base editing

The tipping point (revisited): 110K (2)

Democrats seem to believe that President Trump’s claims about UV light and humidity have not been linked from the end of the COVID-19 nonsense to the end of their party, the end of Communism, the end of atheism, the end of racism and the end of all the liberal BS. Is the link from God’s Creation of UV light and water to ATP-dependent oxidative phosphorylation not perfectly clear to all intelligent people? See for review: From Fertilization to Adult Sexual…

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microRNA-mediated quantum error correction (2)

What Fans of ‘Herd Immunity’ Don’t Tell You 10/19/20 …the White House has all but embraced herd immunity and has also poisoned the public with misinformation, making it all but impossible to get national, near-universal compliance with public health advice for the foreseeable future. Herd immunity exemplifies nutrient-dependent pheromone-controlled ecological adaptations, which annoys neo-Darwinian theorists and Big Bang cosmologists, especially those who also are Trump-haters. See for comparison: Robust Filtering and Noise Suppression in Intragenic miRNA-Mediated Host Regulation 9/21/20 Specifically,…

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From optoribogenetics to HelioRiboGenetics (7)

Charting a Coronavirus Infection 10/5/20 “After months of downplaying the threat of the Covid-19 pandemic, President Trump…” …was vindicated when Roger Penrose won a Nobel Prize in Physics on October 6, 2020.  In 1991, Penrose indirectly linked food energy from quantum coherence to coherently organized biology via God’s claims in Biblical Genesis. See: What is Life?: With Mind and Matter and Autobiographical Sketches (Canto Classics) Reprint Edition by Erwin Schrodinger/Penrose (Author) How often do we still hear that quantum effects…

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From optoribogenetics to HelioRiboGenetics (3)

See first: From optoribogenetics to HelioRiboGenetics (2) and From optoribogenetics to HelioRiboGenetics (1) “Opto” means light. “Helio” links God’s Creation of UV light to RNA-mediated protection from viruses across kingdoms via hydrogen-atom transfer in DNA base pairs in solution. Circulating microRNAs associated with liver fibrosis in chronic hepatitis C patients Chronic hepatitis C (CHC) evolves in 20% of cases to liver cirrhosis after progressive stages of fibrosis (Center for Diseases Control and Prevention – CDC, 2019). The most serious complication…

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From optoribogenetics to HelioRiboGenetics (2)

See first: From optoribogenetics to HelioRiboGenetics (1) For consistency see Abcam’s: Spotlight on Neuroscience [and the 2020 Nobel Prize for Physiology or Medicine] Abcam’s forthcoming live sessions Adult Neurogenesis  Building and Reparing the Brain Epigenetics in the Nervous System On-demand webinars Role of chronic inflammation in risk for neurodegenerative disorders: Alzheimer’s disease Autophagy and Neurodegeneration Chronic virus-driven inflammation perturbs epigenetic effects on energy-dependent microRNA-mediated autophagy, which prevents neurodegeneration. Attempts to discredit Judy A. MIkovits for her role in linking God’s…

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From optoribogenetics to HelioRiboGenetics (1)

Optoribogenetic control of regulatory RNA molecules 9/24/20 “Opto” means light. “Helio” links God’s Creation of UV light to RNA-mediated protection from viruses across kingdoms via hydrogen-atom transfer in DNA base pairs in solution. Had he lived, Bruce S. McEwen probably would have received the 2020 Nobel Prize in Physiology or Medicine for linking God’s Creation of UV light and water from energy-as-information to biophysically constrained viral latency across kingdoms. McEwen et al., (1964) linked that heliocentric approach to scientific creationism…

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UV light, H2O, and epigenetic effects… (1)

See first: Coherently organized healthy longevity (4) UV light, H2O, and epigenetic effects affect behavior and sympatric speciation Submitted by James V. Kohl on 9/25/20 for presentation during the Epigenetics – From Bench to Clinic session: RNA modifications and epitranscriptomics​​ Moderator Tony Kouzarides Title: UV light, H2O, and epigenetic effects affect behavior and sympatric speciation James V. Kohl* MicroRNA.pro Introduction UV light-activated, H2O-dependent oxidative phosphorylation links microRNA-mediated epigenetic effects on organized genomes from bench to clinic.  For a historical perspective,…

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Coherently organized healthy longevity (4)

See first: Coherently organized healthy longevity (3) “Perfect Pairing” prevents cancer and all other forms of virus-driven pathology. Biologically uninformed science idiots have placed everything known to serious scientists about biophysically constrained “perfect pairing,”microRNA-mediated viral latency, and healthy longevity into the context of computational biology and chemistry via theoretical pairing. See their ridiculous claim in Computational prediction of miRNA/mRNA duplexomes at the whole human genome scale reveals functional subnetworks of interacting genes with embedded miRNA annealing motifs …a very large…

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Coherently organized healthy longevity (3)

  Development of MicroRNAs as Potential Therapeutics against Cancer 7/15/20 The perfect pairing of the miRNA with the target mRNA promotes mRNA degradation, while imperfect base pairing will lead to protein translational repression. God’s UV light-activated “Perfect Pairing” prevents cancer and all other forms of virus-driven pathology. See: Light-mediated strong coupling between a mechanical oscillator and atomic spins 1 meter apart 5/10/20 To achieve quantum-coherent coupling (40), g must also exceed all thermal and quantum back-action decoherence rates. This is…

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The microRNA-mediated fight against COVID-19 (1)

History (1) Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013) …the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. History (2) Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (2014 unpublished) This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino…

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