Autophagy

Hypothesis free pseudoscience vs facts (4)

See first Hypothesis free pseudoscience vs facts (3) See also: The terrorist inside my husband’s brain Conclusion: I know you have accomplished much already in the areas of research and discovery toward cures in brain disease. And I am sure at times the progress has felt painfully slow. Do not give up. Trust that a cascade of cures and discovery is imminent in all areas of brain disease and you will be a part of making that happen. If only…

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Selective reporting of inferences: examples of pseudoscience

In the narrative of this presentation on RNA mediated molecular epigenetics and virus driven entropy, I mentioned that Cori Bargmann is scheduled to deliver a lecture entitled “Genes, neurons, circuits and behavior: an integrated approach in a compact brain.” An integrated approach will help others understand what is currently known about how ecological variation leads to ecological adaptation. Works, like hers, with the nematode model organism will help others understand how ecological adaptation leads to biodiversity in the morphological phenotypes…

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RNA-mediated repurposing in microbes and adaptations in primate brains

Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion Excerpt: “…the C-terminal 47 amino-acids of ARHGAP11B (after lysine-220) constitute not only a unique sequence, resulting from a frameshifting deletion (fig. S10), but also are functionally distinct from their counterpart in ARHGAP11A.” My comment: Co-author Svante Paabo is the senior author of this 2003 publication: Natural Selection on the Olfactory Receptor Gene Family in Humans and Chimpanzees The 2015 publication was reported as: A gene for brain size only found…

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RNA-mediated “repurposing” is nutrient-dependent and pheromone-controlled

 Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system Excerpt: The fast-spreading strain AR2F had acquired an additional point mutation in the σ54-dependent EBP gene ntrC, which alters an amino acid (R442C) within the DNA binding domain (Table 1 and table S2). Reported as: Evolutionary Rewiring Strong selective pressure can lead to rapid and reproducible evolution in bacteria. By Ruth Williams | February 26, 2015 Excerpt: NtrC shares 30 percent amino acid identity with FleQ, suggesting the…

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Biophysically constrained beginnings of RNA and DNA

Any anonymous participant in the discussion of: DNA may have had humble beginnings as nutrient carrier (Sep 01, 2014 by Adam Hadhazy) asks: “when are you going to keep quiet?” In a series of responses, I have explained the problem I have with honoring his request. The following excerpts from Wikipedia and other sources are loosely strung together because there is no point to providing more extensive details of biologically-based cause and effect until others accept the fact that mutations…

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