base editing

Codon optimality vs systemic fraud (4)

A good model predicts. See: From Fertilization to Adult Sexual Behavior (1996). In our section on molecular epigenetics we predicted that A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins 6/16/22 would be linked to food energy and pheromone-regulated genetic processes of reproduction across kingdoms. On 6/23/22, that fact was placed back into the context of stupid theories. See: Abracadabra, One Becomes Two: The Importance of Context in Viral −1 Programmed Ribosomal Frameshifting  Yeast and potentially mammalian cells,…

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Codon optimality vs systemic fraud (3)

A system of fraud exists that fails to link natural selection for energy-dependent codon optimality to The Association between Single Nucleotide Polymorphisms, including miR-499a Genetic Variants, and Dyslipidemia in Subjects Treated with Pharmacological or Phytochemical Lipid-Lowering Agents 5/17/22 This article belongs to the Special Issue Molecular Effects of Phytochemicals on Cholesterol Metabolism Genes Collectively, everything known to intelligent serious scientists about cell type differentiation across kingdoms can be linked from An Expanded Landscape of Unusually Short RNAs in 11 Samples…

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Codon optimality vs systemic fraud (2)

See first: Codon optimality vs systemic fraud (1) Researchers identified over 5,500 new viruses in the ocean, including a missing link in viral evolution 4/8/22 and Ocean water samples yield treasure trove of RNA virus data 4/8/22 attest to facts about the Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20 that link God’s ATP-dependent Creation of RNA from RNA-peptide interactions at the origin of life to the Mapping and characterization of structural variation in 17,795…

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Codon optimality vs systemic fraud (1)

Two summaries of neo-Darwinian evolutionary theory: Amino acid composition of proteins varies substantially between taxa and, thus, can evolve. …yeast receptors trigger activation of heterotrimeric G proteins just as mammalian receptors do, this conserved signaling pathway must have been present in the common ancestor of yeast and humans. Unless you are a biologically uninformed theorist, see first Epistemic corruption (10) Watch for my next 10-part series on Codon optimality vs systemic fraud. I will link it to the fraudulent representations…

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Epistemic corruption (10)

Biosynthesis of cyanobacterin, a paradigm for furanolide core structure assembly 5/26/22 Full functional evaluation of the recombinant key enzymes in vivo and in vitro, individually and in concert, provided in-depth mechanistic insights into a streamlined C–C bond-forming cascade that involves installation of compatible reactivity at seemingly unreactive Cα positions of amino acid precursors. Our work extends the biosynthetic and biocatalytic toolbox for γ-butyrolactone formation, provides a general paradigm for furanolide biosynthesis and sets the stage for their targeted discovery, biosynthetic…

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Epistemic corruption (8)

What don’t you believe about these facts from 1910? I posted this video to Facebook one year ago, after a trip across the United States, which I chronicled in a series of other videos. Since then, “Cellulose” has linked fixation of amino acid substitutions to construction of the cell wall and microRNA-mediated protein folding chemistry via microRNA-mediated stem cell creation and healthy longevity across kingdoms. For examples of how energy-dependent ecological adaptations eliminate stupid theories about mutation-driven evolution, which link…

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Epistemic corruption (7)

NYU may hire biologist pushed out of MIT, Whitehead for sexual misconduct 4/25/22 “Civility Rules.” “A mob feels compelled to stridently ‘cancel’ someone with different thoughts, or to baselessly attack an individual in ways that can be difficult to disprove,” he wrote. “This is tolerated in academia, where nameless accusers can disparage a colleague’s science and life’s work, even when their claims are unfounded.” Grossman declined to comment further. Eric Lander, former science advisor to Joe Biden, became a victim…

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Epistemic corruption (6)

Summary: The rapid pace of experimental evidence linked to Selective MicroRNA-Offset RNA Expression in Human Embryonic Stem Cells 3/30/15 can be compared to the nonsense touted by neo-Darwinian theorists published as Shining Light on the Evolution of Photosynthesis 12/1/03 Photosynthetic bacteria and eukaryotes collect light energy for photosynthesis in structures called light-harvesting antenna complexes. Unless the light-harvesting complexes automagically created themselves, the facts about God’s Creation of sunlight link light-activated carbon fixation in cyanobacteria to pH-dependent microRNA-mediated protein folding chemistry,…

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Epistemic corruption (5)

This is a false claim Bacterial species rarely work together  5/5/22 See this placard from the US Department of the Interior’s National Park Service for comparison: Cyanobacteria were once called blue-green algae. Light-activated carbon fixation in cyanobacteria links their color from microRNA-mediated protein folding chemistry to protection from the virus-driven degradation of messenger RNA (mRNA). The protection of organized genomes from viruses has been linked to constraints on all virus-driven pathology across kingdoms via this patent for RNA interference, which…

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MicroRNA-mediated existential threats (8)

Summary: Natural processes link light-activated microRNA biogenesis to pH-dependent prevention of viral infections. The natural processes are energy-dependent and biophysically constrained by the pheromone-regulated genetic processes of reproduction across kingdoms from microbes to humans. Follow me @microRNApro on Twitter if you want to help others prevent virus-driven existential threats to humanity. See also: MicroRNA.pro, http://Autophagy.pro & continue to follow me on http://RNA-mediated.com as I link God’s Creation of subatomic particles from pH-dependent peptide synthesis to sympatric speciation and healthy ecosystems…

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