base editing

Light energy-induced base pair changes (2)

See: Light energy-induced base pair changes (1) To help others move forward via the concept of energy-dependent biophysically constrained RNA-mediated protein folding and what is known about how virus-driven energy theft is linked to all pathology, see also: Subatomic Particles, Part 1: Leptons Subatomic Particles, Part 2: Baryons, the Substance of the Cosmos Subatomic Particles, Part 3: Mesons If you are not ready to start from the de novo creation of the energy in a hydrogen atom, you may need…

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Hydrogen-Atom Transfer in DNA Base Pairs (4)

Historical perspective: Behold James Vaughn Kohl. Ecological adaptation occurs via the epigenetic effects of nutrients on alternative splicings of pre-mRNA which result in amino acid substitutions that differentiate all cell types of all individuals of all species. The control of the differences in cell types occurs via the metabolism of the nutrients to chemical signals that control the physiology of reproduction. These facts do not refute evolution; they simply refute the ridiculous theory of mutation-initiated natural selection that most people…

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Finding peace and π in the light of H bond energy

It might be amusing if the misrepresentations of links between energy and cell type differentiation by people like PZ Myers were not going to cause more suffering and death.  Instead, two years after his attack on me for my accurate representations of the link from nutrient energy-dependent chromosomal rearrangements to pheromone-controlled biodiversity in species from microbes to humans we see this: You’re trying to explain a random phenotype by looking for a randomization mechanism in the genome. No one will…

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Easy editing: Reinventing our RNA world

Easy DNA Editing Will Remake the World. Buckle Up. Excerpt: Most present-day animals and plants defend themselves against viruses with structures made out of RNA. My comment: RNA-mediated gene duplication and fixation of  RNA-mediated amino acid substitutions in the context of the nutrient-dependent physiology of learning, memory, and reproduction links the biophysically constrained chemistry of cell type differentiation in all genera via conserved molecular mechanisms. That fact was integrated into the science fiction novel Blood Music by Greg Bear, who…

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Pheromones and RNA-mediated events (A)

This is the output from my current Endnote Library of citations by authors where the first author’s last name begins with an A Abbasi, K. (2007). The smell of false hope. J R Soc Med., 100(6), 251. Abend, P., Pflüger, L. S., Koppensteiner, M., Coquerelle, M., & Grammer, K. The sound of female shape: a redundant signal of vocal and facial attractiveness. Evolution and Human Behavior(0). doi: http://dx.doi.org/10.1016/j.evolhumbehav.2014.10.004 Abi-Rached, J. M., & Rose, N. (2010). The birth of the neuromolecular…

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Let there be anti-entropic light (1)

Summary: Light-induced amino acid substitutions link cell type differentiation in plants to nutrient-dependent pheromone-controlled reproduction in animals via the biophysically constrained chemistry of protein folding. Protein folding is perturbed by mutations that limit the ability of organisms to adapt to ecological variation. Viruses contribute to mutations. The sun’s biological energy appears to supply the anti-entropic force that links entropic elasticity to the development of successful morphological and behavioral phenotypes that are exemplified in extant versus extinct biodiversity. The importance of…

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RNA-protein interactions reveal biophysical to ecological landscapes

Quantitative analysis of RNA-protein interactions on a massively parallel array reveals biophysical and evolutionary landscapes RNA-protein interactions are tethered to DNA via ultra-high-throughput measurement of the RNA-protein interactions that link amino acid substitutions to cell type differentiation. Differences in affinity are often driven by sequence-specific changes in both association and dissociation rates that rapidly link bio-physical constrained RNA-mediated protein folding to models that provide “…generalizable insight into the biophysical basis and evolutionary consequences of sequence-function relationships.” This is the generalizable…

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