base editing

Pheromones protect us from viruses (4)

March 23, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
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Have you tried and repeatedly failed to put the pieces of a puzzle together? Did you claim it was impossible for anyone else to do it? To me, that exemplifies atheism. This helps to define atheism. Defining the underlying defect in insulin action in type 2 diabetes 3/17/21 …a broad signalling cascade mediated by changes in phosphorylation, gene expression and vesicular trafficking that result in increased nutrient utilisation and storage, and suppression of catabolic processes. The attempt to define the…

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Pheromones protect us from viruses (3)

March 18, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Physics, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity
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Creationists link God’s sunlight-activated generation of energy from ambient humidity and the anaerobic production of magnetite in marine microbes to electron transfer. That is how they link the ATP-dependent Creation of RNA to ammonia detection via fixation of amino acid substitutions in protein nanowires. See: Harnessing Electricity-Producing Bacteria 3/2/21 Simply put: When humans eat, their bodies convert sugars from food into electrons. These electrons transfer to oxygen to produce energy that powers the metabolic processes of the cell. It is…

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Defeating disease and Communism (4)

March 16, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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On 3/16/21, Timothy Normand Miller, in his role as the stupid atheist, @theosib2 wrote: If there were any of the typical indications of a designer in DNA, then I would consider that there must have been a designer. However, none of those can be found. Peptide synthesis at the origin of life 11/13/20 and The Amino Acid Composition of Quadruplex Binding Proteins Reveals a Shared Motif and Predicts New Potential Quadruplex Interactors 9/13/18 were linked to Properties and biological impact…

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Defeating disease and Communism (3)

March 12, 2021
James Kohl
Adaptations, Alternative Splicings, base editing, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
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More than 117,000 published works that mention ‘microRNA‘ can be linked from: Playing games with quantum interference 3/10/21 via MicroRNAs organize intrinsic variation into stem cell states 3/5/20 and MicroRNA Involvement in Signaling Pathways During Viral Infection 3/10/20 to the game for ages 14+ Genotype. Everything known to intelligent serious scientists has been linked to Thomas Hunt Morgan’s claims about chromosomal rearrangements and sympatric speciation in flies and other insects. See also: Hypoxia associated multi-omics molecular landscape of tumor tissue…

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Defeating Disease and Communism (1)

March 12, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Model Organisms, Physics, RNA Directed, RNA interference, RNA–Mediated Epigenetic Heredity, Subatomic, What's in the News
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Defeating Diseases with Energy 1/9/18 The mitochondria turn food’s hydrogen and carbon and inhaled oxygen into carbon dioxide (CO2), water and adenosine triphosphate, or ATP, which stores energy. God’s ATP-dependent Creation of RNA links protonated RNA interference to healthy longevity. See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964) The synthesis of RNA in isolated thymus nuclei is ATP dependent. For the link to RNA-mediated ecological adaptations, see:…

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Pheromones protect us from viruses (1)

March 4, 2021
James Kohl
Adaptations, base editing, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Physics, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity
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Involvement of transposable elements in neurogenesis 3/24/20 appeared in my search for indexed articles that mention microRNA on 3/4/21. There are more than 116,500 others. See: microRNA  MicroRNAs, many of which arise from transposon transcripts, also play an important role in regulating the differentiation of neuronal stem cells. That fact was established in the mid-1990s and was linked From Fertilization to Adult Sexual Behavior (1996) via pre-mRNA-mediated stem cell differentiation across kingdoms in our section on molecular epigenetics. At that time…

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Impeaching the God of Abraham (9)

March 1, 2021
James Kohl
Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Model Organisms, Physics, RNA Directed, RNA interference, RNA–Mediated Epigenetic Heredity
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In “Impeaching the God of Abraham (7) I linked achiral glycine in position 6 of the GnRH decapeptide from peptide synthesis at the origin of life to the patent for naturally occurring light-activated carbon fixation and protonated RNA interference. See also: Regulatory Mechanisms of Vitellogenesis in Insects 1/28/21 …microRNA (miRNA) and nutritional (amino acid/Target of Rapamycin and insulin) pathways interplay with JH and 20E signaling cascades to control insect vitellogenesis. This article is part of the Research Topic Germ Cell…

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Impeaching the God of Abraham (8)

February 28, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Physics, RNA Directed, RNA editing, RNA interference, Variations
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2/22/21 In Case You Missed it. The cure for HIV and all other virus-driven pathology was announced today via an indexed publication found through my daily PubMed search for microRNA. Efficacy, accumulation, and transcriptional profile of anti-HIV shRNAs expressed from human U6, 7SK, and H1 promoters 12/31/20 & indexed on 2/22/21 announced “…a functional cure for HIV.” “The RNA polymerase III promoters H1, 7SK, and U6…” were linked to the cure or the effective treatment of all virus-driven diseases via…

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Impeaching the God of Abraham (10)

February 26, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Physics, RNA Directed, RNA interference, RNA–Mediated Epigenetic Heredity
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sunlight and humidity can weaken the coronavirus — Donald J. Trump 4/23/20 …there’s no medical basis for Trump’s statements about sunlight.  Jonathan Reiner, professor of medicine at The George Washington University Hospital 4/24/20 Former president Trump was absolutely correct. He linked physics and chemistry to molecular biology and healthy longevity via Haplotype-resolved diverse human genomes and integrated analysis of structural variation 2/25/21 Structural variants (SVs) —inversions, deletions, duplications, and insertions ≥50 bp in length—and their breakpoints “…are generally more depleted…

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Impeaching the God of Abraham (7)

February 26, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, Cytosis, Diseases & Disorders, Ecology, microRNA editing, RNA Directed, RNA interference, RNA–Mediated Epigenetic Heredity
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MicroRNA biogenesis and their functions in regulating stem cell potency and differentiation 3/9/16 …summarizes the basic biogenesis and mode of actions of miRNAs, recent progress and discoveries of miRNAs in cellular reprogramming, stem cell differentiation and cellular communication, as well as miRNAs in CSCs. MicroRNAs organize intrinsic variation into stem cell states 3/5/20 was linked to prevention of  the virus-driven degradation of messenger RNA in CSCs via the fact that “…naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is…

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