base editing

Who created your virus-driven death gene? (3)

Summary: Students in the United States can learn how pseudoscientists bastardized Darwin’s theory by playing the game “Cytosis.” It links the creation of virucidal light to the creation of ATP and the creation of RNA, which biophysically constrains all energy-dependent biodiversity in the context of the physiology of pheromone-controlled reproduction. See for comparison: Male Flies Find a Mate With Wedding Gifts Made of Vomit and Weird Dancing When researchers artificially activated the fruitless circuitry with light, the flies were compelled…

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Who created your virus-driven death gene? (2)

Evolution of Constrained Gonadotropin-releasing Hormone Ligand Conformation and Receptor Selectivity These findings indicate that the substitution of glycine for a chiral amino acid in GnRH during evolution allows a more constrained conformation for receptor binding and that this subtle single amino acid substitution in a site remote from the ligand functional domains has marked effects on its structure and activity. The difference between an energy-dependent RNA-mediated amino acid substitution and a mutation has been largely ignored as pseudoscientists linked accidents…

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Mouse morphs and primate diversity in 50 years

Excerpt: Analysis of the crystal structure of deer mouse Hb at 1.8 Å resolution (24, 25) revealed that each of the eight rHb mutants is characterized by a unique constellation of hydrogen bonds within and between subunits (Table 2 and fig. S2). Additional hydrogen bonds between subunits of the same αβ dimer are formed in the presence of β128Ser (an L-type residue; fig. S2), which contributes to the observed epistasis between allelic α- and β-chain variants. ——————————— Energy-dependent RNA-mediated biophysically…

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Two retractions of human idiocy

Excerpt: …she was interested in the PNAS research because it identified a potential inhibitor of the hepatitis C virus… ”Definitely embarrassing:” Nobel Laureate retracts non-reproducible paper in Nature journal 1) This retraction marks the second in six months for Nature Chemistry after having none for eight years. 2) In 2009, Szostak also retracted a 2008 paper in Proceedings of the National Academy of Sciences after an outside researcher could not replicate the results. The retraction notice credited Katherine Berry, then…

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Exposing the 2nd Law to more ridicule (1)

Summary: Experiment demonstrates quantum mechanical effects from biological system Schrödinger (1944) linked the anti-entropic virucidal energy of sunlight from the physiology of pheromone-controlled reproduction in soil bacteria to all biodiversity. He then began to suspect that his colleagues, who displayed human idiocy, would kill him – if ever again he reasserted the facts. After 1944, Richard P. Feynman took a stand against the human idiocy, and lost. He was not killed, just ignored. Ignorance prevails. It always has. The virus-driven…

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Reporting new scientific truths is not allowed in the USA (2)

Summary: Genetic mutations do not drive evolution.  Energy-dependent RNA-mediated fixation of amino acid substitutions links the physiology of reproduction to biophysically constrained viral latency. With minimal effort, you can peruse the science news each day to see how many pseudoscientists report their findings outside the context of food energy-dependent pheromone-controlled biophysically constrained RNA-mediated cell type differentiation. See for example: Type 2 diabetes has hepatic origins The researchers are now working on identifying the endogenous ligand produced by the body, or…

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Energy-dependent base editing and correction of mutations (1)

Summary: Food energy-dependent base editing has been linked to biophysically constrained viral latency via microRNA editing, RNA editing and the pheromone-controlled fixation of RNA-mediated amino acid substitutions in species from microbes to humans. Correction of β-thalassemia mutant by base editor in human embryos Conclusion: Intriguingly, we found that HBB −28 (A>G) mutation repairing efficiency was about 20% in the constructed cell line and primary skin fibroblast cells. Although 10.7% of the repaired skin fibroblast cells were heterozygous, it is still…

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Light activated error-free DNA repair (3)

The vibrational theory of olfaction for the win …he and his co-authors delve into more of the specifics of olfactory receptors, including particular amino acid motifs, metal binding capacities, and disulphide bridge redox status. It turns out that amino acid side chains alone frequently pull off some rather interesting electron transfer effects without the need for fancy co-enzymes or prosthetic groups. See for an example of what one enzyme can do: See also this example of how the energy-dependent creation…

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Light-activated error free DNA repair (2)

Summary: In the diagram and diatribes that accompany claims about de novo changes in electrons and the production of nucleotides, the amount of pseudoscientific nonsense becomes perfectly clear. Pseudoscientists start with energy-dependent changes but call the changes de novo changes in electrons. That allows the pseudoscientists to dismiss any facts about how the creation of energy must be linked to the creation of enzymes. The creation of enzymes does not automagically occur and the creation of all biodiversity must occur…

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Schrodinger’s answer to Schrodinger’s question

There is no such thing as de novo control of electrons or self-assembly. Answering Schrödinger’s question: A free-energy formulation The free-energy principle (FEP) is a formal model of neuronal processes that is widely recognised in neuroscience as a unifying theory of the brain and biobehaviour. More recently, however, it has been extended beyond the brain to explain the dynamics of living systems, and their unique capacity to avoid decay. They don’t understand the question that Schrodinger answered. He linked the…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]