNAs, PIWI‐targeting RNAs) and long ncRNAs (lncRNAs), based upon their size.8 This class of RNAs not only regulates fundamental biological processes including immune system development and regulation, but also plays a…

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Protonated RNA interference vs stupid theories (2)

Protonated RNA interference vs stupid theories (1) Evidence for Hidden Involvement of N3-Protonated Guanine in RNA Structure and Function 1/31/19 Charged nucleobases have been found to occur in several known RNA molecules and are considered essential for their structure and function. Estimating Strengths of Individual Hydrogen Bonds in RNA Base Pairs: Toward a Consensus between Different Computational Approaches 4/30/19 Noncoding RNA molecules are composed of a large variety of noncanonical base pairs that shape up their functionally competent folded structures.…

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Protonated RNA interference vs stupid theories (1)

Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20 …microRNA maturation efficiency may be encoded in the intrinsic dynamic ensemble of primary and precursor microRNAs, providing a potential means of regulating microRNA biogenesis in response to environmental and cellular stimuli. See for comparison:  The landscape of host genetic factors involved in immune response to common viral infections 10/27/20 Humans and viruses have co-evolved for millennia resulting in a complex host genetic architecture. Understanding the genetic mechanisms of immune response…

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microRNA-mediated quantum error correction (4)

I’ve posted presentation abstract submissions here because I anticipated they would not be selected for presentation. See: UV light, H2O, and epigenetic effects… (1) 9/25/20 Submitted by James V. Kohl on 9/25/20 for presentation during the Epigenetics – From Bench to Clinic session: RNA modifications and epitranscriptomics​​ Moderator Tony Kouzarides Conclusion: Theorists who ignore the role of nutrition in biophysically constrained viral latency are largely to blame for all extant diseases. 21 See for instance: The Secret Language of Cells:…

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microRNA-mediated quantum error correction (3)

See: microRNA-mediated quantum error correction (1) On 10/19/20, more than 250 additions to the indexed articles that mention the term ‘microRNA’ appeared after 5 days of what appeared to be a moratorium linked to publication of Thousands of Previously Unknown Phages Discovered in Whole-community Human Gut Metagenomes on 10/14/20. See also: Before Virus, After Virus: A Reckoning 10/15/20 The pandemic has energized us, yes, but it has also provided a necessary dose of humility. It has also been a call…

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The tipping point (revisited): 110K (2)

Democrats seem to believe that President Trump’s claims about UV light and humidity have not been linked from the end of the COVID-19 nonsense to the end of their party, the end of Communism, the end of atheism, the end of racism and the end of all the liberal BS. Is the link from God’s Creation of UV light and water to ATP-dependent oxidative phosphorylation not perfectly clear to all intelligent people? See for review: From Fertilization to Adult Sexual…

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From optoribogenetics to HelioRiboGenetics (3)

See first: From optoribogenetics to HelioRiboGenetics (2) and From optoribogenetics to HelioRiboGenetics (1) “Opto” means light. “Helio” links God’s Creation of UV light to RNA-mediated protection from viruses across kingdoms via hydrogen-atom transfer in DNA base pairs in solution. Circulating microRNAs associated with liver fibrosis in chronic hepatitis C patients Chronic hepatitis C (CHC) evolves in 20% of cases to liver cirrhosis after progressive stages of fibrosis (Center for Diseases Control and Prevention – CDC, 2019). The most serious complication…

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From optoribogenetics to HelioRiboGenetics (2)

See first: From optoribogenetics to HelioRiboGenetics (1) For consistency see Abcam’s: Spotlight on Neuroscience [and the 2020 Nobel Prize for Physiology or Medicine] Abcam’s forthcoming live sessions Adult Neurogenesis  Building and Reparing the Brain Epigenetics in the Nervous System On-demand webinars Role of chronic inflammation in risk for neurodegenerative disorders: Alzheimer’s disease Autophagy and Neurodegeneration Chronic virus-driven inflammation perturbs epigenetic effects on energy-dependent microRNA-mediated autophagy, which prevents neurodegeneration. Attempts to discredit Judy A. MIkovits for her role in linking God’s…

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