base editing

Observing energy-dependent intelligence and human idiocy

November 18, 2017
James Kohl
Adaptations, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, RNA Directed, RNA editing
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Conclusion: “Absolutely no information is provided about the sensory systems that enabled predators to detect their single-celled prey. No explanation is offered of how the sensory systems came into being that permitted single-celled organisms to detect their enemies’ scents and thus survive. Neither are we told what “evolutionary” mechanisms entered the equation during the construction of this extraordinarily complex mechanism.” Seeing the Beautiful Intelligence of Microbes …slime molds have evolved a system for essentially mapping their terrain and memorizing where…

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A null mutation and healthy longevity?

November 17, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
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Summary: Food odors and pheromones biophysically constrain all pathology in species from microbes to humans. What kind of biologically uninformed science idiot leaves out everything known to serious scientists about the virus-driven degradation of messenger RNA and tells others they must falsify the neutral null theory that led to claims about a biophysically constrained beneficial “null mutation” in the Amish population of Berne, Indiana? Glutamylation Regulates Transport, Specializes Function, and Sculpts the Structure of Cilia Reported as: How to Control…

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Light-activated error free DNA repair

November 14, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
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Summary: The same set of microRNAs controls expression of the genes for rate-limiting enzymes, which control differences in the hormone production of different hormones in insects and crustaceans. That fact led to this claim in: The secret to safe DNA repair. …if you don’t have this enzyme, then this error-free repair is stopped. You can’t do it. If you can’t do the error-free repair, among other things that happen is that you expect these cells to be cancer prone. The…

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Eutrophication and phosphorylated biodiversity

November 10, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, Variations
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In Chinese philosophy, yin and yang (also yin–yang or yin yang, 陰陽 yīnyáng “dark–bright”) describe how seemingly opposite or contrary forces may actually be complementary, interconnected, and interdependent in the natural world, and how they may give rise to each other as they interrelate to one another. Last night I dreamed that someone added color to this symbol and represented it as a spinning disk (in a publication from the Nature publishing group).  The specifics of the dream helped me…

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Epigenetic facts vs variable recombination theories

November 7, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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6/14/13 Nutrient-dependent/pheromone-controlled adaptive evolution: a model ….the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to man. Minimally, this model can be compared to any other factual representations of epigenesis and epistasis for determination of the best scientific ‘fit’. 7/25/13 Jay R. Feierman: Variation is not nutrient availability and the something that is doing the selecting is not the individual…

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A mental health problem at the highest level

November 6, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, RNA-directed DNA methylation, Variations
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Investigators look for clues in deadly church shooting – news – att.net Investigators look for clues in deadly church shooting – news – att.net Todd Piro reports from Sutherland Springs, Texas. …the result of a “mental health problem at the highest level.” The mental health problem is caused by the virus-driven degradation of messenger RNA, and by the ignorance of theorists who claim that mutations cause evolution. The theorists may not be intelligent enough to play the cell biology game…

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Selfish X-linked alleles and X chromosome inactivation

November 6, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, RNA Directed, RNA editing, RNA-directed DNA methylation
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From Fertilization to Adult Sexual Behavior In our section on molecular epigenetics from 1996 we wrote: Genomic-imprinting is also manifest in specific parts of the X-inactivation region’s related XIST gene. Here male- and female-specific methyl-group patterns participate in X-inactivation in females and also in the preferential inactivation of the paternal X in human placentae of female concepti (Harrison, 1989; Monk, 1995). This process indicates that tissues of the early conceptus can sense and react differentially to epigenetic sexual dimorphisms on…

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Natural selection for racism and all pathology

November 5, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, Cytosis, Diseases & Disorders, Ecology, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA-directed DNA methylation, Variations
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Why is natural selection hard to grasp? It is not what you think…. …human cognitive tendencies interfere more with deep understanding of how natural selection works. Simply put, our intelligence and teleological reasoning interferes with the teaching of pseudoscientific nonsense. The nonsense does not place Darwin’s “conditions of life” before natural selection for reproductive fitness. Natural selection is food energy-dependent and pheromone-controlled in the context of biophysically constrained viral latency. See for comparison: The vibrational theory of olfaction for the…

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Pheromones biophysically constrain RNA-mediated biodiversity (2)

November 3, 2017
James Kohl
Adaptations, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Physics, RNA Directed, RNA editing, RNA–Mediated Epigenetic Heredity, Subatomic
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See: Combating Evolution to Fight Disease If you do not recognize the enemy, you may already be dead. See: Pheromones biophysically constrain RNA-mediated biodiversity (1) The facts are consistent with: DNA Denaturing through UV-C Photon Dissipation: A Possible Route to Archean Non-enzymatic Replication Photon dissipation is certainly the most primitive and extensive of all “metabolisms”. The results presented here also lend plausibility to the proposal of the acquisition of homochirality and information content in DNA through dissipation 7,8,17. The thermodynamic…

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Pheromones biophysically constrain RNA-mediated biodiversity (1)

November 3, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, RNA Directed, RNA editing, Variations
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Elaine Morgan on paradigm shifts. Her view of the pseudoscientific nonsense touted by neo-Darwinian theorists and “Big Bang” cosmologists is humorous and she accurately represents what’s been happening to me and others like me for the past two decades. It’s what we expect. It’s your choice to keep laughing about it. See for comparison: Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest Reported as: Scientists have identified the metabolic pathway associated with heart…

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